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Acute Chest Syndrome
|
|
0.010 |
GeneticVariation
|
BEFREE |
To evaluate the effect of ADRB1 Arg389Gly (1165 CG), Ser49Gly (145 AG), and ADRB2 Gly16Arg (46 GA), Gln27Glu (79 CG) genotypes on survival among patients discharged with prescribed beta-blockers after an acute coronary syndrome (ACS).
|
16189366 |
2005 |
|
Acute Coronary Syndrome
|
|
0.010 |
GeneticVariation
|
BEFREE |
To evaluate the effect of ADRB1 Arg389Gly (1165 CG), Ser49Gly (145 AG), and ADRB2 Gly16Arg (46 GA), Gln27Glu (79 CG) genotypes on survival among patients discharged with prescribed beta-blockers after an acute coronary syndrome (ACS).
|
16189366 |
2005 |
|
Adenocarcinoma of lung (disorder)
|
|
0.010 |
GeneticVariation
|
BEFREE |
Aiming to test whether the genetic variants of ADRB2 modify risk of lung AC, we compared the manifestation of three common single nucleotide polymorphisms (SNPs) of ADRB2 (G-1023A, G-654A, and A46G (Gly16Arg)) between 313 patients with lung AC and 321 controls.
|
16289313 |
2006 |
|
Allergic sensitization
|
|
0.010 |
GeneticVariation
|
BEFREE |
The authors analyze the possible implication of 7 genetic polymorphisms described as asthma susceptibility genes: IL13 (C-1112T and R130Q), IL4RA (I50V, Q551R), IL5 (C-746T) and ADRB2 (Q27E and R16G) in specific olive pollen allergic sensitization.
|
18849614 |
2009 |
|
Arteriosclerosis
|
|
0.010 |
GeneticVariation
|
BEFREE |
ADRB2 Arg16Gly polymorphism, lung function, and mortality: results from the Atherosclerosis Risk in Communities study.
|
17356698 |
2007 |
|
Aspirin exacerbated respiratory disease
|
|
0.010 |
GeneticVariation
|
BEFREE |
We were the first to analyze Arg16Gly ADRB2 gene polymorphism in Japanese patients with AERD, and showed that Arg16Gly ADRB2 gene polymorphism in Japanese patients with AERD is different from that in the patients with ATA.
|
21829036 |
2011 |
|
Asthma
|
|
0.100 |
GeneticVariation
|
BEFREE |
Analysis of ADRB2 (Arg16Gly) Gene Variant with Susceptibility, Pharmacogenetic Response and Disease Severity in South Indian Asthmatics.
|
26071206 |
2015 |
|
Asthma
|
|
0.100 |
GeneticVariation
|
BEFREE |
To assess the clinical value of ADRB2 rs1042713 in children with asthma using LABA, a randomized clinical trial with well-defined outcomes is needed.
|
29992699 |
2018 |
|
Asthma
|
|
0.100 |
GeneticVariation
|
BEFREE |
These results suggest Gly16Arg genotyping in Caucasian asthma patients may have a role in the clinical management of asthma by influencing the decision of which add-on therapy to prescribe; however, larger studies are required to provide definitive conclusions regarding the clinical utility of this approach.
|
23205695 |
2013 |
|
Asthma
|
|
0.100 |
GeneticVariation
|
BEFREE |
These findings show that the risk of development of asthma or response to treatment can be, respectively, deciphered by the detection of both rs1042713 and rs1042714 variants in <i>ADRB2</i> gene.
|
30468638 |
2019 |
|
Asthma
|
|
0.100 |
GeneticVariation
|
BEFREE |
We examined the beta2-adrenergic receptor (beta2AR) polymorphisms (Arg16-->Gly, Gln27-->Glu) and clinical status for 117 asthmatics.
|
10524541 |
1999 |
|
Asthma
|
|
0.100 |
GeneticVariation
|
BEFREE |
Proposed test statistics are applied to NHANES III data to test for associations between the locus ADRB2 (rs1042713) and obesity, between VDR (rs2239185) and high blood lead level, and between TGFB1 (rs1982073) and asthma.
