HOXC6, homeobox C6, 3223

N. diseases: 80; N. variants: 14
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs10876528
rs10876528
Entrez Id: 3221;3222;3223
Gene Symbol: HOXC4;HOXC5;HOXC6
HOXC4;HOXC5;HOXC6
CUI: C0205682
Disease:
Waist-Hip Ratio 		A 0.700 GeneticVariation GWASCAT Meta-analysis of genome-wide association studies for body fat distribution in 694 649 individuals of European ancestry. 30239722 2019
dbSNP: rs3803042
rs3803042
Entrez Id: 3223
Gene Symbol: HOXC6
HOXC6
CUI: C0205682
Disease:
Waist-Hip Ratio 		A 0.700 GeneticVariation GWASCAT Meta-analysis of genome-wide association studies for body fat distribution in 694 649 individuals of European ancestry. 30239722 2019
dbSNP: rs3803042
rs3803042
Entrez Id: 3223
Gene Symbol: HOXC6
HOXC6
CUI: C0023508
Disease:
White Blood Cell Count procedure 		0.700 GeneticVariation GWASCAT Leveraging Polygenic Functional Enrichment to Improve GWAS Power. 30595370 2019
dbSNP: rs4759316
rs4759316
Entrez Id: 3223
Gene Symbol: HOXC6
HOXC6
CUI: C0042834
Disease:
Vital capacity 		0.700 GeneticVariation GWASCAT Leveraging Polygenic Functional Enrichment to Improve GWAS Power. 30595370 2019
dbSNP: rs12319419
rs12319419
Entrez Id: 3221;3222;3223
Gene Symbol: HOXC4;HOXC5;HOXC6
HOXC4;HOXC5;HOXC6
CUI: C0871470
Disease:
Systolic Pressure 		C 0.700 GeneticVariation GWASCAT Novel genetic associations for blood pressure identified via gene-alcohol interaction in up to 570K individuals across multiple ancestries. 29912962 2018
dbSNP: rs12319419
rs12319419
Entrez Id: 3221;3222;3223
Gene Symbol: HOXC4;HOXC5;HOXC6
HOXC4;HOXC5;HOXC6
CUI: C0001948
Disease:
Alcohol consumption 		C 0.700 GeneticVariation GWASCAT Novel genetic associations for blood pressure identified via gene-alcohol interaction in up to 570K individuals across multiple ancestries. 29912962 2018
dbSNP: rs4759319
rs4759319
Entrez Id: 3221;3222;3223
Gene Symbol: HOXC4;HOXC5;HOXC6
HOXC4;HOXC5;HOXC6
CUI: C0001948
Disease:
Alcohol consumption 		T 0.700 GeneticVariation GWASCAT Novel genetic associations for blood pressure identified via gene-alcohol interaction in up to 570K individuals across multiple ancestries. 29912962 2018
dbSNP: rs4759319
rs4759319
Entrez Id: 3221;3222;3223
Gene Symbol: HOXC4;HOXC5;HOXC6
HOXC4;HOXC5;HOXC6
CUI: C1306620
Disease:
Systolic blood pressure measurement 		T 0.700 GeneticVariation GWASCAT Novel genetic associations for blood pressure identified via gene-alcohol interaction in up to 570K individuals across multiple ancestries. 29912962 2018
dbSNP: rs4759319
rs4759319
Entrez Id: 3221;3222;3223
Gene Symbol: HOXC4;HOXC5;HOXC6
HOXC4;HOXC5;HOXC6
CUI: C0428886
Disease:
Mean blood pressure 		T 0.700 GeneticVariation GWASCAT Novel genetic associations for blood pressure identified via gene-alcohol interaction in up to 570K individuals across multiple ancestries. 29912962 2018
dbSNP: rs4759319
rs4759319
Entrez Id: 3221;3222;3223
Gene Symbol: HOXC4;HOXC5;HOXC6
HOXC4;HOXC5;HOXC6
CUI: C0871470
Disease:
Systolic Pressure 		T 0.700 GeneticVariation GWASCAT Novel genetic associations for blood pressure identified via gene-alcohol interaction in up to 570K individuals across multiple ancestries. 29912962 2018
dbSNP: rs7308105
rs7308105
Entrez Id: 3221;3222;3223
Gene Symbol: HOXC4;HOXC5;HOXC6
HOXC4;HOXC5;HOXC6
CUI: C0001948
Disease:
Alcohol consumption 		T 0.700 GeneticVariation GWASCAT Novel genetic associations for blood pressure identified via gene-alcohol interaction in up to 570K individuals across multiple ancestries. 29912962 2018
dbSNP: rs10876528
rs10876528
Entrez Id: 3221;3222;3223
Gene Symbol: HOXC4;HOXC5;HOXC6
HOXC4;HOXC5;HOXC6
CUI: C4049938
Disease:
Physical Activity Measurement 		A 0.700 GeneticVariation GWASCAT Genome-wide physical activity interactions in adiposity - A meta-analysis of 200,452 adults. 28448500 2017
dbSNP: rs11614913
rs11614913
Entrez Id: 3223;406973
Gene Symbol: HOXC6;MIR196A2
HOXC6;MIR196A2
CUI: C4049938
Disease:
Physical Activity Measurement 		T 0.700 GeneticVariation GWASCAT Genome-wide physical activity interactions in adiposity - A meta-analysis of 200,452 adults. 28448500 2017
dbSNP: rs754133
rs754133
Entrez Id: 3221;3222;3223
Gene Symbol: HOXC4;HOXC5;HOXC6
HOXC4;HOXC5;HOXC6
CUI: C4049938
Disease:
