|
Temporomandibular Joint Disorders
|
|
0.010 |
GeneticVariation
|
BEFREE |
With respect to the ADRB2 gene, the non-polymorphic AA genotype in the rs1042713 region was more prevalent in the articular TMD group than in the muscular TMD group (P= 0.05).
|
31285095 |
2020 |
|
COPD exacerbation
|
|
0.010 |
GeneticVariation
|
BEFREE |
In current users of β<sub>2</sub>-agonists, the risk of COPD exacerbation decreased by 30% (hazard ratio (HR); 0.70, 95% CI: 0.59-0.84) for each copy of the Arg allele of rs1042713 and by 20% (HR; 0.80, 95% CI: 0.69-0.94) for each copy of the Gln allele of rs1042714.
|
31683975 |
2019 |
|
Pulmonary Emphysema
|
|
0.010 |
GeneticVariation
|
BEFREE |
Combination analysis of ADRB2 Arg16Gly polymorphism and EHI% may predict the effectiveness of β<sub>2</sub>-adrenergic receptor agonist treatment in patients with COPD and emphysema.
|
28964817 |
2018 |
|
Chronic heart failure
|
|
0.010 |
GeneticVariation
|
BEFREE |
This Arg16Gly genotype-dependent heterogeneity in clinical outcomes of HF was successfully validated in the second independent population.
|
30374408 |
2018 |
|
Gastroschisis
|
|
0.010 |
GeneticVariation
|
BEFREE |
The rs4961 (ADD1), rs5443 (GNB3), rs1042713, and rs1042714 (ADRB2) were significantly associated with gastroschisis.
|
29550988 |
2018 |
|
Locally advanced breast cancer
|
|
0.010 |
GeneticVariation
|
BEFREE |
rs1042713, which is located in the <i>ADRB2</i> gene, could predict pCR to taxane-and platinum-based neoadjuvant chemotherapy in LABC.
|
30568487 |
2018 |
|
Tuberculosis, Pulmonary
|
|
0.010 |
GeneticVariation
|
BEFREE |
Genotype distributions of the rs1042713 (Arg16Gly +46A>G) and rs1042714 (Gln27Glu +79C>G) polymorphisms in ADRB2 gene in 106 patients with pulmonary tuberculosis and 88 healthy subjects were studied by PCR-RFLP method in an Iranian population.
|
27900465 |
2017 |
|
Hypertriglyceridemia
|
|
0.010 |
GeneticVariation
|
BEFREE |
Subsequently, in the case-control study, we observed that the A46G polymorphism was significantly associated with the elevated risk of hypertriglyceridemia in the dominant model (OR: 1.47, 95%CI: 1.05-2.06, P = 0.025).
|
28287890 |
2017 |
|
Tuberculosis
|
|
0.010 |
GeneticVariation
|
BEFREE |
The association was reported between rs1042713 and rs1042714 polymorphisms in ADRB2 gene and tuberculosis for the first time. rs1042713*G and rs1042714*G polymorphisms in ADRB2 gene makes people more susceptible to develop the disease.
|
27900465 |
2017 |
|
Atopic IgE-mediated allergic disorder
|
|
0.010 |
GeneticVariation
|
BEFREE |
In conclusion, a five-locus interaction exists among IL4 -590C>T, FCER1B E237G, CD14 -159C>T, IL4RA Q551R and ADRB2 R16G in Filipino cases of atopic allergy.
|
25876437 |
2015 |
|
Hypotension, Orthostatic
|
|
0.010 |
GeneticVariation
|
BEFREE |
The association of β2 -AR Arg16/Gly with OH was not significant after adjustment for conventional risk factors.
|
24552127 |
2014 |
|
Mild persistent asthma
|
|
0.010 |
GeneticVariation
|
BEFREE |
The effects of a Gly16Arg ADRB2 polymorphism on responses to salmeterol or montelukast in Japanese patients with mild persistent asthma.
|
24681963 |
2014 |
|
Metabolic Syndrome X
|
|
0.010 |
GeneticVariation
|
BEFREE |
ADRB2 haplotypes (comprising rs1042711, rs1801704, rs1042713 and rs1042714 in that order), genotyping and statistical analysis to evaluate associations with continuous variables and traits related to IR and MS in a PCOS population.
