|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
However, our results do not support an association between rs1042713 (Arg16Gly) polymorphisms and obesity in the populations investigated.
|
24960039 |
2014 |
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
The summary odds ratio (OR) from overall analyses showed no association between either rs1042714 or rs1042713 and obesity.
|
19186333 |
2008 |
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
There was no statistical association between A46G and hypertension risk in all subjects, Asians or Caucasians.
|
20739939 |
2010 |
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
CYP2J2 -50 G/T and ADRB2 G46A gene polymorphisms in Saudi subjects with hypertension.
|
22731644 |
2012 |
|
Asthma
|
|
0.100 |
GeneticVariation
|
BEFREE |
Analysis of ADRB2 (Arg16Gly) Gene Variant with Susceptibility, Pharmacogenetic Response and Disease Severity in South Indian Asthmatics.
|
26071206 |
2015 |
|
Asthma
|
|
0.100 |
GeneticVariation
|
BEFREE |
To assess the clinical value of ADRB2 rs1042713 in children with asthma using LABA, a randomized clinical trial with well-defined outcomes is needed.
|
29992699 |
2018 |
|
Asthma
|
|
0.100 |
GeneticVariation
|
BEFREE |
These results suggest Gly16Arg genotyping in Caucasian asthma patients may have a role in the clinical management of asthma by influencing the decision of which add-on therapy to prescribe; however, larger studies are required to provide definitive conclusions regarding the clinical utility of this approach.
|
23205695 |
2013 |
|
Asthma
|
|
0.100 |
GeneticVariation
|
BEFREE |
These findings show that the risk of development of asthma or response to treatment can be, respectively, deciphered by the detection of both rs1042713 and rs1042714 variants in <i>ADRB2</i> gene.
|
30468638 |
2019 |
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
We revealed that a combination of the Arg16Gly and Glu298Asp polymorphisms in ADRB2 and NOS3, respectively, remarkably increased the risk for hypertension in middle-aged and elderly humans.
|
19373110 |
2009 |
|
Asthma
|
|
0.100 |
GeneticVariation
|
BEFREE |
We examined the beta2-adrenergic receptor (beta2AR) polymorphisms (Arg16-->Gly, Gln27-->Glu) and clinical status for 117 asthmatics.
|
10524541 |
1999 |
|
Asthma
|
|
0.100 |
GeneticVariation
|
BEFREE |
Proposed test statistics are applied to NHANES III data to test for associations between the locus ADRB2 (rs1042713) and obesity, between VDR (rs2239185) and high blood lead level, and between TGFB1 (rs1982073) and asthma.
|
19745160 |
2010 |
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Each analysis consistently revealed the 46A allele of ADRB2 46G/A SNP and 4a allele of NOS3 4b/4a SNP to be associated with risk of hypertension.
|
25159081 |
2015 |
|
Asthma
|
|
0.100 |
GeneticVariation
|
BEFREE |
The ADRbeta2 variations Gly(16)Arg and Gln(27)Glu and, more recently, haplotypic variations, have been the focus of numerous pharmacogenetic studies looking at responses to short-acting (SABA) and long-acting beta-agonists (LABA) in subjects with asthma.
|
18303970 |
2008 |
|
Asthma
|
|
0.100 |
GeneticVariation
|
BEFREE |
In this study we determined the relationship between the ADRB2 Arg16Gly polymorphism and GSTP1 polymorphisms, involved in bronchodilator response and oxidative stress, respectively, with susceptibility to asthma.
|
27385593 |
2016 |
|
Asthma
|
|
0.100 |
GeneticVariation
|
BEFREE |
Early studies suggest that bronchodilator reversibility and asthma worsening in patients on continuous short-acting and long-acting beta-agonists are related to the Gly16Arg genotype for the ADRB2.
|
19077707 |
2009 |
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
CART analysis showed that smoking parents who overate and carried the Arg allele, ADRB2 R16G, had an odds ratio (OR) of 11.7 (95% confidence interval (CI), 2.13-64.04) for obesity compared to non-smoking parents who had none of these factors.
|
22094842 |
2011 |
|
Asthma
|
|
0.100 |
GeneticVariation
|
BEFREE |
ADRB2 Arg16Gly showed a significant interactive effect with home dampness on being awakened at night due to wheezing and current wheezing, but no significant effect on active asthma and medication use.
|
22883364 |
2012 |
|
Asthma
|
|
0.100 |
GeneticVariation
|
BEFREE |
The primary objective was to determine the association between beta-2 adrenergic receptor (ADRB2) gene polymorphism (rs1042713, c.46A>G, p.Arg16Gly) and the response to inhaled salbutamol in North Indian children aged 5 to 15 years, with mild to moderate exacerbation of asthma.
|
27029682 |
2016 |
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
Additionally, for the polymorphic sites of BAR-2 (Arg16Gly and Gln27Glu) a significant effect on obesity risk was seen.
|
12395215 |
2002 |
|
Asthma
|
|
0.100 |
GeneticVariation
|
BEFREE |
Ethnic-specific pharmacogenetic differences exist between Arg16Gly genotypes, asthma severity, and bronchodilator response in Puerto Ricans and Mexicans with asthma.
|
15557128 |
2005 |
|
Asthma
|
|
0.100 |
GeneticVariation
|
BEFREE |
Recent studies have suggested that two polymorphisms of the beta(2)-adrenergic receptor (beta(2)AR) gene at codons 16 (arginine to glycine) and 27 (glutamine to glutamate) affect an individual's airway responsiveness, or response to acute or chronic beta(2)-agonist therapy but are not risk factors for asthma.
|
11371409 |
2001 |
|
Asthma
|
|
0.100 |
GeneticVariation
|
BEFREE |
Neither the Arg16Gly nor Gln27Glu polymorphisms showed evidence of linkage to qualitative measures of asthma and bronchial hyperresponsiveness (BHR) (p > 0.10) or to quantitative measures of serum IgE and airway reactivity (p > 0.10).
|
10934093 |
2000 |
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
The aim of this study was to investigate whether polymorphisms in the beta(2)-adrenergic receptor gene (5'LC-Arg19Cys, Arg16Gly, Gln27Glu) are associated with hypertension in patients with or without type 2 diabetes and with the blood pressure levels in normotensive sib pairs.
|
11358945 |
2001 |
|
Asthma
|
|
0.100 |
GeneticVariation
|
BEFREE |
In the asthma group, one mutation (Arg16-->Gly) identified a subset of patients with a distinct clinical profile.(ABSTRACT TRUNCATED AT 250 WORDS)
|
8383511 |
1993 |
|
Asthma
|
|
0.100 |
GeneticVariation
|
BEFREE |
The Chinese Han children with asthma</span> had significantly higher frequencies of MS4A2 C-109T T/T (OR=1.961, P=0.001) and ADRB2 R16G A/A (OR=2.575, P=0.000) than the control group.
|
24838642 |
2014 |