|
rs2569190
|
CD14;TMCO6
|
Atopic disorders
|
|
0.010 |
GeneticVariation |
BEFREE |
Our results contradict previous reports that have found a protective effect of the T allele of SNP rs2569190 (C-159T) against atopic disorders.
|
15867866 |
2005 |
|
rs2569190
|
CD14;TMCO6
|
Eczema
|
|
0.010 |
GeneticVariation |
BEFREE |
In dominant models adjusted for potential confounders, SNP rs2569193 was associated with significantly decreased risk for eczema (odds ratio [OR] for CT/TT vs CC, 0.5; 95% CI, 0.3-0.8), whereas SNP rs2569190 (also reported as the C-159T) was associated with significantly increased risk for eczema (OR for CT/TT vs CC, 2.3; 95% CI, 1.4-3.8).
|
15867866 |
2005 |
|
rs2569190
|
CD14;TMCO6
|
Cardiovascular Diseases
|
|
0.020 |
GeneticVariation |
BEFREE |
The C260T (rs2569190) single-nucleotide polymorphism (SNP) in the promoter region of the CD14 gene was implicated in CVD.
|
19433913 |
2009 |
|
rs2569190
|
CD14;TMCO6
|
Hepatitis C, Chronic
|
|
0.010 |
GeneticVariation |
BEFREE |
To analyze the correlation between CD14 rs2569190/C-159T single nucleotide polymorphism (SNP) and disease progression in chronic hepatitis C.
|
19701968 |
2009 |
|
rs2569190
|
CD14;TMCO6
|
Allergic sensitization
|
|
0.010 |
GeneticVariation |
BEFREE |
A borderline significant multiplicative interaction was found between E coli and the rs2569190 (CD14/-159) SNP regarding allergic sensitization.
|
20109750 |
2010 |
|
rs2569190
|
CD14;TMCO6
|
Childhood asthma
|
|
0.010 |
GeneticVariation |
BEFREE |
Four SNPs, rs2569191 (-1145GA), rs5744455 (-550CT or -651CT), rs2569190 (-159CT or -260CT), and rs4914 in CD14 were genotyped in 762 children from the Environmental and Childhood Asthma study.
|
20398919 |
2010 |
|
rs2569191
|
CD14;TMCO6
|
Childhood asthma
|
|
0.010 |
GeneticVariation |
BEFREE |
Four SNPs, rs2569191 (-1145GA), rs5744455 (-550CT or -651CT), rs2569190 (-159CT or -260CT), and rs4914 in CD14 were genotyped in 762 children from the Environmental and Childhood Asthma study.
|
20398919 |
2010 |
|
rs4914
|
CD14;TMCO6
|
Childhood asthma
|
|
0.010 |
GeneticVariation |
BEFREE |
Four SNPs, rs2569191 (-1145GA), rs5744455 (-550CT or -651CT), rs2569190 (-159CT or -260CT), and rs4914 in CD14 were genotyped in 762 children from the Environmental and Childhood Asthma study.
|
20398919 |
2010 |
|
rs5744455
|
CD14;TMCO6
|
Childhood asthma
|
|
0.010 |
GeneticVariation |
BEFREE |
Four SNPs, rs2569191 (-1145GA), rs5744455 (-550CT or -651CT), rs2569190 (-159CT or -260CT), and rs4914 in CD14 were genotyped in 762 children from the Environmental and Childhood Asthma study.
|
20398919 |
2010 |
|
rs2569190
|
CD14;TMCO6
|
Traveler's diarrhea
|
|
0.010 |
GeneticVariation |
BEFREE |
Two SNPs in the promoter region of CD14 (-159 C > T; rs2569190 and -4191 C > T; rs5744441) were found to be associated with TD in White visitors.
|
21596674 |
2011 |
|
rs4914
|
CD14;TMCO6
|
Colorectal Carcinoma
|
|
0.010 |
GeneticVariation |
BEFREE |
This study highlights the LBP rs2232596 and CD14 rs4914 polymorphisms as biomarkers for elevated CRC susceptibility in the Chinese Han population.
|
21633598 |
2011 |
|
rs2569190
|
CD14;TMCO6
|
Asthma
|
|
0.020 |
GeneticVariation |
BEFREE |
The aim of our study was to perform an association analysis of promoter single nucleotide polymorphism (SNP) -159C/T (rs2569190) in the CD14 gene for Slovenian children with asthma.
|
22015088 |
2011 |
|
rs2569190
|
CD14;TMCO6
|
Asthma
|
|
0.020 |
GeneticVariation |
BEFREE |
To investigate associations between total serum immunoglobulin E (IgE) levels and single nucleotide polymorphisms (SNPs) from eight candidate genes (IL-4 rs2243250, IL-4Rα rs1805010, IL-13 rs20541, IL-13Rα1 rs2495636, CD14 rs2569190, tumor necrosis factor-alpha (TNF-α) rs1800629, cytotoxic T lymphocyte-associated antigen (CTLA4) rs231775, FCER1B rs1441585) in children with asthma and to evaluate gene-gene interactions.