|
22900502 |
2013 |
|
Diabetes
|
|
0.010 |
GeneticVariation
|
BEFREE |
On the other hand, hypertensive cases, whether being isolated or associated with obesity and/or diabetes, showed a nonsignificant difference from controls in relation to all genotypic variants related to the ADRB2 G46A polymorphism (p>0.05).
|
22731644 |
2012 |
|
Diabetes Mellitus
|
|
0.010 |
GeneticVariation
|
BEFREE |
On the other hand, hypertensive cases, whether being isolated or associated with obesity and/or diabetes, showed a nonsignificant difference from controls in relation to all genotypic variants related to the ADRB2 G46A polymorphism (p>0.05).
|
22731644 |
2012 |
|
Wheezing
|
|
0.010 |
GeneticVariation
|
BEFREE |
ADRB2 Arg16Gly showed a significant interactive effect with home dampness on being awakened at night due to wheezing and current wheezing, but no significant effect on active asthma and medication use.
|
22883364 |
2012 |
|
Pancreatic Insufficiency
|
|
0.010 |
GeneticVariation
|
BEFREE |
The Arg16Gly polymorphism in ADRB2 gene was associated with pancreatic insufficiency(p:0.009), Bhalla score(p:0.039), forced expiratory volume in the first second[FEV1(%)](p:0.003), forced expiratory flow between 25 and 75% of the forced vital capacity-FVC[FEF25-75(%)](p:0.008) and lower age at the first isolation of the Pseudomonas aeruginosa(p:0.012).
|
22950544 |
2012 |
|
Exocrine pancreatic insufficiency
|
|
0.010 |
GeneticVariation
|
BEFREE |
The Arg16Gly polymorphism in ADRB2 gene was associated with pancreatic insufficiency(p:0.009), Bhalla score(p:0.039), forced expiratory volume in the first second[FEV1(%)](p:0.003), forced expiratory flow between 25 and 75% of the forced vital capacity-FVC[FEF25-75(%)](p:0.008) and lower age at the first isolation of the Pseudomonas aeruginosa(p:0.012).
|
22950544 |
2012 |
|
Aspirin exacerbated respiratory disease
|
|
0.010 |
GeneticVariation
|
BEFREE |
We were the first to analyze Arg16Gly ADRB2 gene polymorphism in Japanese patients with AERD, and showed that Arg16Gly ADRB2 gene polymorphism in Japanese patients with AERD is different from that in the patients with ATA.
|
21829036 |
2011 |
|
Cerebrovascular accident
|
|
0.010 |
GeneticVariation
|
BEFREE |
A recessive model demonstrated a significant association between Arg16/Gly and: absolute supine and upright HR; HUT-induced change in cardiac index (CI), stroke index (SI) and systemic vascular resistance (SVR); and supine and upright norepinephrine values.
|
21807569 |
2011 |
|
Ataxia Telangiectasia
|
|
0.010 |
GeneticVariation
|
BEFREE |
We were the first to analyze Arg16Gly ADRB2 gene polymorphism in Japanese patients with AERD, and showed that Arg16Gly ADRB2 gene polymorphism in Japanese patients with AERD is different from that in the patients with ATA.
|
21829036 |
2011 |
|
Signs and Symptoms, Respiratory
|
|
0.010 |
GeneticVariation
|
BEFREE |
Moreover, in subjects with the AG or GG genotype at 46 A>G and haplotype [GAA] of ADRB2, the prevalence rates of wheat-specific IgG1 antibodies and lower respiratory symptoms increased significantly with exposure intensity (both p<0.05).
|
21488193 |
2011 |
|
Kidney Failure, Chronic
|
|
0.010 |
GeneticVariation
|
BEFREE |
We extended our findings to an independent case/control sample of Black hypertensive ESRD, in which we found that variant Gly16Arg that tagged the GFR slope-determining ADRB2 haplotype also conferred risk for the ESRD trait in Blacks.
|
20484896 |
2010 |
|
High altitude pulmonary edema
|
|
0.010 |
GeneticVariation
|
BEFREE |
The haplotypes from 46A/G and 79C/G SNP of ADRB2 were associated with HAPE.
|
20546540 |
2010 |
|
Chronic kidney disease stage 5
|
|
0.010 |
GeneticVariation
|
BEFREE |
We extended our findings to an independent case/control sample of Black hypertensive ESRD, in which we found that variant Gly16Arg that tagged the GFR slope-determining ADRB2 haplotype also conferred risk for the ESRD trait in Blacks.
|
20484896 |
2010 |