|
rs2569190
|
CD14;TMCO6
|
Acute myocardial infarction
|
|
0.010 |
GeneticVariation |
BEFREE |
To investigate the possible association between CD14 C(-260)T (rs2569190) gene polymorphism and the risk of acute myocardial infarction in the Egyptian population.
|
29874995 |
2018 |
|
rs2569190
|
CD14;TMCO6
|
Acute periodontitis
|
|
0.010 |
GeneticVariation |
BEFREE |
The aim of the meta-analysis was to evaluate the precise association between five widely-evaluated polymorphisms (CD14 -260C/T (rs2569190), Toll-like receptor (TLR) 2 2408G/A (rs5743708), TLR4 896A/G (rs4986790), TLR4 1196C/T (rs4986791), mannose-binding lectin (MBL) codon 54 (rs1800450)) within the PRRs and susceptibility to either chronic (CP) or aggressive periodontitis (AgP).
|
26079505 |
2015 |
|
rs2569190
|
CD14;TMCO6
|
Aggressive Periodontitis
|
|
0.010 |
GeneticVariation |
BEFREE |
The aim of the meta-analysis was to evaluate the precise association between five widely-evaluated polymorphisms (CD14 -260C/T (rs2569190), Toll-like receptor (TLR) 2 2408G/A (rs5743708), TLR4 896A/G (rs4986790), TLR4 1196C/T (rs4986791), mannose-binding lectin (MBL) codon 54 (rs1800450)) within the PRRs and susceptibility to either chronic (CP) or aggressive periodontitis (AgP).
|
26079505 |
2015 |
|
rs2569190
|
CD14;TMCO6
|
Allergic asthma
|
|
0.010 |
GeneticVariation |
BEFREE |
Individuals carrying the TT genotypes for rs2569190 were significantly associated with an increased risk of atopic asthma compared with those carrying the wild-type homozygous CC genotypes [adjusted odds ratio (OR) by gender and age, from 1.075-2.398, P = 0.025].
|
25966203 |
2015 |
|
rs2569190
|
CD14;TMCO6
|
Allergic rhinitis (disorder)
|
|
0.010 |
GeneticVariation |
BEFREE |
However, the accumulating evidence does not support an association of IL-13 SNP rs1800925 and CD14 SNP rs2569190 with AR risk.
|
29687183 |
2018 |
|
rs2569190
|
CD14;TMCO6
|
Allergic sensitization
|
|
0.010 |
GeneticVariation |
BEFREE |
A borderline significant multiplicative interaction was found between E coli and the rs2569190 (CD14/-159) SNP regarding allergic sensitization.
|
20109750 |
2010 |
|
rs2569190
|
CD14;TMCO6
|
Anemia, Sickle Cell
|
|
0.010 |
GeneticVariation |
BEFREE |
The CD14 (rs2569190) gene promoter demonstrated a significant difference (p < 0.02) between African and African American SCD groups, with the mutant variant (-159 T/T) more frequent (p < 0.0002) in African American SCD (38.9% versus 26.2%).
|
31474499 |
2019 |
|
rs2569190
|
CD14;TMCO6
|
Asthma
|
|
0.020 |
GeneticVariation |
BEFREE |
To investigate associations between total serum immunoglobulin E (IgE) levels and single nucleotide polymorphisms (SNPs) from eight candidate genes (IL-4 rs2243250, IL-4Rα rs1805010, IL-13 rs20541, IL-13Rα1 rs2495636, CD14 rs2569190, tumor necrosis factor-alpha (TNF-α) rs1800629, cytotoxic T lymphocyte-associated antigen (CTLA4) rs231775, FCER1B rs1441585) in children with asthma and to evaluate gene-gene interactions.
|
22376040 |
2012 |
|
rs2569190
|
CD14;TMCO6
|
Asthma
|
|
0.020 |
GeneticVariation |
BEFREE |
The aim of our study was to perform an association analysis of promoter single nucleotide polymorphism (SNP) -159C/T (rs2569190) in the CD14 gene for Slovenian children with asthma.
|
22015088 |
2011 |
|
rs2915863
|
CD14;TMCO6
|
Asthma
|
|
0.010 |
GeneticVariation |
BEFREE |
We observed two interactions between SNPs in CD14 and LY96 with environmental endotoxin exposure in relation to hospital admissions due to asthma exacerbation which remained significant after correction for multiple testing (CD14 SNPs rs2915863 and LY96 SNP rs17226566).
|
24902762 |
2014 |
|
rs2569190
|
CD14;TMCO6
|
Atopic disorders
|
|
0.010 |
GeneticVariation |
BEFREE |
Our results contradict previous reports that have found a protective effect of the T allele of SNP rs2569190 (C-159T) against atopic disorders.
|
15867866 |
2005 |
|
rs2569190
|
CD14;TMCO6
|
Biliary Atresia
|
|
0.010 |
GeneticVariation |
BEFREE |
We investigated the association of two cis-regulated variants in CD14 (rs2569190) and NOTCH2 (rs835576) with BA susceptibility, using the largest case-control cohort, totaling 506 BA patients and 1,473 healthy controls in a Southern Chinese population.
