|
rs10876528
|
HOXC4;HOXC5;HOXC6
|
Waist-Hip Ratio
|
A |
0.700 |
GeneticVariation |
GWASCAT |
Meta-analysis of genome-wide association studies for body fat distribution in 694 649 individuals of European ancestry.
|
30239722 |
2019 |
|
rs10876528
|
HOXC4;HOXC5;HOXC6
|
Physical Activity Measurement
|
A |
0.700 |
GeneticVariation |
GWASCAT |
Genome-wide physical activity interactions in adiposity - A meta-analysis of 200,452 adults.
|
28448500 |
2017 |
|
rs11614913
|
HOXC6;MIR196A2
|
Physical Activity Measurement
|
T |
0.700 |
GeneticVariation |
GWASCAT |
Genome-wide physical activity interactions in adiposity - A meta-analysis of 200,452 adults.
|
28448500 |
2017 |
|
rs11614913
|
HOXC6;MIR196A2
|
Malignant neoplasm of breast
|
|
0.100 |
GeneticVariation |
BEFREE |
Evaluation of single nucleotide polymorphisms in microRNAs (hsa-miR-196a2 rs11614913 C/T) from Brazilian women with breast cancer.
|
23228090 |
2012 |
|
rs11614913
|
HOXC6;MIR196A2
|
Liver carcinoma
|
|
0.100 |
GeneticVariation |
BEFREE |
Predictive role of miR-146a rs2910164 (C>G), miR-149 rs2292832 (T>C), miR-196a2 rs11614913 (T>C) and miR-499 rs3746444 (T>C) in the development of hepatocellular carcinoma.
|
26823863 |
2015 |
|
rs11614913
|
HOXC6;MIR196A2
|
Breast Carcinoma
|
|
0.100 |
GeneticVariation |
BEFREE |
We compared the genotype and allele frequencies of rs2910164, rs11614913 and rs3746444 in cases versus controls of the German and Italian series, and of the two series combined; we also investigated the effect of the three SNPs on age at breast cancer diagnosis.
|
19847796 |
2010 |
|
rs11614913
|
HOXC6;MIR196A2
|
Liver carcinoma
|
|
0.100 |
GeneticVariation |
BEFREE |
With respect to miR-196a2 rs11614913 polymorphism, no significant association with HCC risk was found in the overall and subgroup analyses.
|
25546664 |
2014 |
|
rs11614913
|
HOXC6;MIR196A2
|
Malignant neoplasm of stomach
|
|
0.100 |
GeneticVariation |
BEFREE |
In summary, the results suggested that the miR-146a rs2910164 polymorphism was related to gastric cancer risk in Asians but not in Caucasians, and no distinct correlation seemed to exist between the miR-196a-2 rs11614913 polymorphism and the risk of gastric cancer.
|
26345790 |
2015 |
|
rs11614913
|
HOXC6;MIR196A2
|
Primary malignant neoplasm
|
|
0.100 |
GeneticVariation |
BEFREE |
This meta-analysis suggests that the miR-196a2 rs11614913</span> polymorphism may contribute to decreased susceptibility to cancer, especially including liver cancer and lung cancer.
|
24633889 |
2014 |
|
rs11614913
|
HOXC6;MIR196A2
|
Malignant Neoplasms
|
|
0.100 |
GeneticVariation |
BEFREE |
Thus, we aimed to investigate the association of MIR196a2 rs11614913 (C/T), MIR499a rs3746444 (A/G) polymorphisms and their combination with cancer susceptibility in an Egyptian population.
|
27509977 |
2016 |
|
rs11614913
|
HOXC6;MIR196A2
|
Malignant Neoplasms
|
|
0.100 |
GeneticVariation |
BEFREE |
This meta-analysis suggests that the miR-196a2 rs11614913</span> polymorphism may contribute to decreased susceptibility to cancer, especially including liver cancer and lung cancer.
|
24633889 |
2014 |
|
rs11614913
|
HOXC6;MIR196A2
|
Liver carcinoma
|
|
0.100 |
GeneticVariation |
BEFREE |
In conclusion, the donor miR-196a-2 rs11614913 polymorphism is associated with HCC recurrence after LT and improves the predictive value of clinical models.
|
26365437 |
2016 |
|
rs11614913
|
HOXC6;MIR196A2
|
Primary malignant neoplasm of lung
|
|
0.100 |
GeneticVariation |
BEFREE |
Recent studies have implicated that the rs11614913 SNP in miR-196a2 may be associated with susceptibility to lung cancer, congenital heart disease, breast cancer, as well as reduced survival in non-small cell lung cancer.
|
21080878 |
2010 |
|
rs11614913
|
HOXC6;MIR196A2
|
Malignant Neoplasms
|
|
0.100 |
GeneticVariation |
BEFREE |
The MIR196A2 rs11614913 (T > C) polymorphism has been reported to be associated with various cancers development and progression.