|
22376040 |
2012 |
|
rs2569190
|
CD14;TMCO6
|
Tuberculosis
|
|
0.010 |
GeneticVariation |
BEFREE |
In the past few years, the relationship between CD14 -159 C>T (rs2569190) polymorphism and risk of TB has been reported in various ethnic populations; however, those studies have yielded contradictory results.
|
23741383 |
2013 |
|
rs2569190
|
CD14;TMCO6
|
Crohn Disease
|
|
0.010 |
GeneticVariation |
BEFREE |
Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05).
|
24776844 |
2014 |
|
rs2569190
|
CD14;TMCO6
|
Ulcerative Colitis
|
|
0.010 |
GeneticVariation |
BEFREE |
Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05).
|
24776844 |
2014 |
|
rs2915863
|
CD14;TMCO6
|
Asthma
|
|
0.010 |
GeneticVariation |
BEFREE |
We observed two interactions between SNPs in CD14 and LY96 with environmental endotoxin exposure in relation to hospital admissions due to asthma exacerbation which remained significant after correction for multiple testing (CD14 SNPs rs2915863 and LY96 SNP rs17226566).
|
24902762 |
2014 |
|
rs2569190
|
CD14;TMCO6
|
Severe Sepsis
|
|
0.010 |
GeneticVariation |
BEFREE |
Genotypes GG of rs2569190 (the CD14 gene) and AT of rs4073 (the IL8 gene) were associated with a significantly increased risk of developing severe sepsis (p = 0.05 and p = 0.01).
|
25000179 |
2014 |
|
rs2569191
|
CD14;TMCO6
|
Wheezing
|
|
0.010 |
GeneticVariation |
BEFREE |
Of the remaining 15 SNPs, for seven we found significant relationships between genotype and endotoxin exposure in the genetic association study in relation to symptomatic airway hyper-responsiveness (CD14-rs2915863 and rs2569191, TRIF-rs4807000), current wheeze (ST-2-rs17639215, IKK-1-rs2230804, and TRIF-rs4807000), and atopy (CD14-rs2915863 and rs2569192, TRAF-6-rs5030411, and IKK-1-rs2230804).
|
25102764 |
2014 |
|
rs2915863
|
CD14;TMCO6
|
Wheezing
|
|
0.010 |
GeneticVariation |
BEFREE |
Of the remaining 15 SNPs, for seven we found significant relationships between genotype and endotoxin exposure in the genetic association study in relation to symptomatic airway hyper-responsiveness (CD14-rs2915863 and rs2569191, TRIF-rs4807000), current wheeze (ST-2-rs17639215, IKK-1-rs2230804, and TRIF-rs4807000), and atopy (CD14-rs2915863 and rs2569192, TRAF-6-rs5030411, and IKK-1-rs2230804).
|
25102764 |
2014 |
|
rs2569190
|
CD14;TMCO6
|
Septicemia
|
|
0.020 |
GeneticVariation |
BEFREE |
The single nucleotide polymorphisms (SNPs) of TLR4 (rs10759932, rs11536889, rs7873784, rs12377632, rs1927907, rs1153879) and CD14 (rs2569190 and rs2563298) in patients with sepsis and control subjects in the Guangxi Province were analyzed by using the polymerase chain reaction-single base extension (PCR-SBE) and DNA sequencing methods.
|
25394369 |
2014 |
|
rs2569190
|
CD14;TMCO6
|
Sepsis
|
|
0.020 |
GeneticVariation |
BEFREE |
The single nucleotide polymorphisms (SNPs) of TLR4 (rs10759932, rs11536889, rs7873784, rs12377632, rs1927907, rs1153879) and CD14 (rs2569190 and rs2563298) in patients with sepsis and control subjects in the Guangxi Province were analyzed by using the polymerase chain reaction-single base extension (PCR-SBE) and DNA sequencing methods.
|
25394369 |
2014 |
|
rs2563298
|
CD14;TMCO6
|
Septicemia
|
|
0.010 |
GeneticVariation |
BEFREE |
The rs11536889 polymorphism in TLR4 and rs2563298 polymorphism in CD14, and two haplotypes were associated with increased susceptibility to sepsis.
|
25394369 |
2014 |
|
rs2563298
|
CD14;TMCO6
|
Sepsis
|
|
0.010 |
GeneticVariation |
BEFREE |
The rs11536889 polymorphism in TLR4 and rs2563298 polymorphism in CD14, and two haplotypes were associated with increased susceptibility to sepsis.
|
25394369 |
2014 |
|
rs2569190
|
CD14;TMCO6
|
IgE-mediated allergic asthma
|
|
0.010 |
GeneticVariation |
BEFREE |
Individuals carrying the TT genotypes for rs2569190 were significantly associated with an increased risk of atopic asthma compared with those carrying the wild-type homozygous CC genotypes [adjusted odds ratio (OR) by gender and age, from 1.075-2.398, P = 0.025].
|
25966203 |
2015 |