|
rs2569190
|
CD14;TMCO6
|
Primary sclerosing cholangitis
|
|
0.010 |
GeneticVariation |
BEFREE |
PSC and LTx cohort patients and primary biliary cirrhosis (PBC) control patients were genotyped for the CD14 -260C>T (rs2569190) polymorphism, and genotypes were correlated with long-term clinical outcome.
|
26970220 |
2016 |
|
rs2569190
|
CD14;TMCO6
|
Posterior subcapsular cataract
|
|
0.010 |
GeneticVariation |
BEFREE |
PSC and LTx cohort patients and primary biliary cirrhosis (PBC) control patients were genotyped for the CD14 -260C>T (rs2569190) polymorphism, and genotypes were correlated with long-term clinical outcome.
|
26970220 |
2016 |
|
rs2569190
|
CD14;TMCO6
|
Allergic sensitization
|
|
0.010 |
GeneticVariation |
BEFREE |
A borderline significant multiplicative interaction was found between E coli and the rs2569190 (CD14/-159) SNP regarding allergic sensitization.
|
20109750 |
2010 |
|
rs2569190
|
CD14;TMCO6
|
Coronary Arteriosclerosis
|
|
0.010 |
GeneticVariation |
BEFREE |
Association of COL4A1 (rs605143, rs565470) and CD14 (rs2569190) genes polymorphism with coronary artery disease.
|
29299748 |
2018 |
|
rs2569190
|
CD14;TMCO6
|
Coronary heart disease
|
|
0.010 |
GeneticVariation |
BEFREE |
Association of COL4A1 (rs605143, rs565470) and CD14 (rs2569190) genes polymorphism with coronary artery disease.
|
29299748 |
2018 |
|
rs2569190
|
CD14;TMCO6
|
IgE-mediated food allergy
|
|
0.010 |
GeneticVariation |
BEFREE |
Development of FA was associated with longer periods of breastfeeding (adjusted OR = 1.792, P = .03), and this dietary pattern was more significantly related to the development of FA in infants with the homozygous TT genotype of CD14 (rs2569190) and more than 1 copy of GSTM1 and GSTT1.
|
30930272 |
2019 |
|
rs2569191
|
CD14;TMCO6
|
Childhood asthma
|
|
0.010 |
GeneticVariation |
BEFREE |
Four SNPs, rs2569191 (-1145GA), rs5744455 (-550CT or -651CT), rs2569190 (-159CT or -260CT), and rs4914 in CD14 were genotyped in 762 children from the Environmental and Childhood Asthma study.
|
20398919 |
2010 |
|
rs5744455
|
CD14;TMCO6
|
Childhood asthma
|
|
0.010 |
GeneticVariation |
BEFREE |
Four SNPs, rs2569191 (-1145GA), rs5744455 (-550CT or -651CT), rs2569190 (-159CT or -260CT), and rs4914 in CD14 were genotyped in 762 children from the Environmental and Childhood Asthma study.
|
20398919 |
2010 |
|
rs2569190
|
CD14;TMCO6
|
Childhood asthma
|
|
0.010 |
GeneticVariation |
BEFREE |
Four SNPs, rs2569191 (-1145GA), rs5744455 (-550CT or -651CT), rs2569190 (-159CT or -260CT), and rs4914 in CD14 were genotyped in 762 children from the Environmental and Childhood Asthma study.
|
20398919 |
2010 |
|
rs4914
|
CD14;TMCO6
|
Childhood asthma
|
|
0.010 |
GeneticVariation |
BEFREE |
Four SNPs, rs2569191 (-1145GA), rs5744455 (-550CT or -651CT), rs2569190 (-159CT or -260CT), and rs4914 in CD14 were genotyped in 762 children from the Environmental and Childhood Asthma study.
|
20398919 |
2010 |
|
rs2569190
|
CD14;TMCO6
|
Severe Sepsis
|
|
0.010 |
GeneticVariation |
BEFREE |
Genotypes GG of rs2569190 (the CD14 gene) and AT of rs4073 (the IL8 gene) were associated with a significantly increased risk of developing severe sepsis (p = 0.05 and p = 0.01).
|
25000179 |
2014 |
|
rs2569190
|
CD14;TMCO6
|
Allergic rhinitis (disorder)
|
|
0.010 |
GeneticVariation |
BEFREE |
However, the accumulating evidence does not support an association of IL-13 SNP rs1800925 and CD14 SNP rs2569190 with AR risk.
|
29687183 |
2018 |
|
rs2569190
|
CD14;TMCO6
|
Respiratory Tract Infections
|
|
0.010 |
GeneticVariation |
BEFREE |
In children with TT genotype at rs2569190, a higher prenatal intake of vitamins A and C, fruits, and total FV decreased RTI risk (P-trend <0.05), while in infants with TC+CC genotype, a higher prenatal intake of fruit increased RTI risk (P-trend <0.05).
