|
rs11614913
|
HOXC6;MIR196A2
|
Non-Small Cell Lung Carcinoma
|
|
0.070 |
GeneticVariation |
BEFREE |
Therefore, the rs11614913 SNP in hsa-mir-196a2 may be a prognostic biomarker for NSCLC.
|
18521189 |
2008 |
|
rs11614913
|
HOXC6;MIR196A2
|
Malignant neoplasm of breast
|
|
0.100 |
GeneticVariation |
BEFREE |
We evaluated the associations of selected four SNPs (rs2910164, rs2292832, rs11614913, and rs3746444) in pre-miRNAs (hsa-mir-146a, hsa-mir-149, hsa-mir-196a2, and hsa-mir-499) with breast cancer risk in a case-control study of 1,009 breast cancer cases and 1,093 cancer-free controls in a population of Chinese women and we found that hsa-mir-196a2 rs11614913:T>C and hsa-mir-499 rs3746444:A>G variant genotypes were associated with significantly increased risks of breast cancer (odds ratio [OR], 1.23; 95% confidence interval [CI], 1.02-1.48 for rs11614913:T>C; and OR, 1.25; 95% CI, 1.02-1.51 for rs3746444:A>G in a dominant genetic model) in a dose-effect manner (P for trend was 0.010 and 0.037, respectively).
|
18634034 |
2009 |
|
rs11614913
|
HOXC6;MIR196A2
|
Breast Carcinoma
|
|
0.100 |
GeneticVariation |
BEFREE |
We evaluated the associations of selected four SNPs (rs2910164, rs2292832, rs11614913, and rs3746444) in pre-miRNAs (hsa-mir-146a, hsa-mir-149, hsa-mir-196a2, and hsa-mir-499) with breast cancer risk in a case-control study of 1,009 breast cancer cases and 1,093 cancer-free controls in a population of Chinese women and we found that hsa-mir-196a2 rs11614913:T>C and hsa-mir-499 rs3746444:A>G variant genotypes were associated with significantly increased risks of breast cancer (odds ratio [OR], 1.23; 95% confidence interval [CI], 1.02-1.48 for rs11614913:T>C; and OR, 1.25; 95% CI, 1.02-1.51 for rs3746444:A>G in a dominant genetic model) in a dose-effect manner (P for trend was 0.010 and 0.037, respectively).
|
18634034 |
2009 |
|
rs11614913
|
HOXC6;MIR196A2
|
Primary malignant neoplasm of lung
|
|
0.100 |
GeneticVariation |
BEFREE |
We found that miR-196a2 rs11614913 variant homozygote CC was associated with approximately 25% significantly increased risk of lung cancer compared with their wild-type homozygote TT and heterozygote TC (odds ratio, 1.25; 95% confidence interval, 1.01-1.54).
|
19293314 |
2009 |
|
rs11614913
|
HOXC6;MIR196A2
|
Malignant neoplasm of lung
|
|
0.100 |
GeneticVariation |
BEFREE |
We found that miR-196a2 rs11614913 variant homozygote CC was associated with approximately 25% significantly increased risk of lung cancer compared with their wild-type homozygote TT and heterozygote TC (odds ratio, 1.25; 95% confidence interval, 1.01-1.54).
|
19293314 |
2009 |
|
rs11614913
|
HOXC6;MIR196A2
|
Carcinoma of lung
|
|
0.100 |
GeneticVariation |
BEFREE |
We found that miR-196a2 rs11614913 variant homozygote CC was associated with approximately 25% significantly increased risk of lung cancer compared with their wild-type homozygote TT and heterozygote TC (odds ratio, 1.25; 95% confidence interval, 1.01-1.54).
|
19293314 |
2009 |
|
rs11614913
|
HOXC6;MIR196A2
|
Coronary heart disease
|
|
0.030 |
GeneticVariation |
BEFREE |
This is the first study to indicate that miR-196a2 rs11614913 plays a role in sporadic CHD susceptibility.
|
19514064 |
2009 |
|
rs11614913
|
HOXC6;MIR196A2
|
Congenital heart disease
|
|
0.010 |
GeneticVariation |
BEFREE |
Recently, we found that a genetic variant of rs11614913 in the miR-196a2 sequence could alter mature miR-196a expression and target mRNA binding; this observation led us to hypothesize that rs11614913 might influence susceptibility to sporadic congenital heart disease (CHD).
|
19514064 |
2009 |
|
rs11614913
|
HOXC6;MIR196A2
|
Malignant neoplasm of breast
|
|
0.100 |
GeneticVariation |
BEFREE |
We first performed a genetic association analysis by screening genetic variants in 15 miRNA genes and detected that a common sequence variant in hsa-miR-196a-2 (rs11614913, C-->T) was significantly associated with decreased breast cancer risk (for homozygous variant: odds ratio, 0.44; 95% confidence interval, 0.28-0.70).
|
19567675 |
2009 |
|
rs11614913
|
HOXC6;MIR196A2
|
Breast Carcinoma
|
|
0.100 |
GeneticVariation |
BEFREE |
We first performed a genetic association analysis by screening genetic variants in 15 miRNA genes and detected that a common sequence variant in hsa-miR-196a-2 (rs11614913, C-->T) was significantly associated with decreased breast cancer risk (for homozygous variant: odds ratio, 0.44; 95% confidence interval, 0.28-0.70).
|
19567675 |
2009 |
|
rs11614913
|
HOXC6;MIR196A2
|
Stomach Carcinoma
|
|
0.100 |
GeneticVariation |
BEFREE |
To evaluate the association between genetic polymorphism of miR-196a-2 (rs11614913) and risk of gastric cancer, a hospital-based case-control study was conducted in a Chinese population.
