|
rs174547
|
FADS1;FADS2
|
Venous Thromboembolism
|
|
0.010 |
GeneticVariation |
BEFREE |
In the secondary analysis, the minor allele of rs174547 in <i>FADS1</i> was associated with significantly lower odds of any ischemic stroke, large-artery stroke, and venous thromboembolism and showed suggestive evidence of inverse association with coronary artery disease, abdominal aortic aneurysm and aortic valve stenosis.
|
31817859 |
2019 |
|
rs174547
|
FADS1;FADS2
|
Ischemic stroke
|
|
0.010 |
GeneticVariation |
BEFREE |
In the secondary analysis, the minor allele of rs174547 in <i>FADS1</i> was associated with significantly lower odds of any ischemic stroke, large-artery stroke, and venous thromboembolism and showed suggestive evidence of inverse association with coronary artery disease, abdominal aortic aneurysm and aortic valve stenosis.
|
31817859 |
2019 |
|
rs174547
|
FADS1;FADS2
|
Aortic Valve Stenosis
|
|
0.010 |
GeneticVariation |
BEFREE |
In the secondary analysis, the minor allele of rs174547 in <i>FADS1</i> was associated with significantly lower odds of any ischemic stroke, large-artery stroke, and venous thromboembolism and showed suggestive evidence of inverse association with coronary artery disease, abdominal aortic aneurysm and aortic valve stenosis.
|
31817859 |
2019 |
|
rs174547
|
FADS1;FADS2
|
Coronary Arteriosclerosis
|
|
0.010 |
GeneticVariation |
BEFREE |
In the secondary analysis, the minor allele of rs174547 in <i>FADS1</i> was associated with significantly lower odds of any ischemic stroke, large-artery stroke, and venous thromboembolism and showed suggestive evidence of inverse association with coronary artery disease, abdominal aortic aneurysm and aortic valve stenosis.
|
31817859 |
2019 |
|
rs174547
|
FADS1;FADS2
|
Cardiovascular Diseases
|
|
0.010 |
GeneticVariation |
BEFREE |
We performed a secondary analysis of the association between a functional variant (rs174547) in <i>FADS1</i>, which encodes ?5-desaturase (a key enzyme in the endogenous FA synthesis), and CVD.
|
31817859 |
2019 |
|
rs3834458
|
FADS1;FADS2
|
Non-alcoholic Fatty Liver Disease
|
|
0.010 |
GeneticVariation |
BEFREE |
Serum FADS2 concentration was positively correlated with the susceptibility of NAFLD with CAD, while the polymorphism of rs3834458 was not associated with NAFLD with CAD.
|
31781193 |
2019 |
|
rs3834458
|
FADS1;FADS2
|
Coronary Artery Disease
|
|
0.010 |
GeneticVariation |
BEFREE |
Serum FADS2 concentration was positively correlated with the susceptibility of NAFLD with CAD, while the polymorphism of rs3834458 was not associated with NAFLD with CAD.
|
31781193 |
2019 |
|
rs3834458
|
FADS1;FADS2
|
Coronary heart disease
|
|
0.010 |
GeneticVariation |
BEFREE |
Association of Nonalcoholic Fatty Liver Disease and Coronary Artery Disease with FADS2 rs3834458 Gene Polymorphism in the Chinese Han Population.
|
31781193 |
2019 |
|
rs3834458
|
FADS1;FADS2
|
Coronary Arteriosclerosis
|
|
0.010 |
GeneticVariation |
BEFREE |
Association of Nonalcoholic Fatty Liver Disease and Coronary Artery Disease with FADS2 rs3834458 Gene Polymorphism in the Chinese Han Population.
|
31781193 |
2019 |
|
rs174546
|
FADS1;FADS2
|
Stomach Carcinoma
|
|
0.010 |
GeneticVariation |
BEFREE |
In conclusion, we observed a significant inverse association between dietary DHA and the risk of gastric cancer but found that FADS1 rs174546 and FADS2 rs174583 did not modify the association between dietary n-3 or n-6 PUFAs and gastric cancer risk.
|
29491470 |
2018 |
|
rs174546
|
FADS1;FADS2
|
Malignant neoplasm of stomach
|
|
0.010 |
GeneticVariation |
BEFREE |
In conclusion, we observed a significant inverse association between dietary DHA and the risk of gastric cancer but found that FADS1 rs174546 and FADS2 rs174583 did not modify the association between dietary n-3 or n-6 PUFAs and gastric cancer risk.
|
29491470 |
2018 |
|
rs174547
|
FADS1;FADS2
|
Dyslipidemias
|
|
0.010 |
GeneticVariation |
BEFREE |
The results of this population-based study provide evidence for a relationship between lipid regulatory gene polymorphisms including GCKR (rs780094), GCKR (rs1260333), FADS (rs174547), and MLXIPL (rs3812316) with dyslipidemia in an Iranian population.