|
19745160 |
2010 |
|
Asthma
|
|
0.100 |
GeneticVariation
|
BEFREE |
The ADRbeta2 variations Gly(16)Arg and Gln(27)Glu and, more recently, haplotypic variations, have been the focus of numerous pharmacogenetic studies looking at responses to short-acting (SABA) and long-acting beta-agonists (LABA) in subjects with asthma.
|
18303970 |
2008 |
|
Asthma
|
|
0.100 |
GeneticVariation
|
BEFREE |
In this study we determined the relationship between the ADRB2 Arg16Gly polymorphism and GSTP1 polymorphisms, involved in bronchodilator response and oxidative stress, respectively, with susceptibility to asthma.
|
27385593 |
2016 |
|
Asthma
|
|
0.100 |
GeneticVariation
|
BEFREE |
Early studies suggest that bronchodilator reversibility and asthma worsening in patients on continuous short-acting and long-acting beta-agonists are related to the Gly16Arg genotype for the ADRB2.
|
19077707 |
2009 |
|
Asthma
|
|
0.100 |
GeneticVariation
|
BEFREE |
ADRB2 Arg16Gly showed a significant interactive effect with home dampness on being awakened at night due to wheezing and current wheezing, but no significant effect on active asthma and medication use.
|
22883364 |
2012 |
|
Asthma
|
|
0.100 |
GeneticVariation
|
BEFREE |
The primary objective was to determine the association between beta-2 adrenergic receptor (ADRB2) gene polymorphism (rs1042713, c.46A>G, p.Arg16Gly) and the response to inhaled salbutamol in North Indian children aged 5 to 15 years, with mild to moderate exacerbation of asthma.
|
27029682 |
2016 |
|
Asthma
|
|
0.100 |
GeneticVariation
|
BEFREE |
Ethnic-specific pharmacogenetic differences exist between Arg16Gly genotypes, asthma severity, and bronchodilator response in Puerto Ricans and Mexicans with asthma.
|
15557128 |
2005 |
|
Asthma
|
|
0.100 |
GeneticVariation
|
BEFREE |
Recent studies have suggested that two polymorphisms of the beta(2)-adrenergic receptor (beta(2)AR) gene at codons 16 (arginine to glycine) and 27 (glutamine to glutamate) affect an individual's airway responsiveness, or response to acute or chronic beta(2)-agonist therapy but are not risk factors for asthma.
|
11371409 |
2001 |
|
Asthma
|
|
0.100 |
GeneticVariation
|
BEFREE |
Neither the Arg16Gly nor Gln27Glu polymorphisms showed evidence of linkage to qualitative measures of asthma and bronchial hyperresponsiveness (BHR) (p > 0.10) or to quantitative measures of serum IgE and airway reactivity (p > 0.10).
|
10934093 |
2000 |
|
Asthma
|
|
0.100 |
GeneticVariation
|
BEFREE |
In the asthma group, one mutation (Arg16-->Gly) identified a subset of patients with a distinct clinical profile.(ABSTRACT TRUNCATED AT 250 WORDS)
|
8383511 |
1993 |
|
Asthma
|
|
0.100 |
GeneticVariation
|
BEFREE |
The Chinese Han children with asthma</span> had significantly higher frequencies of MS4A2 C-109T T/T (OR=1.961, P=0.001) and ADRB2 R16G A/A (OR=2.575, P=0.000) than the control group.
|
24838642 |
2014 |
|
Asthma
|
|
0.100 |
GeneticVariation
|
BEFREE |
To compare the effectiveness and safety of tiotropium vs LABAs, when used with inhaled corticosteroids (ICS) in black adults with asthma and to determine whether allelic variation at the Arg16Gly locus of the β2-adrenergic receptor (ADRB2) geneis associated with treatment response.
|
26505596 |
2015 |
|
Asthma
|
|
0.100 |
GeneticVariation
|
BEFREE |
A number of studies have investigated two common polymorphisms in the beta(2)-adrenoceptor gene, Arg/Gly16 and Gln/Glu27, in relation to asthma susceptibility.
|
15987731 |
2005 |
|
Asthma
|
|
0.100 |
GeneticVariation
|
BEFREE |
Adrenoceptor beta 2, surface gene (ADRB2) Gly16Arg genotypes have been associated with β2-agonist bronchodilator response, asthma exacerbation rate, response to methacholine, and lung function decline but not specifically in African Americans.
|
23384627 |
2013 |