|
Nephrotic Syndrome, Minimal Change
|
|
0.030 |
GeneticVariation
|
BEFREE |
The purpose of the study was to investigate the distribution of insertion/deletion (I/D) polymorphisms of the angiotensin-converting enzyme (ACE) gene and three exonic polymorphisms of the multidrug resistance 1 (MDR1) gene (C3435T, C1236T, and G2677T) in children diagnosed with idiopathic nephrotic syndrome (INS).
|
26154535 |
2015 |
|
Idiopathic Nephrotic Syndrome
|
|
0.030 |
GeneticVariation
|
BEFREE |
The role of the multidrug resistance-1 (MDR1 or ABCB1) gene polymorphisms 1236T>C, 2677T>G, and 3435T>C was studied in relation to susceptibility, demographics, and pathological characteristics, as well as their role in the therapeutic response (TR) to prednisone treatment in children with idiopathic nephrotic syndrome (INS).
|
25559283 |
2015 |
|
Nephrotic Syndrome, Minimal Change
|
|
0.030 |
GeneticVariation
|
BEFREE |
The role of the multidrug resistance-1 (MDR1 or ABCB1) gene polymorphisms 1236T>C, 2677T>G, and 3435T>C was studied in relation to susceptibility, demographics, and pathological characteristics, as well as their role in the therapeutic response (TR) to prednisone treatment in children with idiopathic nephrotic syndrome (INS).
|
25559283 |
2015 |
|
Idiopathic Nephrotic Syndrome
|
|
0.030 |
GeneticVariation
|
BEFREE |
The purpose of the study was to investigate the distribution of insertion/deletion (I/D) polymorphisms of the angiotensin-converting enzyme (ACE) gene and three exonic polymorphisms of the multidrug resistance 1 (MDR1) gene (C3435T, C1236T, and G2677T) in children diagnosed with idiopathic nephrotic syndrome (INS).
|
26154535 |
2015 |
|
Malignant neoplasm of breast
|
|
0.030 |
GeneticVariation
|
BEFREE |
In this study, we examined the association between polymorphisms 3435 C/T and 1236 C/T in the ABCB1 gene and breast cancer development in Mexican women according to their menopausal status and molecular classification.
|
25730063 |
2015 |
|
Childhood Acute Lymphoblastic Leukemia
|
|
0.030 |
GeneticVariation
|
BEFREE |
C3435T and C1236T MDR1 polymorphism are significantly associated with the high-risk group (OR=2.6, 95%CI=1.164-5.808; P=0.028 and OR=2.231, 95%CI=1.068-4.659; p=0.047, respectively), indicating that both may be candidates for molecular markers in the high-risk group of ALL.
|
25854371 |
2015 |
|
Crohn Disease
|
|
0.030 |
GeneticVariation
|
BEFREE |
The CC genotypes of rs1128503 and rs1045642 in MDR1 gene were more frequent in Crohn's disease (CD) patients who were GC-dependent than in those responsive to GC (odds ratio [OR] 6.583, 95% confidence interval [CI] 1.760-24.628, P = 0.019 and OR 3.873, 95% CI 1.578-9.506, P = 0.009, respectively).
|
25346426 |
2015 |
|
Alzheimer's Disease
|
|
0.030 |
GeneticVariation
|
BEFREE |
To evaluate the association of ATP-binding cassette subfamily B member 1 (ABCB1) genetic variants with the susceptibility to Alzheimer's disease (AD), we genotyped the rs1128503 (C1236T), rs2032582 (G2677T/A), and rs1045642 (C3435T) polymorphisms in a case-control sample (234 AD patients, 225 controls).
|
25273678 |
2014 |
|
Epilepsy
|
|
0.030 |
GeneticVariation
|
BEFREE |
Our findings suggest that the ABCB1 rs3789243 C>T, C1236T, G2677T/A, rs6949448 C>T, and C3435T haplotypes do not contribute to response to AED treatment in epilepsy.
|
21530324 |
2011 |
|
Epilepsy
|
|
0.030 |
GeneticVariation
|
BEFREE |
In this study, we analyzed whether the three single nucleotide polymorphisms (C1236T, G2677T/A, and C3435T) in the ABCB1 gene were associated with pharmacoresistant epilepsy in a western Chinese pediatric population.