|
30439647 |
2018 |
|
rs5744455
|
CD14;TMCO6
|
Carcinoma of larynx
|
|
0.010 |
GeneticVariation |
BEFREE |
This study suggested that the genetic variation of CD14, rs5744455, is related to the susceptibility to laryngeal cancer, providing a theoretical basis for the study of the pathogenesis of laryngeal cancer.
|
29077168 |
2017 |
|
rs2569190
|
CD14;TMCO6
|
Cardiovascular Diseases
|
|
0.020 |
GeneticVariation |
BEFREE |
The SNP rs2569190 significantly contribute to susceptibility and development of cardiovascular disease, particularly in the East Asian population and in the subtype CHD group, in addition, a potential association was observed in the AMI group, T allele acts as a risk factor for cardiovascular disease.
|
30922395 |
2019 |
|
rs2569190
|
CD14;TMCO6
|
Cardiovascular Diseases
|
|
0.020 |
GeneticVariation |
BEFREE |
The C260T (rs2569190) single-nucleotide polymorphism (SNP) in the promoter region of the CD14 gene was implicated in CVD.
|
19433913 |
2009 |
|
rs2569190
|
CD14;TMCO6
|
Childhood asthma
|
|
0.010 |
GeneticVariation |
BEFREE |
Four SNPs, rs2569191 (-1145GA), rs5744455 (-550CT or -651CT), rs2569190 (-159CT or -260CT), and rs4914 in CD14 were genotyped in 762 children from the Environmental and Childhood Asthma study.
|
20398919 |
2010 |
|
rs2569191
|
CD14;TMCO6
|
Childhood asthma
|
|
0.010 |
GeneticVariation |
BEFREE |
Four SNPs, rs2569191 (-1145GA), rs5744455 (-550CT or -651CT), rs2569190 (-159CT or -260CT), and rs4914 in CD14 were genotyped in 762 children from the Environmental and Childhood Asthma study.
|
20398919 |
2010 |
|
rs4914
|
CD14;TMCO6
|
Childhood asthma
|
|
0.010 |
GeneticVariation |
BEFREE |
Four SNPs, rs2569191 (-1145GA), rs5744455 (-550CT or -651CT), rs2569190 (-159CT or -260CT), and rs4914 in CD14 were genotyped in 762 children from the Environmental and Childhood Asthma study.
|
20398919 |
2010 |
|
rs5744455
|
CD14;TMCO6
|
Childhood asthma
|
|
0.010 |
GeneticVariation |
BEFREE |
Four SNPs, rs2569191 (-1145GA), rs5744455 (-550CT or -651CT), rs2569190 (-159CT or -260CT), and rs4914 in CD14 were genotyped in 762 children from the Environmental and Childhood Asthma study.
|
20398919 |
2010 |
|
rs2569190
|
CD14;TMCO6
|
Chronic Periodontitis
|
|
0.010 |
GeneticVariation |
BEFREE |
The CD14 rs2569190 TT Genotype is Associated with Chronic Periodontitis.
|
28829191 |
2017 |
|
rs4914
|
CD14;TMCO6
|
Colorectal Carcinoma
|
|
0.010 |
GeneticVariation |
BEFREE |
This study highlights the LBP rs2232596 and CD14 rs4914 polymorphisms as biomarkers for elevated CRC susceptibility in the Chinese Han population.
|
21633598 |
2011 |
|
rs5744454
|
CD14;TMCO6
|
Complicated malaria
|
|
0.010 |
GeneticVariation |
BEFREE |
Our data not only reinstates that CD14 of TLR pathway plays a predominant role in P. falciparum malaria, it establishes a functional basis for genetic association of rs5744454 with P. falciparum severe malaria by demonstrating a cis-regulatory role of this promoter polymorphism.
|
30337251 |
2018 |
|
rs2569190
|
CD14;TMCO6
|
Congenital atresia of extrahepatic bile duct
|
|
0.010 |
GeneticVariation |
BEFREE |
We investigated the association of two cis-regulated variants in CD14 (rs2569190) and NOTCH2 (rs835576) with BA susceptibility, using the largest case-control cohort, totaling 506 BA patients and 1,473 healthy controls in a Southern Chinese population.
|
30439647 |
2018 |
|
rs2569190
|
CD14;TMCO6
|
Coronary Arteriosclerosis
|
|
0.010 |
GeneticVariation |
BEFREE |
Association of COL4A1 (rs605143, rs565470) and CD14 (rs2569190) genes polymorphism with coronary artery disease.
|
29299748 |
2018 |
|
rs2569190
|
CD14;TMCO6
|
Coronary Artery Disease
|
|
0.010 |
GeneticVariation |
BEFREE |
In this study, CD14 (rs2569190), CC (P = 0.008) genotypes, and C allele (P = 0.007) were found to be a positive risk factor, while TT genotype (P = 0.045) and T allele (P = 0.007) as negative risk factor for CAD.
|
29299748 |
2018 |