|
rs2292832
|
GPC1;MIR149;LOC100130449
|
Colorectal Carcinoma
|
|
0.080 |
GeneticVariation |
BEFREE |
We genotyped four common polymorphisms (i.e., rs11614913, rs3746444, rs2910164, and rs2292832) in pre-miRNAs of 353 CRC patients and 540 healthy controls to investigate the association between the SNPs and the risk of CRC using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) assay.
|
23728616 |
2013 |
|
rs2292832
|
GPC1;MIR149;LOC100130449
|
Malignant neoplasm of gastrointestinal tract
|
|
0.030 |
GeneticVariation |
BEFREE |
The present study aimed to investigate the association between two miRNA polymorphisms (miR-499 rs3746444 and miR-149 rs2292832) and gastrointestinal (GI) cancer risk.
|
24312386 |
2013 |
|
rs2292832
|
GPC1;MIR149;LOC100130449
|
Non-Small Cell Lung Carcinoma
|
|
0.020 |
GeneticVariation |
BEFREE |
These results suggest that miR-149 and miR-196a may be involved in the pathogenesis of NSCLC, and that rs2292832 and rs11614913 can be used as prognostic markers for patients with surgically resected early-stage NSCLC.
|
23470291 |
2013 |
|
rs2292832
|
GPC1;MIR149;LOC100130449
|
stage, non-small cell lung cancer
|
|
0.010 |
GeneticVariation |
BEFREE |
To test this hypothesis, we evaluated the effects of four SNPs in pre-miRNAs (pre-miR-146a rs2910164, pre-miR-149 rs2292832, pre-miR-196a rs11614913, and pre-miR-499 rs3746444) on the survival outcomes of patients with early-stage non-small-cell lung cancer (NSCLC).
|
23470291 |
2013 |
|
rs2292832
|
GPC1;MIR149;LOC100130449
|
Squamous cell carcinoma of oropharynx
|
|
0.010 |
GeneticVariation |
BEFREE |
We found that statistically significant associations with HPV16-positive SCCOP and survival were found for hsa-mir-146a rs2910164 and hsa-mir-196a2 rs11614913, while such similar associations were not observed for hsa-mir-149 rs2292832 and hsa-mir499 rs3746444.
|
23219900 |
2013 |
|
rs2292832
|
GPC1;MIR149;LOC100130449
|
Liver carcinoma
|
|
0.080 |
GeneticVariation |
BEFREE |
Association study of miR‑149 rs2292832 and miR‑608 rs4919510 and the risk of hepatocellular carcinoma in a large‑scale population.
|
25190221 |
2014 |
|
rs2292832
|
GPC1;MIR149;LOC100130449
|
Colorectal Carcinoma
|
|
0.080 |
GeneticVariation |
BEFREE |
These findings supported that the miR-196a2 rs11614913 and miR-149 rs2292832 polymorphisms may contribute to susceptibility to CRC.
|
24568449 |
2014 |
|
rs2292832
|
GPC1;MIR149;LOC100130449
|
Malignant neoplasm of breast
|
|
0.050 |
GeneticVariation |
BEFREE |
However, for the miR-146a rs2910164 (G>C), miR-149 rs2292832 (G>T), miR-373 rs12983273 (C>T), and miR-423 rs6505162 (C>A) polymorphisms, we failed to find any significant association with the risk of breast cancer in any genetic model.
|
23982873 |
2014 |
|
rs2292832
|
GPC1;MIR149;LOC100130449
|
Breast Carcinoma
|
|
0.050 |
GeneticVariation |
BEFREE |
However, for the miR-146a rs2910164 (G>C), miR-149 rs2292832 (G>T), miR-373 rs12983273 (C>T), and miR-423 rs6505162 (C>A) polymorphisms, we failed to find any significant association with the risk of breast cancer in any genetic model.
|
23982873 |
2014 |
|
rs2292832
|
GPC1;MIR149;LOC100130449
|
Stomach Carcinoma
|
|
0.040 |
GeneticVariation |
BEFREE |
The rs2910164/rs2292832/rs11614913 CTT and CCT haplotypes seems to have a protective role against GC (p = 0.002 and p = 0.001, respectively).
|
24379078 |
2014 |
|
rs2292832
|
GPC1;MIR149;LOC100130449
|
Malignant neoplasm of stomach
|
|
0.040 |
GeneticVariation |
BEFREE |
The rs2910164/rs2292832/rs11614913 CTT and CCT haplotypes seems to have a protective role against GC (p = 0.002 and p = 0.001, respectively).
|
24379078 |
2014 |
|
rs2292832
|
GPC1;MIR149;LOC100130449
|
Papillary thyroid carcinoma
|
|
0.010 |
GeneticVariation |
BEFREE |
The expression level of mature mir-149 was examined in 55 normal thyroid tissue samples; (3) RESULTS: The CC genotype of rs2292832 was significantly associated with an increased risk of PTC compared with TT homozygote (OR = 1.60, 95% CI: 1.72-2.20, p = 0.003) and TT/TC combined genotype (OR = 1.54, 95% CI: 1.14-2.09, p = 0.005).
