|
Asthma
|
|
0.100 |
GeneticVariation
|
BEFREE |
In the asthma group, one mutation (Arg16-->Gly) identified a subset of patients with a distinct clinical profile.(ABSTRACT TRUNCATED AT 250 WORDS)
|
8383511 |
1993 |
|
Asthma
|
|
0.100 |
GeneticVariation
|
BEFREE |
Polymorphisms at amino acid positions 16 (arginine to glycine) and 27 (glutamine to glutamic acid) of the beta2-adrenoreceptor (B2AR) gene are known to be functionally relevant and have been associated with more severe forms of asthma, nocturnal asthma and decreased airway responsiveness in asthmatic subjects.
|
10469027 |
1999 |
|
Asthma
|
|
0.100 |
GeneticVariation
|
BEFREE |
We examined the beta2-adrenergic receptor (beta2AR) polymorphisms (Arg16-->Gly, Gln27-->Glu) and clinical status for 117 asthmatics.
|
10524541 |
1999 |
|
Asthma
|
|
0.100 |
GeneticVariation
|
BEFREE |
Neither the Arg16Gly nor Gln27Glu polymorphisms showed evidence of linkage to qualitative measures of asthma and bronchial hyperresponsiveness (BHR) (p > 0.10) or to quantitative measures of serum IgE and airway reactivity (p > 0.10).
|
10934093 |
2000 |
|
Bronchial Hyperreactivity
|
|
0.010 |
GeneticVariation
|
BEFREE |
Neither the Arg16Gly nor Gln27Glu polymorphisms showed evidence of linkage to qualitative measures of asthma and bronchial hyperresponsiveness (BHR) (p > 0.10) or to quantitative measures of serum IgE and airway reactivity (p > 0.10).
|
10934093 |
2000 |
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
The Arg16Gly genotype showed significant relationships to elevated central distribution of body fat and to systolic blood pressure, whilst the Glu27Glu genotype was associated with elevated leptin and triglyceride levels but not to other measurements, including obesity variables.
|
10971791 |
2000 |
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our results suggest that the Gln27Glu and Arg16Gly polymorphisms of the beta2AR gene are not a major contributing factor to obesity in Japanese men.
|
11016907 |
2000 |
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
In particular, Arg16Gly was shown to be associated with hypertension in black and white subjects.
|
11230287 |
2001 |
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
The aim of this study was to investigate whether polymorphisms in the beta(2)-adrenergic receptor gene (5'LC-Arg19Cys, Arg16Gly, Gln27Glu) are associated with hypertension in patients with or without type 2 diabetes and with the blood pressure levels in normotensive sib pairs.
|
11358945 |
2001 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.030 |
GeneticVariation
|
BEFREE |
The aim of this study was to investigate whether polymorphisms in the beta(2)-adrenergic receptor gene (5'LC-Arg19Cys, Arg16Gly, Gln27Glu) are associated with hypertension in patients with or without type 2 diabetes and with the blood pressure levels in normotensive sib pairs.
|
11358945 |
2001 |
|
Asthma
|
|
0.100 |
GeneticVariation
|
BEFREE |
Recent studies have suggested that two polymorphisms of the beta(2)-adrenergic receptor (beta(2)AR) gene at codons 16 (arginine to glycine) and 27 (glutamine to glutamate) affect an individual's airway responsiveness, or response to acute or chronic beta(2)-agonist therapy but are not risk factors for asthma.
|
11371409 |
2001 |
|
Stress, Psychological
|
|
0.020 |
GeneticVariation
|
BEFREE |
Subjects who were homozygous both GG in the G-261A polymorphism at the alpha(2A)AR locus and GlyGly in the Arg16Gly polymorphism at the beta2-adrenergic (beta2AR) receptor loci had significantly higher insulin sensitivity and lower catecholamine levels during mental stress than subjects with other genotypes.
|
11467765 |
2001 |
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
The Gly16Arg was significantly associated with hypertension (P < .03).