|
19834808 |
2010 |
|
rs11614913
|
HOXC6;MIR196A2
|
Malignant neoplasm of stomach
|
|
0.100 |
GeneticVariation |
BEFREE |
To evaluate the association between genetic polymorphism of miR-196a-2 (rs11614913) and risk of gastric cancer, a hospital-based case-control study was conducted in a Chinese population.
|
19834808 |
2010 |
|
rs11614913
|
HOXC6;MIR196A2
|
Breast Carcinoma
|
|
0.100 |
GeneticVariation |
BEFREE |
We compared the genotype and allele frequencies of rs2910164, rs11614913 and rs3746444 in cases versus controls of the German and Italian series, and of the two series combined; we also investigated the effect of the three SNPs on age at breast cancer diagnosis.
|
19847796 |
2010 |
|
rs11614913
|
HOXC6;MIR196A2
|
Malignant neoplasm of breast
|
|
0.100 |
GeneticVariation |
BEFREE |
In conclusion, our data suggested lack of association between SNPs rs2910164, rs11614913 and rs3746444 and breast cancer risk, or age at breast cancer onset.
|
19847796 |
2010 |
|
rs11614913
|
HOXC6;MIR196A2
|
Anthracosis
|
|
0.010 |
GeneticVariation |
BEFREE |
In a case-control study of 496 CWP patients and 513 control subjects frequency matched by exposure years and work types, we genotyped four single-nucleotide polymorphisms (SNPs) (rs2910164, rs2292832, rs11614913 and rs3746444) in pre-miRNAs (miR-146a, miR-149, miR-196a2 and miR-499) and assessed the associations with risk of CWP.
|
19881472 |
2010 |
|
rs11614913
|
HOXC6;MIR196A2
|
Liver carcinoma
|
|
0.100 |
GeneticVariation |
BEFREE |
In our study group, there was no significant association between MIR196A2 polymorphism and the risk of HBV-related HCC in all subjects, however, the risk of HCC was significantly higher with MIR196A2 rs11614913 CC genotype or C allele compared with those with the TT genotype or T allele in male patients.
|
20188135 |
2010 |
|
rs11614913
|
HOXC6;MIR196A2
|
Carcinoma of lung
|
|
0.100 |
GeneticVariation |
BEFREE |
Recent studies have implicated that the rs11614913 SNP in MIR196A2 was associated with susceptibility of lung cancer, congenital heart disease, breast cancer and shortened survival time of nonsmall cell lung cancer.
|
20188135 |
2010 |
|
rs11614913
|
HOXC6;MIR196A2
|
Malignant neoplasm of lung
|
|
0.100 |
GeneticVariation |
BEFREE |
Recent studies have implicated that the rs11614913 SNP in MIR196A2 was associated with susceptibility of lung cancer, congenital heart disease, breast cancer and shortened survival time of nonsmall cell lung cancer.
|
20188135 |
2010 |
|
rs11614913
|
HOXC6;MIR196A2
|
Primary malignant neoplasm of lung
|
|
0.100 |
GeneticVariation |
BEFREE |
Recent studies have implicated that the rs11614913 SNP in MIR196A2 was associated with susceptibility of lung cancer, congenital heart disease, breast cancer and shortened survival time of nonsmall cell lung cancer.
|
20188135 |
2010 |
|
rs11614913
|
HOXC6;MIR196A2
|
Non-Small Cell Lung Carcinoma
|
|
0.070 |
GeneticVariation |
BEFREE |
Recent studies have implicated that the rs11614913 SNP in MIR196A2 was associated with susceptibility of lung cancer, congenital heart disease, breast cancer and shortened survival time of nonsmall cell lung cancer.
|
20188135 |
2010 |
|
rs11614913
|
HOXC6;MIR196A2
|
Malignant neoplasm of lung
|
|
0.100 |
GeneticVariation |
BEFREE |
Recently, different genotypes of miR-196a polymorphisms (SNP, rs11614913) were found to be associated with the survival of patients with lung cancer and increased risk of breast cancer.
|
20229273 |
2010 |
|
rs11614913
|
HOXC6;MIR196A2
|
Breast Carcinoma
|
|
0.100 |
GeneticVariation |
BEFREE |
Recently, different genotypes of miR-196a polymorphisms (SNP, rs11614913) were found to be associated with the survival of patients with lung cancer and increased risk of breast cancer.
|
20229273 |
2010 |
|
rs11614913
|
HOXC6;MIR196A2
|
Carcinoma of lung
|
|
0.100 |
GeneticVariation |
BEFREE |
Recently, different genotypes of miR-196a polymorphisms (SNP, rs11614913) were found to be associated with the survival of patients with lung cancer and increased risk of breast cancer.
|
20229273 |
2010 |
|
rs11614913
|
HOXC6;MIR196A2
|
Primary malignant neoplasm of lung
|
|
0.100 |
GeneticVariation |
BEFREE |
Recently, different genotypes of miR-196a polymorphisms (SNP, rs11614913) were found to be associated with the survival of patients with lung cancer and increased risk of breast cancer.
|
20229273 |
2010 |
|
rs11614913
|
HOXC6;MIR196A2
|
Malignant neoplasm of breast
|
|
0.100 |
GeneticVariation |
BEFREE |
Recently, different genotypes of miR-196a polymorphisms (SNP, rs11614913) were found to be associated with the survival of patients with lung cancer and increased risk of breast cancer.
|
20229273 |
2010 |