DisGeNET - a database of gene-disease associations

HOXC6, homeobox C6, 3223

N. diseases: 80; N. variants: 14

Source: ALL

Results per page

Gene

Disease

Variant

Source

Association Type

Semantic type

Protein Class

Disease Class

Type

Original DB

Consequence

DSI _v

DPI _v

pLI

EI _vda

EL _gda

Score _vda

PMID

PMID Year

AF_EXOME

Num. PMIDs

Num. SNPs_gda

AF_GENOME

Variant

Gene

Disease

Risk Allele

Score _vda

Association Type

Original DB

Sentence supporting the association

PMID

PMID Year

dbSNP:

rs10876528

Entrez Id:	3221;3222;3223
Gene Symbol:	HOXC4;HOXC5;HOXC6

HOXC4;HOXC5;HOXC6

CUI:	C0205682
Disease:

Waist-Hip Ratio

0.700

GeneticVariation

GWASCAT

Meta-analysis of genome-wide association studies for body fat distribution in 694 649 individuals of European ancestry.

30239722

2019

dbSNP:

rs10876528

Entrez Id:	3221;3222;3223
Gene Symbol:	HOXC4;HOXC5;HOXC6

HOXC4;HOXC5;HOXC6

CUI:	C4049938
Disease:

Physical Activity Measurement

0.700

GeneticVariation

GWASCAT

Genome-wide physical activity interactions in adiposity - A meta-analysis of 200,452 adults.

28448500

2017

dbSNP:

rs12319419

Entrez Id:	3221;3222;3223
Gene Symbol:	HOXC4;HOXC5;HOXC6

HOXC4;HOXC5;HOXC6

CUI:	C0871470
Disease:

Systolic Pressure

0.700

GeneticVariation

GWASCAT

Novel genetic associations for blood pressure identified via gene-alcohol interaction in up to 570K individuals across multiple ancestries.

29912962

2018

dbSNP:

rs12319419

Entrez Id:	3221;3222;3223
Gene Symbol:	HOXC4;HOXC5;HOXC6

HOXC4;HOXC5;HOXC6

CUI:	C0001948
Disease:

Alcohol consumption

0.700

GeneticVariation

GWASCAT

Novel genetic associations for blood pressure identified via gene-alcohol interaction in up to 570K individuals across multiple ancestries.

29912962

2018

dbSNP:

rs4759319

Entrez Id:	3221;3222;3223
Gene Symbol:	HOXC4;HOXC5;HOXC6

HOXC4;HOXC5;HOXC6

CUI:	C0001948
Disease:

Alcohol consumption

0.700

GeneticVariation

GWASCAT

Novel genetic associations for blood pressure identified via gene-alcohol interaction in up to 570K individuals across multiple ancestries.

29912962

2018

dbSNP:

rs4759319

Entrez Id:	3221;3222;3223
Gene Symbol:	HOXC4;HOXC5;HOXC6

HOXC4;HOXC5;HOXC6

CUI:	C1306620
Disease:

Systolic blood pressure measurement

0.700

GeneticVariation

GWASCAT

Novel genetic associations for blood pressure identified via gene-alcohol interaction in up to 570K individuals across multiple ancestries.

29912962

2018

dbSNP:

rs4759319

Entrez Id:	3221;3222;3223
Gene Symbol:	HOXC4;HOXC5;HOXC6

HOXC4;HOXC5;HOXC6

CUI:	C0428886
Disease:

Mean blood pressure

0.700

GeneticVariation

GWASCAT

Novel genetic associations for blood pressure identified via gene-alcohol interaction in up to 570K individuals across multiple ancestries.

29912962

2018

dbSNP:

rs4759319

Entrez Id:	3221;3222;3223
Gene Symbol:	HOXC4;HOXC5;HOXC6

HOXC4;HOXC5;HOXC6

CUI:	C0871470
Disease:

Systolic Pressure

0.700

GeneticVariation

GWASCAT

Novel genetic associations for blood pressure identified via gene-alcohol interaction in up to 570K individuals across multiple ancestries.

29912962

2018

dbSNP:

rs7308105

Entrez Id:	3221;3222;3223
Gene Symbol:	HOXC4;HOXC5;HOXC6

HOXC4;HOXC5;HOXC6

CUI:	C0001948
Disease:

Alcohol consumption

0.700

GeneticVariation

GWASCAT

Novel genetic associations for blood pressure identified via gene-alcohol interaction in up to 570K individuals across multiple ancestries.

29912962

2018

dbSNP:

rs736825

Entrez Id:	3221;3222;3223
Gene Symbol:	HOXC4;HOXC5;HOXC6

HOXC4;HOXC5;HOXC6

CUI:	C0177804
Disease:

Bone Mineral Density Test

0.700

GeneticVariation

GWASDB

Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture.

22504420

2012

dbSNP:

rs736825

Entrez Id:	3221;3222;3223
Gene Symbol:	HOXC4;HOXC5;HOXC6

HOXC4;HOXC5;HOXC6

CUI:	C0005938
Disease:

Bone Density

0.700

GeneticVariation

GWASCAT

Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture.

22504420

2012

dbSNP:

rs754133

Entrez Id:	3221;3222;3223
Gene Symbol:	HOXC4;HOXC5;HOXC6

HOXC4;HOXC5;HOXC6

CUI:	C4049938
Disease:

Physical Activity Measurement

0.700

GeneticVariation

GWASCAT

Genome-wide physical activity interactions in adiposity - A meta-analysis of 200,452 adults.