|
29858861 |
2018 |
|
rs174547
|
FADS1;FADS2
|
Major Depressive Disorder
|
|
0.010 |
GeneticVariation |
BEFREE |
Minor alleles of rs174537 and rs174547 were significantly associated with lower odds of MDD (although significance was lost after correction for multiple comparisons).
|
28552045 |
2018 |
|
rs3834458
|
FADS1;FADS2
|
Major Depressive Disorder
|
|
0.010 |
GeneticVariation |
BEFREE |
Four erythrocyte long chain (LC) fatty acids (linoleic acid [LA], α-linolenic acid [ALA], arachidonic acid [AA] and Eicosapentaenoic acid [EPA]), as well as six SNPs (rs174537, rs174547, rs174570, rs174575, rs498793 and rs3834458) within the FADS gene cluster were measured in a sample of 207 participants (154 with MDD versus 53 non-depressed controls).
|
28552045 |
2018 |
|
rs968567
|
FADS1;FADS2
|
Crohn Disease
|
|
0.010 |
GeneticVariation |
BEFREE |
These relate to SNPs associated with Crohn's disease (CD; rs102275) and rheumatoid arthritis (RA; rs968567), which affect the expression of miR-1908-5p (p<sub>rs102275</sub> = 1.44e-20, p<sub>rs968567</sub> = 2.54e-14).
|
30143393 |
2018 |
|
rs174548
|
FADS1;FADS2
|
Primary malignant neoplasm of lung
|
|
0.010 |
GeneticVariation |
BEFREE |
Taken together, we found that rs174548 was associated with both PUFAs and lung cancer.
|
28968813 |
2017 |
|
rs174548
|
FADS1;FADS2
|
Carcinoma of lung
|
|
0.010 |
GeneticVariation |
BEFREE |
Taken together, we found that rs174548 was associated with both PUFAs and lung cancer.
|
28968813 |
2017 |
|
rs174546
|
FADS1;FADS2
|
Coronary Artery Disease
|
|
0.010 |
GeneticVariation |
BEFREE |
The present study suggests that the FADS1 rs174546 SNP and the FADS2 rs174601 SNP are associated with the risk of CAD and IS, and are likely to influence serum lipid levels.
|
26261632 |
2015 |
|
rs174546
|
FADS1;FADS2
|
Cardiovascular Diseases
|
|
0.010 |
GeneticVariation |
BEFREE |
For the 11% of the population homozygous for the minor T-allele of rs174546 that associates with lower ∆5 FADS activity, high ALA intake and ALA-to-LA intake ratio may be preferable in the prevention of CVD and ischemic stroke.
|
25008580 |
2014 |
|
rs174556
|
FADS1;FADS2
|
Acute Chest Syndrome
|
|
0.010 |
GeneticVariation |
BEFREE |
The trans-phase gene-gene interaction analysis showed that the combined genotype of rs174556 (T/T) and rs3756963 (T/T) was associated with ACS (P = 0.031).
|
23555103 |
2013 |
|
rs174556
|
FADS1;FADS2
|
Hypertensive disease
|
|
0.010 |
GeneticVariation |
BEFREE |
And the results suggest that, for rs174556 C>T, the CT/TT genotypes were more likely to lead in ACS in subjects with hypertension after correction of all risk factors (OR = 4.236, 95% CI, 2.216-7.126).
|
23555103 |
2013 |
|
rs174547
|
FADS1;FADS2
|
Hyperlipidemia
|
|
0.010 |
GeneticVariation |
BEFREE |
The CC variant of rs174547 was significantly associated with hyperlipidemia compared with the TT variant (adjusted odds ratio (OR)=1.71, 95% confidence intervals (CI): 1.16-2.54).
|
22490578 |
2012 |
|
rs174556
|
FADS1;FADS2
|
Coronary Artery Disease
|
|
0.010 |
GeneticVariation |
BEFREE |
The trans phase gene-gene interaction analysis showed that the combined genotype of rs174556 (T/T) and rs3756963 (T/T) was weakly associated with the disease (P=0.043). rs174556 in the FADS1 gene is very likely to be associated with CAD in the Chinese Han population.
|
21917437 |
2011 |
|
rs174553
|
FADS1;FADS2
|
Progressive pseudorheumatoid dysplasia
|
|
0.010 |
GeneticVariation |
BEFREE |
With haplotype ACCC (major alleles) for rs174553, rs99780, rs174575, rs174583, respectively, as reference, GTCT was positively associated with PPD risk at 36 weeks' gestation, p = 0.028, and higher LA and lower ARA in plasma (p = 0.0001, p < 0.0001) and RBC ethanolamine phospholipids (p = 0.007, p = 0.005).
|
20395685 |
2009 |
|
rs174547
|
FADS1;FADS2
|
Metabolic Syndrome X
|
|
0.020 |
GeneticVariation |
BEFREE |
Korean carriers of the FADS1 rs174547 and FADS2 rs2845573 minor alleles have a greater susceptibility to MetS and moderate fat intake protected against the risk of MetS in carriers of the FADS1 major alleles.
|
29779171 |
2019 |