|
11775126 |
2001 |
|
Glaucoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
Post-exercise, reductions in mean IOP values were found in 16 subjects with the Gly16Gly and Arg16Gly genotypes, but these values remained low in the eight patients with the Gly16Gly genotype 3 h post-exercise, whereas they returned to baseline within 1 h in the eight subjects with the Arg16Gly genotype. beta 2AR stimulation during exercise could be an important regulator of IOP response and determining beta 2AR polymorphisms may improve understanding of pathogenesis and treatment selection in ophthalmic diseases, e.g. glaucoma.
|
11921496 |
2002 |
|
Intraocular pressure disorder
|
|
0.010 |
GeneticVariation
|
BEFREE |
Post-exercise, reductions in mean IOP values were found in 16 subjects with the Gly16Gly and Arg16Gly genotypes, but these values remained low in the eight patients with the Gly16Gly genotype 3 h post-exercise, whereas they returned to baseline within 1 h in the eight subjects with the Arg16Gly genotype. beta 2AR stimulation during exercise could be an important regulator of IOP response and determining beta 2AR polymorphisms may improve understanding of pathogenesis and treatment selection in ophthalmic diseases, e.g. glaucoma.
|
11921496 |
2002 |
|
Essential Hypertension
|
|
0.050 |
GeneticVariation
|
BEFREE |
Since beta2-adrenergic receptors (beta2AR) can influence blood pressure not only by vasodilation, but also participate in noradrenaline release from sympathetic nerve endings, we have studied whether Arg16Gly polymorphism of the beta2AR gene is associated with predisposition to essential hypertension and increased plasma noradrenaline concentration in offspring from normotensive (SN) and hypertensive parents (SH).
|
12361188 |
2002 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.030 |
GeneticVariation
|
BEFREE |
The Arg16Gly polymorphism was independently associated with age of onset in type 2 diabetes (P = 0.017).
|
12390345 |
2002 |
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
Additionally, for the polymorphic sites of BAR-2 (Arg16Gly and Gln27Glu) a significant effect on obesity risk was seen.
|
12395215 |
2002 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.030 |
GeneticVariation
|
BEFREE |
The purpose of the present study was to evaluate the influence of the Arg16Gly variant allele of B2AR on insulin secretion in patients with type 2 diabetes.
|
14693408 |
2004 |
|
Asthma
|
|
0.100 |
GeneticVariation
|
BEFREE |
The Arg16Gly polymorphism may be important to the association between increased AR in infancy and reduced lung function in childhood and may also be a determinant of asthma severity in children but not asthma per se.
|
15248848 |
2004 |
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
Several case-control studies have explored the possible association between polymorphism in the beta2 adrenoreceptor gene (beta2AR), hypertension, and obesity--the focus being in particular on the Arg16Gly and Gln27Glu substitutions, which appear to modify the extracellular part of the beta2AR with possible functional modification.
|
15323067 |
2004 |
|
Essential Hypertension
|
|
0.050 |
GeneticVariation
|
BEFREE |
Beta2 adrenergic receptor gene Arg16Gly polymorphism is associated with therapeutic efficacy of benazepril on essential hypertension in Chinese.
|
15554460 |
2004 |
|
Asthma
|
|
0.100 |
GeneticVariation
|
BEFREE |
Ethnic-specific pharmacogenetic differences exist between Arg16Gly genotypes, asthma severity, and bronchodilator response in Puerto Ricans and Mexicans with asthma.
|
15557128 |
2005 |
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Common Arg16Gly and Gln27Glu polymorphisms of the beta(2)-adrenergic receptor (beta(2)AR) have been associated with hypertension and coronary disease.
|
15797659 |
2005 |
|
Coronary Artery Disease
|
|
0.030 |
GeneticVariation
|
BEFREE |
Common Arg16Gly and Gln27Glu polymorphisms of the beta(2)-adrenergic receptor (beta(2)AR) have been associated with hypertension and coronary disease.
|
15797659 |
2005 |