28448500

2017

dbSNP:

rs754133

Entrez Id:	3221;3222;3223
Gene Symbol:	HOXC4;HOXC5;HOXC6

HOXC4;HOXC5;HOXC6

CUI:	C0037369
Disease:

Smoking

0.700

GeneticVariation

GWASCAT

Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits.

28443625

2017

dbSNP:

rs754133

Entrez Id:	3221;3222;3223
Gene Symbol:	HOXC4;HOXC5;HOXC6

HOXC4;HOXC5;HOXC6

CUI:	C1519383
Disease:

Smoking Behaviors

0.700

GeneticVariation

GWASCAT

Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits.

28443625

2017

dbSNP:

rs3803042

Entrez Id:	3223
Gene Symbol:	HOXC6

HOXC6

CUI:	C0205682
Disease:

Waist-Hip Ratio

0.700

GeneticVariation

GWASCAT

Meta-analysis of genome-wide association studies for body fat distribution in 694 649 individuals of European ancestry.

30239722

2019

dbSNP:

rs3803042

Entrez Id:	3223
Gene Symbol:	HOXC6

HOXC6

CUI:	C0023508
Disease:

White Blood Cell Count procedure

0.700

GeneticVariation

GWASCAT

Leveraging Polygenic Functional Enrichment to Improve GWAS Power.

30595370

2019

dbSNP:

rs4759316

Entrez Id:	3223
Gene Symbol:	HOXC6

HOXC6

CUI:	C0042834
Disease:

Vital capacity

0.700

GeneticVariation

GWASCAT

Leveraging Polygenic Functional Enrichment to Improve GWAS Power.

30595370

2019

dbSNP:

rs2241820

Entrez Id:	3223;3225;100874363
Gene Symbol:	HOXC6;HOXC9;HOXC-AS1

HOXC6;HOXC9;HOXC-AS1

CUI:	C0010068
Disease:

Coronary heart disease

0.010

GeneticVariation

BEFREE

We also identified four previously reported polymorphisms (rs56368105, rs12817092, rs34079606, and rs2241820) in CHD.

22106857

2012

dbSNP:

rs34079606

Entrez Id:	3223;3225;100874363
Gene Symbol:	HOXC6;HOXC9;HOXC-AS1

HOXC6;HOXC9;HOXC-AS1

CUI:	C0010068
Disease:

Coronary heart disease

0.010

GeneticVariation

BEFREE

We also identified four previously reported polymorphisms (rs56368105, rs12817092, rs34079606, and rs2241820) in CHD.

22106857

2012

dbSNP:

rs11614913

Entrez Id:	3223;406973
Gene Symbol:	HOXC6;MIR196A2

HOXC6;MIR196A2

CUI:	C4049938
Disease:

Physical Activity Measurement

0.700

GeneticVariation

GWASCAT

Genome-wide physical activity interactions in adiposity - A meta-analysis of 200,452 adults.

28448500

2017

dbSNP:

rs11614913

Entrez Id:	3223;406973
Gene Symbol:	HOXC6;MIR196A2

HOXC6;MIR196A2

CUI:	C0006142
Disease:

Malignant neoplasm of breast

0.100

GeneticVariation

BEFREE

Evaluation of single nucleotide polymorphisms in microRNAs (hsa-miR-196a2 rs11614913 C/T) from Brazilian women with breast cancer.

23228090

2012

dbSNP:

rs11614913

Entrez Id:	3223;406973
Gene Symbol:	HOXC6;MIR196A2

HOXC6;MIR196A2

CUI:	C2239176
Disease:

Liver carcinoma

0.100

GeneticVariation

BEFREE

Predictive role of miR-146a rs2910164 (C>G), miR-149 rs2292832 (T>C), miR-196a2 rs11614913 (T>C) and miR-499 rs3746444 (T>C) in the development of hepatocellular carcinoma.

26823863

2015

dbSNP:

rs11614913

Entrez Id:	3223;406973
Gene Symbol:	HOXC6;MIR196A2

HOXC6;MIR196A2

CUI:	C0678222
Disease:

Breast Carcinoma

0.100

GeneticVariation

BEFREE

We compared the genotype and allele frequencies of rs2910164, rs11614913 and rs3746444 in cases versus controls of the German and Italian series, and of the two series combined; we also investigated the effect of the three SNPs on age at breast cancer diagnosis.

19847796

2010

dbSNP:

rs11614913

Entrez Id:	3223;406973
Gene Symbol:	HOXC6;MIR196A2

HOXC6;MIR196A2

CUI:	C2239176
Disease:

Liver carcinoma

0.100

GeneticVariation

BEFREE

With respect to miR-196a2 rs11614913 polymorphism, no significant association with HCC risk was found in the overall and subgroup analyses.

25546664

2014

dbSNP:

rs11614913

Entrez Id:	3223;406973
Gene Symbol:	HOXC6;MIR196A2

HOXC6;MIR196A2

CUI:	C0024623
Disease:

Malignant neoplasm of stomach

0.100

GeneticVariation

BEFREE

In summary, the results suggested that the miR-146a rs2910164 polymorphism was related to gastric cancer risk in Asians but not in Caucasians, and no distinct correlation seemed to exist between the miR-196a-2 rs11614913 polymorphism and the risk of gastric cancer.

26345790

2015