|
23423813 |
2013 |
|
rs11614913
|
HOXC6;MIR196A2
|
Malignant neoplasm of lung
|
|
0.100 |
GeneticVariation |
BEFREE |
Our study confirmed that rs11614913 in hsa-miR-196a2 was associated with severe toxicity in lung cancer patients, and might help to improve individualized therapy in the future.
|
23143626 |
2012 |
|
rs11614913
|
HOXC6;MIR196A2
|
Malignant Neoplasms
|
|
0.100 |
GeneticVariation |
BEFREE |
For rs11614913, significant results were found in all the tested genetic models and T allele or its carriers were associated with decreased cancer risk in overall analysis (T vs. C: OR = 0.888, 95% CI 0.84-0.938; TT+TC vs. CC: OR = 0.897, 95% CI 0.828-0.971).
|
22952151 |
2012 |
|
rs11614913
|
HOXC6;MIR196A2
|
Primary malignant neoplasm
|
|
0.100 |
GeneticVariation |
BEFREE |
The present meta-analysis suggests an important role of mir-196a2 rs11614913 polymorphism with overall cancer risk especially in Asian population.
|
23226435 |
2012 |
|
rs11614913
|
HOXC6;MIR196A2
|
Carcinoma of lung
|
|
0.100 |
GeneticVariation |
BEFREE |
This meta-analysis suggests that the miR-196a2 rs11614913 polymorphism may contribute to decreased susceptibility to cancer, especially including liver cancer and lung cancer.
|
24633889 |
2014 |
|
rs11614913
|
HOXC6;MIR196A2
|
Primary malignant neoplasm of lung
|
|
0.100 |
GeneticVariation |
BEFREE |
However, miR-196a2 rs11614913, miR-30c-1 rs928508, miR-608 rs4919510 and miR-27a rs895819 polymorphisms were not significantly associated with lung cancer risks in any models.
|
26973201 |
2016 |
|
rs11614913
|
HOXC6;MIR196A2
|
Malignant neoplasm of breast
|
|
0.100 |
GeneticVariation |
BEFREE |
Taken together, our results indicate that the polymorphism of hsa-miR-196a2 rs11614913 is associated with cancer susceptibility, especially with breast cancer and in Chinese and Indian populations.
|
21625865 |
2012 |
|
rs11614913
|
HOXC6;MIR196A2
|
Primary malignant neoplasm of lung
|
|
0.100 |
GeneticVariation |
BEFREE |
These findings suggested that SNPs rs71428439 (miR-149), rs2910164 (miR-146a), rs928508 (mir-30c-1) and rs629367 (let-7a-2) were associated with the lung cancer prevalence, polymorphisms of rs11614913 (miR-196a-2) and rs9280508 (miR-30c-1) significantly influenced the patients' response to platinum-based chemotherapy, which may serve as potential clinical biomarkers to predict lung cancer risk and platinum-based chemotherapy response.
|
30069329 |
2018 |
|
rs11614913
|
HOXC6;MIR196A2
|
Malignant Neoplasms
|
|
0.100 |
GeneticVariation |
BEFREE |
Maturation of MIR196A2 as a gene regulator with a high potential for targeted cancer therapy can be modulated by the rs11614913 polymorphism.
|
29802998 |
2018 |
|
rs11614913
|
HOXC6;MIR196A2
|
Malignant Neoplasms
|
|
0.100 |
GeneticVariation |
BEFREE |
In this study, we genotyped five common single-nucleotide polymorphisms (SNPs) in several key miRNAs (miR-149 rs2292832, miR-146a rs2910164, miR-605 rs2043556, miR-608 rs4919510, and miR-196a2 rs11614913) and evaluated the associations between these SNPs and HNSCC risk according to cancer site with a case-control study including 576 cases and 1552 controls, which were matched by age and sex in a Chinese population.
|
27515039 |
2016 |
|
rs11614913
|
HOXC6;MIR196A2
|
Malignant Neoplasms
|
|
0.100 |
GeneticVariation |
BEFREE |
Several studies have evaluated the association between the SNP rs11614913 and cancer risk in diverse populations and in a range of cancers, with contradictory outcomes.
|
26710106 |
2016 |
|
rs11614913
|
HOXC6;MIR196A2
|
Primary malignant neoplasm
|
|
0.100 |
GeneticVariation |
BEFREE |
The results showed that miR-196a2 rs11614913 polymorphism is associated with cancer susceptibility, especially in lung cancer (homozygote comparison, OR =0.840, 95% CI =0.734-0.961; recessive model, OR =0.858, 95% CI =0.771-0.955), hepatocellular carcinoma (allelic contrast, OR =0.894, 95% CI =0.800-0.998; homozygote comparison, OR =0.900, 95% CI =0.813-0.997; recessive model, OR =0.800, 95% CI =0.678-0.944), and head and neck cancer (allelic contrast, OR =1.076, 95% CI =1.006-1.152; homozygote comparison, OR =1.214, 95% CI =1.043-1.413).
|
29535537 |
2018 |