FADS1, fatty acid desaturase 1, 3992

N. diseases: 125; N. variants: 32
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs174547
rs174547
Entrez Id: 3992;9415
Gene Symbol: FADS1;FADS2
FADS1;FADS2
CUI: C0010068
Disease:
Coronary heart disease 		0.830 GeneticVariation BEFREE In the secondary analysis, the minor allele of rs174547 in <i>FADS1</i> was associated with significantly lower odds of any ischemic stroke, large-artery stroke, and venous thromboembolism and showed suggestive evidence of inverse association with coronary artery disease, abdominal aortic aneurysm and aortic valve stenosis. 31817859 2019
dbSNP: rs174547
rs174547
Entrez Id: 3992;9415
Gene Symbol: FADS1;FADS2
FADS1;FADS2
CUI: C0010068
Disease:
Coronary heart disease 		0.830 GeneticVariation GWASCAT Pleiotropic Meta-Analyses of Longitudinal Studies Discover Novel Genetic Variants Associated with Age-Related Diseases. 27790247 2016
dbSNP: rs174547
rs174547
Entrez Id: 3992;9415
Gene Symbol: FADS1;FADS2
FADS1;FADS2
CUI: C0010068
Disease:
Coronary heart disease 		0.830 GeneticVariation BEFREE rs174547 in FADS1 may contribute to the susceptibility of CHD by altering HDL-C and TG levels in Chinese individuals. 22490578 2012
dbSNP: rs174547
rs174547
Entrez Id: 3992;9415
Gene Symbol: FADS1;FADS2
FADS1;FADS2
CUI: C0010068
Disease:
Coronary heart disease 		0.830 GeneticVariation BEFREE The AA genotype of rs174547 was associated with increased plasma levels of C204n-6, C20:5n-3 and C22:6n-3 and increased δ-5 and δ-6 desaturase activities, but not with CHD risk. 22911844 2012
dbSNP: rs174547
rs174547
Entrez Id: 3992;9415
Gene Symbol: FADS1;FADS2
FADS1;FADS2
CUI: C0010068
Disease:
Coronary heart disease 		0.830 GeneticVariation GWASDB Genome-wide association study of coronary heart disease and its risk factors in 8,090 African Americans: the NHLBI CARe Project. 21347282 2011
dbSNP: rs968567
rs968567
Entrez Id: 3992;9415
Gene Symbol: FADS1;FADS2
FADS1;FADS2
CUI: C0003873
Disease:
Rheumatoid Arthritis 		T 0.810 GeneticVariation GWASCAT Genetic influences on susceptibility to rheumatoid arthritis in African-Americans. 30423114 2019
dbSNP: rs968567
rs968567
Entrez Id: 3992;9415
Gene Symbol: FADS1;FADS2
FADS1;FADS2
CUI: C0003873
Disease:
Rheumatoid Arthritis 		0.810 GeneticVariation BEFREE These relate to SNPs associated with Crohn's disease (CD; rs102275) and rheumatoid arthritis (RA; rs968567), which affect the expression of miR-1908-5p (p<sub>rs102275</sub> = 1.44e-20, p<sub>rs968567</sub> = 2.54e-14). 30143393 2018
dbSNP: rs968567
rs968567
Entrez Id: 3992;9415
Gene Symbol: FADS1;FADS2
FADS1;FADS2
CUI: C0003873
Disease:
Rheumatoid Arthritis 		C 0.810 GeneticVariation GWASDB Genetics of rheumatoid arthritis contributes to biology and drug discovery. 24390342 2014
dbSNP: rs968567
rs968567
Entrez Id: 3992;9415
Gene Symbol: FADS1;FADS2
FADS1;FADS2
CUI: C0003873
Disease:
Rheumatoid Arthritis 		C 0.810 GeneticVariation GWASCAT Genetics of rheumatoid arthritis contributes to biology and drug discovery. 24390342 2014
dbSNP: rs968567
rs968567
Entrez Id: 3992;9415
Gene Symbol: FADS1;FADS2
FADS1;FADS2
CUI: C0003873
Disease:
Rheumatoid Arthritis 		0.810 GeneticVariation GWASDB REL, encoding a member of the NF-kappaB family of transcription factors, is a newly defined risk locus for rheumatoid arthritis. 19503088 2009
dbSNP: rs174546
rs174546
Entrez Id: 3992;9415
Gene Symbol: FADS1;FADS2
FADS1;FADS2
CUI: C0392885
Disease:
High density lipoprotein measurement 		0.800 GeneticVariation GWASCAT Genetic analyses of diverse populations improves discovery for complex traits. 31217584 2019
dbSNP: rs174546
rs174546
Entrez Id: 3992;9415
Gene Symbol: FADS1;FADS2
FADS1;FADS2
CUI: C0202117
Disease:
Low density lipoprotein cholesterol measurement 		T 0.800 GeneticVariation GWASCAT Multi-ancestry genome-wide gene-smoking interaction study of 387,272 individuals identifies new loci associated with serum lipids. 30926973 2019
dbSNP: rs174546
rs174546
Entrez Id: 3992;9415
Gene Symbol: FADS1;FADS2
FADS1;FADS2
CUI: C0202236
Disease:
Triglycerides measurement 		0.800 GeneticVariation GWASCAT Genetic analyses of diverse populations improves discovery for complex traits. 31217584 2019
dbSNP: rs174546
rs174546
Entrez Id: 3992;9415
Gene Symbol: FADS1;FADS2
FADS1;FADS2
CUI: C0202117
Disease:
Low density lipoprotein cholesterol measurement 		0.800 GeneticVariation GWASCAT Genetic analyses of diverse populations improves discovery for complex traits. 31217584 2019
dbSNP: rs174546
rs174546
Entrez Id: 3992;9415
Gene Symbol: FADS1;FADS2
FADS1;FADS2
CUI: C0392885
Disease:
High density lipoprotein measurement 		T 0.800 GeneticVariation GWASCAT Multi-ancestry genome-wide gene-smoking interaction study of 387,272 individuals identifies new loci associated with serum lipids. 30926973 2019
dbSNP: rs174546
rs174546
Entrez Id: 3992;9415
Gene Symbol: FADS1;FADS2
FADS1;FADS2
CUI: C1445957
Disease:
Serum total cholesterol measurement 		0.800 GeneticVariation GWASCAT Genetic analyses of diverse populations improves discovery for complex traits. 31217584 2019
dbSNP: rs174546
rs174546
Entrez Id: 3992;9415
Gene Symbol: FADS1;FADS2
FADS1;FADS2
CUI: C0202236
Disease:
Triglycerides measurement 		T 0.800 GeneticVariation GWASCAT Multi-ancestry genome-wide gene-smoking interaction study of 387,272 individuals identifies new loci associated with serum lipids. 30926973 2019
dbSNP: rs174547
rs174547
Entrez Id: 3992;9415
Gene Symbol: FADS1;FADS2
FADS1;FADS2
CUI: C0202236
Disease:
Triglycerides measurement 		0.800 GeneticVariation GWASCAT Genetic analyses of diverse populations improves discovery for complex traits. 31217584 2019
dbSNP: rs174547
rs174547
Entrez Id: 3992;9415
Gene Symbol: FADS1;FADS2
FADS1;FADS2
CUI: C0392885
Disease:
High density lipoprotein measurement 		0.800 GeneticVariation GWASCAT Genetic analyses of diverse populations improves discovery for complex traits. 31217584 2019
dbSNP: rs174548
rs174548
Entrez Id: 3992;9415
Gene Symbol: FADS1;FADS2
FADS1;FADS2
CUI: C0202117
Disease:
Low density lipoprotein cholesterol measurement 		0.800 GeneticVariation GWASCAT Genetic analyses of diverse populations improves discovery for complex traits. 31217584 2019
dbSNP: rs174548
rs174548
Entrez Id: 3992;9415
Gene Symbol: FADS1;FADS2
FADS1;FADS2
CUI: C0202236
Disease:
Triglycerides measurement 		0.800 GeneticVariation GWASCAT Genetic analyses of diverse populations improves discovery for complex traits. 31217584 2019
dbSNP: rs174546
rs174546
Entrez Id: 3992;9415
Gene Symbol: FADS1;FADS2
FADS1;FADS2
CUI: C0392885
Disease:
High density lipoprotein measurement 		C 0.800 GeneticVariation GWASCAT A large electronic-health-record-based genome-wide study of serum lipids. 29507422 2018
dbSNP: rs174546
rs174546
Entrez Id: 3992;9415
Gene Symbol: FADS1;FADS2
FADS1;FADS2
CUI: C0202117
Disease:
Low density lipoprotein cholesterol measurement 		C 0.800 GeneticVariation GWASCAT A large electronic-health-record-based genome-wide study of serum lipids. 29507422 2018
dbSNP: rs174546
rs174546
Entrez Id: 3992;9415
Gene Symbol: FADS1;FADS2
FADS1;FADS2
CUI: C1445957
Disease:
Serum total cholesterol measurement 		C 0.800 GeneticVariation GWASCAT A large electronic-health-record-based genome-wide study of serum lipids. 29507422 2018
dbSNP: rs174546
rs174546
Entrez Id: 3992;9415
Gene Symbol: FADS1;FADS2
FADS1;FADS2
CUI: C0202236
Disease:
Triglycerides measurement 		C 0.800 GeneticVariation GWASCAT A large electronic-health-record-based genome-wide study of serum lipids. 29507422 2018