|
27830580 |
2017 |
|
rs2569190
|
CD14;TMCO6
|
Septicemia
|
|
0.020 |
GeneticVariation |
BEFREE |
In conclusion, CD14 rs2569190 may act as a prognostic variable for the short-term outcome (30-day survival) in patients with sepsis.
|
26020644 |
2015 |
|
rs2569190
|
CD14;TMCO6
|
Sepsis
|
|
0.020 |
GeneticVariation |
BEFREE |
In conclusion, CD14 rs2569190 may act as a prognostic variable for the short-term outcome (30-day survival) in patients with sepsis.
|
26020644 |
2015 |
|
rs2569190
|
CD14;TMCO6
|
Eczema
|
|
0.010 |
GeneticVariation |
BEFREE |
In dominant models adjusted for potential confounders, SNP rs2569193 was associated with significantly decreased risk for eczema (odds ratio [OR] for CT/TT vs CC, 0.5; 95% CI, 0.3-0.8), whereas SNP rs2569190 (also reported as the C-159T) was associated with significantly increased risk for eczema (OR for CT/TT vs CC, 2.3; 95% CI, 1.4-3.8).
|
15867866 |
2005 |
|
rs2569190
|
CD14;TMCO6
|
Graves Disease
|
|
0.010 |
GeneticVariation |
BEFREE |
In genetic model analysis, the allele model, recessive model, and homozygous model of rs2569190 and rs2915863 embodied strong correlations with GD after the adjusting of age and gender (<i>P</i> = 0.014, <i>P</i> = 0.015, <i>P</i> = 0.009, and <i>P</i> = 0.014, <i>P</i> = 0.001, <i>P</i> = 0.006, respectively).
|
30700980 |
2018 |
|
rs2915863
|
CD14;TMCO6
|
Graves Disease
|
|
0.010 |
GeneticVariation |
BEFREE |
In genetic model analysis, the allele model, recessive model, and homozygous model of rs2569190 and rs2915863 embodied strong correlations with GD after the adjusting of age and gender (<i>P</i> = 0.014, <i>P</i> = 0.015, <i>P</i> = 0.009, and <i>P</i> = 0.014, <i>P</i> = 0.001, <i>P</i> = 0.006, respectively).
|
30700980 |
2018 |
|
rs2569190
|
CD14;TMCO6
|
Tuberculosis
|
|
0.010 |
GeneticVariation |
BEFREE |
In the past few years, the relationship between CD14 -159 C>T (rs2569190) polymorphism and risk of TB has been reported in various ethnic populations; however, those studies have yielded contradictory results.
|
23741383 |
2013 |
|
rs2569190
|
CD14;TMCO6
|
Coronary Artery Disease
|
|
0.010 |
GeneticVariation |
BEFREE |
In this study, CD14 (rs2569190), CC (P = 0.008) genotypes, and C allele (P = 0.007) were found to be a positive risk factor, while TT genotype (P = 0.045) and T allele (P = 0.007) as negative risk factor for CAD.
|
29299748 |
2018 |
|
rs2569190
|
CD14;TMCO6
|
IgE-mediated allergic asthma
|
|
0.010 |
GeneticVariation |
BEFREE |
Individuals carrying the TT genotypes for rs2569190 were significantly associated with an increased risk of atopic asthma compared with those carrying the wild-type homozygous CC genotypes [adjusted odds ratio (OR) by gender and age, from 1.075-2.398, P = 0.025].
|
25966203 |
2015 |
|
rs2569190
|
CD14;TMCO6
|
Allergic asthma
|
|
0.010 |
GeneticVariation |
BEFREE |
Individuals carrying the TT genotypes for rs2569190 were significantly associated with an increased risk of atopic asthma compared with those carrying the wild-type homozygous CC genotypes [adjusted odds ratio (OR) by gender and age, from 1.075-2.398, P = 0.025].
|
25966203 |
2015 |
|
rs2569190
|
CD14;TMCO6
|
Crohn Disease
|
|
0.010 |
GeneticVariation |
BEFREE |
Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05).
|
24776844 |
2014 |
|
rs2569190
|
CD14;TMCO6
|
Ulcerative Colitis
|
|
0.010 |
GeneticVariation |
BEFREE |
Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05).
|
24776844 |
2014 |
|
rs2569190
|
CD14;TMCO6
|
Myocardial Infarction
|
|
0.010 |
GeneticVariation |
BEFREE |
Numerous published studies have investigated the relationship between the CD14-260C>T (rs2569190) polymorphism and the risk of myocardial infarction (MI).
|
31183977 |
2019 |