Physical Activity Measurement 		A 0.700 GeneticVariation GWASCAT Genome-wide physical activity interactions in adiposity - A meta-analysis of 200,452 adults. 28448500 2017
dbSNP: rs754133
rs754133
Entrez Id: 3221;3222;3223
Gene Symbol: HOXC4;HOXC5;HOXC6
HOXC4;HOXC5;HOXC6
CUI: C0037369
Disease:
Smoking 		A 0.700 GeneticVariation GWASCAT Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits. 28443625 2017
dbSNP: rs754133
rs754133
Entrez Id: 3221;3222;3223
Gene Symbol: HOXC4;HOXC5;HOXC6
HOXC4;HOXC5;HOXC6
CUI: C1519383
Disease:
Smoking Behaviors 		A 0.700 GeneticVariation GWASCAT Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits. 28443625 2017
dbSNP: rs736825
rs736825
Entrez Id: 3221;3222;3223
Gene Symbol: HOXC4;HOXC5;HOXC6
HOXC4;HOXC5;HOXC6
CUI: C0177804
Disease:
Bone Mineral Density Test 		C 0.700 GeneticVariation GWASDB Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture. 22504420 2012
dbSNP: rs736825
rs736825
Entrez Id: 3221;3222;3223
Gene Symbol: HOXC4;HOXC5;HOXC6
HOXC4;HOXC5;HOXC6
CUI: C0005938
Disease:
Bone Density 		C 0.700 GeneticVariation GWASCAT Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture. 22504420 2012
dbSNP: rs11614913
rs11614913
Entrez Id: 3223;406973
Gene Symbol: HOXC6;MIR196A2
HOXC6;MIR196A2
CUI: C2239176
Disease:
Liver carcinoma 		0.100 GeneticVariation BEFREE We evaluated the associations of <i>miR-499A</i>>G (rs3746444), <i>miR-149C</i>>T (rs2292832), <i>miR-196a2T</i>>C (rs11614913), and <i>miR-146aG</i>>C (rs2910164) with HCC susceptibility in 100 HCC patients (70 males and 30 females) and 120 healthy controls (70 males and 50 females), using the PCR-restriction fragment length polymorphism method. 30215231 2019
dbSNP: rs11614913
rs11614913
Entrez Id: 3223;406973
Gene Symbol: HOXC6;MIR196A2
HOXC6;MIR196A2
CUI: C0006826
Disease:
Malignant Neoplasms 		0.100 GeneticVariation BEFREE <b>Conclusions:</b> The present meta-analysis suggests that mir-196a-2 rs11614913 may contribute to the risk of cancer especially in Asians. 30930933 2019
dbSNP: rs11614913
rs11614913
Entrez Id: 3223;406973
Gene Symbol: HOXC6;MIR196A2
HOXC6;MIR196A2
CUI: C1306459
Disease:
Primary malignant neoplasm 		0.100 GeneticVariation BEFREE <b>Conclusions:</b> The present meta-analysis suggests that mir-196a-2 rs11614913 may contribute to the risk of cancer especially in Asians. 30930933 2019
dbSNP: rs11614913
rs11614913
Entrez Id: 3223;406973
Gene Symbol: HOXC6;MIR196A2
HOXC6;MIR196A2
CUI: C2239176
Disease:
Liver carcinoma 		0.100 GeneticVariation BEFREE For miR-196a2 (rs11614913) C>T polymorphisms, no significant association was found with HCC risk. 31759375 2019
dbSNP: rs11614913
rs11614913
Entrez Id: 3223;406973
Gene Symbol: HOXC6;MIR196A2
HOXC6;MIR196A2
CUI: C1306460
Disease:
Primary malignant neoplasm of lung 		0.100 GeneticVariation BEFREE These findings suggested that SNPs rs71428439 (miR-149), rs2910164 (miR-146a), rs928508 (mir-30c-1) and rs629367 (let-7a-2) were associated with the lung cancer prevalence, polymorphisms of rs11614913 (miR-196a-2) and rs9280508 (miR-30c-1) significantly influenced the patients' response to platinum-based chemotherapy, which may serve as potential clinical biomarkers to predict lung cancer risk and platinum-based chemotherapy response. 30069329 2018
dbSNP: rs11614913
rs11614913
Entrez Id: 3223;406973
Gene Symbol: HOXC6;MIR196A2
HOXC6;MIR196A2
CUI: C0006826
Disease:
Malignant Neoplasms 		0.100 GeneticVariation BEFREE Maturation of MIR196A2 as a gene regulator with a high potential for targeted cancer therapy can be modulated by the rs11614913 polymorphism. 29802998 2018
dbSNP: rs11614913
rs11614913
Entrez Id: 3223;406973
Gene Symbol: HOXC6;MIR196A2
HOXC6;MIR196A2
CUI: C1306459
Disease:
Primary malignant neoplasm 		0.100 GeneticVariation BEFREE The results showed that miR-196a2 rs11614913 polymorphism is associated with cancer susceptibility, especially in lung cancer (homozygote comparison, OR =0.840, 95% CI =0.734-0.961; recessive model, OR =0.858, 95% CI =0.771-0.955), hepatocellular carcinoma (allelic contrast, OR =0.894, 95% CI =0.800-0.998; homozygote comparison, OR =0.900, 95% CI =0.813-0.997; recessive model, OR =0.800, 95% CI =0.678-0.944), and head and neck cancer (allelic contrast, OR =1.076, 95% CI =1.006-1.152; homozygote comparison, OR =1.214, 95% CI =1.043-1.413). 29535537 2018