|
rs174547
|
FADS1;FADS2
|
Metabolic Syndrome X
|
|
0.020 |
GeneticVariation |
BEFREE |
Multiple logistic regression analyses revealed that vegetarians with TT genotype of rs174547 in <i>FADS1</i> gene had higher odds for MetS, larger WC, higher BP, and a lower level of HDL-c. Two-way ANOVA analysis showed that LA interacts with rs174547 in <i>FADS1</i> gene to affect HDL-c (<i>p</i> < 0.05) among vegetarians.
|
31340443 |
2019 |
|
rs174547
|
FADS1;FADS2
|
Coronary Artery Disease
|
|
0.020 |
GeneticVariation |
BEFREE |
In the secondary analysis, the minor allele of rs174547 in <i>FADS1</i> was associated with significantly lower odds of any ischemic stroke, large-artery stroke, and venous thromboembolism and showed suggestive evidence of inverse association with coronary artery disease, abdominal aortic aneurysm and aortic valve stenosis.
|
31817859 |
2019 |
|
rs174550
|
FADS1;FADS2
|
Gestational Diabetes
|
|
0.020 |
GeneticVariation |
BEFREE |
The results of this study indicate that the use of 8 genetic polymorphisms associated with carbohydrate and lipid metabolism and type 2 diabetes [<i>PTGS2</i> (<i>COX2</i>) rs6681231, <i>FADS1</i> rs174550, <i>HNF1B</i> rs4430796, <i>ADIPOQ</i> rs266729, <i>IL18</i> rs187238, <i>CCL2</i> rs1024611, <i>HHEX</i> rs5015480 and <i>CDKN2A/2B</i> rs10811661] together with clinical risk factors (BMI and age) may significantly improve the prediction of GDM.
|
31299695 |
2019 |
|
rs174546
|
FADS1;FADS2
|
Hypertensive disease
|
|
0.020 |
GeneticVariation |
BEFREE |
Fatty acid desaturase 1 rs174546 (C>T) did not associate with hypertension.
|
29989339 |
2018 |
|
rs174546
|
FADS1;FADS2
|
Hypertensive disease
|
|
0.020 |
GeneticVariation |
BEFREE |
The association between rs174546 (T<C) and BP z-score as well as the mediating effects of selected key PUFA levels (dihomo-gamma-linolenic acid, DGLA; arachidonic acid, ARA; eicosapentaenoic acid, EPA) or estimated D5D activity (D5D index) and BMI z-score were investigated through path model analyses, adjusting for sex, age, educational level of parents, family history of hypertension, lifestyle factors and blood levels of saturated and monounsaturated fatty acids, triglycerides and low density lipoprotein cholesterol.
|
28732058 |
2017 |
|
rs174549
|
FADS1;FADS2
|
Lip and Oral Cavity Carcinoma
|
|
0.020 |
GeneticVariation |
BEFREE |
Furthermore, a significant gene-diet multiplicative interaction was observed between FADS1 rs174549 polymorphism and fish intake for oral cancer (P=0.028).
|
28178666 |
2017 |
|
rs174549
|
FADS1;FADS2
|
Malignant neoplasm of mouth
|
|
0.020 |
GeneticVariation |
BEFREE |
A Cox proportional hazards model and Kaplan-Meier curve were used to assess the association between FADS1 rs174549 polymorphism and progression-free survival (PFS), as well as overall survival, in oral cancer.
|
27542551 |
2017 |
|
rs174549
|
FADS1;FADS2
|
Malignant neoplasm of mouth
|
|
0.020 |
GeneticVariation |
BEFREE |
Furthermore, a significant gene-diet multiplicative interaction was observed between FADS1 rs174549 polymorphism and fish intake for oral cancer (P=0.028).
|
28178666 |
2017 |
|
rs174549
|
FADS1;FADS2
|
Lip and Oral Cavity Carcinoma
|
|
0.020 |
GeneticVariation |
BEFREE |
A Cox proportional hazards model and Kaplan-Meier curve were used to assess the association between FADS1 rs174549 polymorphism and progression-free survival (PFS), as well as overall survival, in oral cancer.
|
27542551 |
2017 |
|
rs174550
|
FADS1;FADS2
|
Gestational Diabetes
|
|
0.020 |
GeneticVariation |
BEFREE |
The results of our study suggest an association between the rs174550 FADS1 polymorphism and GDM risk.
|
28359772 |
2017 |
|
rs174546
|
FADS1;FADS2
|
Ischemic stroke
|
|
0.020 |
GeneticVariation |
BEFREE |
The present study suggests that the FADS1 rs174546 SNP and the FADS2 rs174601 SNP are associated with the risk of CAD and IS, and are likely to influence serum lipid levels.