|
25405731 |
2014 |
|
rs2292832
|
GPC1;MIR149;LOC100130449
|
Primary malignant neoplasm of lung
|
|
0.010 |
GeneticVariation |
BEFREE |
No association was observed on rs2292832 or rs3746444 polymorphism and lung cancer.
|
25077922 |
2014 |
|
rs2292832
|
GPC1;MIR149;LOC100130449
|
Carcinogenesis
|
|
0.010 |
GeneticVariation |
BEFREE |
Thus far, the role of rs2292832 in PTC tumorigenesis and progression was unclear; (2) METHOD: Rs2292832 was genotyped in 838 PTCs, 495 patients with thyroid benign tumors (BNs) and 1006 controls in a Chinese Han population.
|
25405731 |
2014 |
|
rs2292832
|
GPC1;MIR149;LOC100130449
|
Conventional (Clear Cell) Renal Cell Carcinoma
|
|
0.010 |
GeneticVariation |
BEFREE |
We genotyped four common miRNA SNPs (i.e. miR-146a rs2910164, miR-149 rs2292832, miR-196a2 rs11614913 and miR-499 rs3746444) to assess their associations with RCC risk in a two-stage case-control study (355 cases and 362 controls in discovery set, meanwhile 647 cases and 660 controls in validation set), as well as RCC survival in 311 patients.
|
24681820 |
2014 |
|
rs2292832
|
GPC1;MIR149;LOC100130449
|
Chronic kidney disease stage 5
|
|
0.010 |
GeneticVariation |
BEFREE |
Subsequently, no susceptible/protective effect was observed for rs2292832 SNP with ESRD and AR cases.
|
24978643 |
2014 |
|
rs2292832
|
GPC1;MIR149;LOC100130449
|
Carcinoma of lung
|
|
0.010 |
GeneticVariation |
BEFREE |
No association was observed on rs2292832 or rs3746444 polymorphism and lung cancer.
|
25077922 |
2014 |
|
rs2292832
|
GPC1;MIR149;LOC100130449
|
Malignant neoplasm of lung
|
|
0.010 |
GeneticVariation |
BEFREE |
No association was observed on rs2292832 or rs3746444 polymorphism and lung cancer.
|
25077922 |
2014 |
|
rs2292832
|
GPC1;MIR149;LOC100130449
|
Renal Cell Carcinoma
|
|
0.010 |
GeneticVariation |
BEFREE |
We genotyped four common miRNA SNPs (i.e. miR-146a rs2910164, miR-149 rs2292832, miR-196a2 rs11614913 and miR-499 rs3746444) to assess their associations with RCC risk in a two-stage case-control study (355 cases and 362 controls in discovery set, meanwhile 647 cases and 660 controls in validation set), as well as RCC survival in 311 patients.
|
24681820 |
2014 |
|
rs2292832
|
GPC1;MIR149;LOC100130449
|
Benign Neoplasm
|
|
0.010 |
GeneticVariation |
BEFREE |
Thus far, the role of rs2292832 in PTC tumorigenesis and progression was unclear; (2) METHOD: Rs2292832 was genotyped in 838 PTCs, 495 patients with thyroid benign tumors (BNs) and 1006 controls in a Chinese Han population.
|
25405731 |
2014 |
|
rs2292832
|
GPC1;MIR149;LOC100130449
|
Kidney Failure, Chronic
|
|
0.010 |
GeneticVariation |
BEFREE |
Subsequently, no susceptible/protective effect was observed for rs2292832 SNP with ESRD and AR cases.
|
24978643 |
2014 |
|
rs71428439
|
GPC1;MIR149;LOC100130449
|
Conventional (Clear Cell) Renal Cell Carcinoma
|
|
0.010 |
GeneticVariation |
BEFREE |
Our data suggest that the GG genotypes of miR149 rs71428439 predispose their carriers to CCRCC, and miR149 rs71428439 may be a new biomarker for predicting the risk of CCRCC.
|
25213695 |
2014 |
|
rs2292832
|
GPC1;MIR149;LOC100130449
|
Colorectal Carcinoma
|
|
0.080 |
GeneticVariation |
BEFREE |
This meta-analysis showed that rs2910164 and rs2292832 may increase the risk of CRC.
|
26078942 |
2015 |
|
rs2292832
|
GPC1;MIR149;LOC100130449
|
Liver carcinoma
|
|
0.080 |
GeneticVariation |
BEFREE |
In this research, we investigated the role of miR- 149 (rs2292832) and miR-101-1 (rs7536540) with HCC progression in Thai population.
|
26434859 |
2015 |
|
rs2292832
|
GPC1;MIR149;LOC100130449
|
Liver carcinoma
|
|
0.080 |
GeneticVariation |
BEFREE |
Predictive role of miR-146a rs2910164 (C>G), miR-149 rs2292832 (T>C), miR-196a2 rs11614913 (T>C) and miR-499 rs3746444 (T>C) in the development of hepatocellular carcinoma.
|
26823863 |
2015 |