|
26261632 |
2015 |
|
rs174547
|
FADS1;FADS2
|
Coronary Artery Disease
|
|
0.020 |
GeneticVariation |
BEFREE |
Dietary n-3 LCPUFA intakes could modulate the association between FADS1 rs174547 polymorphism and CAD.
|
25849351 |
2015 |
|
rs174546
|
FADS1;FADS2
|
Ischemic stroke
|
|
0.020 |
GeneticVariation |
BEFREE |
For the 11% of the population homozygous for the minor T-allele of rs174546 that associates with lower ∆5 FADS activity, high ALA intake and ALA-to-LA intake ratio may be preferable in the prevention of CVD and ischemic stroke.
|
25008580 |
2014 |
|
rs174550
|
FADS1;FADS2
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.030 |
GeneticVariation |
BEFREE |
The results of this study indicate that the use of 8 genetic polymorphisms associated with carbohydrate and lipid metabolism and type 2 diabetes [<i>PTGS2</i> (<i>COX2</i>) rs6681231, <i>FADS1</i> rs174550, <i>HNF1B</i> rs4430796, <i>ADIPOQ</i> rs266729, <i>IL18</i> rs187238, <i>CCL2</i> rs1024611, <i>HHEX</i> rs5015480 and <i>CDKN2A/2B</i> rs10811661] together with clinical risk factors (BMI and age) may significantly improve the prediction of GDM.
|
31299695 |
2019 |
|
rs174550
|
FADS1;FADS2
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.030 |
GeneticVariation |
BEFREE |
Among single genetic variants consistently associated with diabetes-related metabolites, two (rs174550 (FADS1), rs3204953 (REV3L)) were significantly associated with type 2 diabetes in large-scale meta-analysis for type 2 diabetes.
|
28729637 |
2017 |
|
rs174550
|
FADS1;FADS2
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.030 |
GeneticVariation |
BEFREE |
We analyzed nine single-nucleotide polymorphisms (SNPs), including rs340874 (PROX1), rs4607517 (GCK), rs2191349 (DGKB-TMEM195), rs7034200 (GLIS3), rs10885122 (ADRA2A), rs174550 (FADS1), rs11605924 (CRY2), rs10830963 (MTNR1B) and rs35767 (IGF1). rs340874 (PROX1) and rs174550 (FADS1) were significantly associated with T2D (P=0.0078, OR: 1.12; and P=0.0071, OR: 1.12, respectively).
|
22992776 |
2012 |
|
rs12226877
|
FADS1;FADS2
|
Depressed bipolar I disorder
|
A |
0.700 |
GeneticVariation |
GWASCAT |
Genome-wide association study identifies 30 loci associated with bipolar disorder.
|
31043756 |
2019 |
|
rs12226877
|
FADS1;FADS2
|
Bipolar Disorder
|
A |
0.700 |
GeneticVariation |
GWASCAT |
Genome-wide association study identifies 30 loci associated with bipolar disorder.
|
31043756 |
2019 |
|
rs174544
|
FADS1;FADS2
|
Body Height
|
|
0.700 |
GeneticVariation |
GWASCAT |
Leveraging Polygenic Functional Enrichment to Improve GWAS Power.
|
30595370 |
2019 |
|
rs174546
|
FADS1;FADS2
|
QT interval feature (observable entity)
|
T |
0.700 |
GeneticVariation |
GWASCAT |
Genome-wide association meta-analysis of 30,000 samples identifies seven novel loci for quantitative ECG traits.
|
30679814 |
2019 |
|
rs174547
|
FADS1;FADS2
|
Low density lipoprotein cholesterol measurement
|
|
0.700 |
GeneticVariation |
GWASCAT |
Genetic analyses of diverse populations improves discovery for complex traits.
|
31217584 |
2019 |
|
rs174547
|
FADS1;FADS2
|
Serum total cholesterol measurement
|
|
0.700 |
GeneticVariation |
GWASCAT |
Genetic analyses of diverse populations improves discovery for complex traits.
|
31217584 |
2019 |
|
rs174548
|
FADS1;FADS2
|
Eosinophil count procedure
|
|
0.700 |
GeneticVariation |
GWASCAT |
Leveraging Polygenic Functional Enrichment to Improve GWAS Power.
|
30595370 |
2019 |
|
rs174549
|
FADS1;FADS2
|
White Blood Cell Count procedure
|
|
0.700 |
GeneticVariation |
GWASCAT |
Leveraging Polygenic Functional Enrichment to Improve GWAS Power.
|
30595370 |
2019 |
|
rs174551
|
FADS1;FADS2
|
Triglycerides measurement
|
T |
0.700 |
GeneticVariation |
GWASCAT |
Using metabolite profiling to construct and validate a metabolite risk score for predicting future weight gain.
|
31560688 |
2019 |