|
21420937 |
2011 |
|
Alzheimer's Disease
|
|
0.030 |
GeneticVariation
|
BEFREE |
Fifty-four Italian patients diagnosed with probable mild to moderate Alzheimer's disease, treated with donepezil (37 patients 5 mg/day, 17 patients 10 mg/day) were genotyped for CYP3A4 (*1B, *3, and *4), CYP3A5 (*2, *3, and *6) and ABCB1 (3435C>T, 2677G>T/A, and 1236C>T) polymorphisms.
|
20931330 |
2011 |
|
Malignant neoplasm of breast
|
|
0.030 |
GeneticVariation
|
BEFREE |
Whether ABCB1 polymorphisms including T-129C, A61G, C1236T, G2677T/A and C3435T polymorphisms could account for variations in the disposition of docetaxel and whether menopausal status at the time of diagnosis might interact with this effect were analysed in women receiving neoadjuvant chemotherapy for breast cancer (n=86).
|
20628376 |
2010 |
|
Crohn Disease
|
|
0.030 |
GeneticVariation
|
BEFREE |
Five SNPs, rs1128503 (P = 0.02), rs1202184 (P = 0.008), rs1202186 (P = 0.02), rs2091766 (P = 0.03), and rs2235046 (P = 0.03) were nominally associated with noninflammatory CD.
|
19107781 |
2009 |
|
Epilepsy
|
|
0.030 |
GeneticVariation
|
BEFREE |
Our aim was to investigate the effect of the 1236C>T(rs1128503), 2677G>T/A(rs2032582), and 3435C>T(rs1045642) single-nucleotide polymorphisms of ABCB1 (or MDR1) on drug resistance in north Indian patients with epilepsy.
|
18812236 |
2009 |
|
Childhood Acute Lymphoblastic Leukemia
|
|
0.030 |
GeneticVariation
|
BEFREE |
Overall, the SNPs considered individually or within haplotypes (C1236T-G2677T/A-C3435T) were not significantly associated with childhood ALL.
|
17548681 |
2007 |
|
Parkinson Disease
|
|
0.030 |
GeneticVariation
|
BEFREE |
The frequency of each individual SNPs; -41 A > G (intron -1), -145 C > G (exon 1), -129 T > C (exon 1), 1236 T > C (exon 12), 2677 G > T/A (exon 21), 3435 C > T (exon 26), and 4036 A > G (exon 28) did not differ between PD and controls.
|
15542248 |
2004 |
|
Glioblastoma
|
|
0.020 |
GeneticVariation
|
BEFREE |
In conclusion, in patients with GBM receiving RCT with TMZ, no correlation with survival was found for the SNV:s 1236C>T, 2677G>T/A, and 3435C>T of ABCB1.
|
31624332 |
2020 |
|
Glioblastoma Multiforme
|
|
0.020 |
GeneticVariation
|
BEFREE |
In conclusion, in patients with GBM receiving RCT with TMZ, no correlation with survival was found for the SNV:s 1236C>T, 2677G>T/A, and 3435C>T of ABCB1.
|
31624332 |
2020 |
|
Major Depressive Disorder
|
|
0.020 |
GeneticVariation
|
BEFREE |
MDD is associated with the rs2032582 (<i>G2677T</i>) and rs1128503 (<i>C1236T</i>) single-nucleotide polymorphisms (SNPs) of <i>ABCB1</i> but not with rs1045642, rs2032583, rs2235040, and rs2235015.
|
31333472 |
2019 |
|
Neoplasms
|
|
0.020 |
GeneticVariation
|
BEFREE |
CC and TC+TT genotype patients with C1236T loci showed statistically significant differences in tumor size stratification (χ=4.006, P=0.045).
|
30779721 |
2019 |
|
Osteosarcoma
|
|
0.020 |
GeneticVariation
|
BEFREE |
The <i>ABCB1</i> (C1236T) polymorphism affects P-gp-mediated transport of osteosarcoma drugs in a drug-specific way.
|
30977678 |
2019 |
|
Osteosarcoma of bone
|
|
0.020 |
GeneticVariation
|
BEFREE |
The <i>ABCB1</i> (C1236T) polymorphism affects P-gp-mediated transport of osteosarcoma drugs in a drug-specific way.
|
30977678 |
2019 |
|
Liver carcinoma
|
|
0.020 |
GeneticVariation
|
BEFREE |
C1236T genotype may predict changes in pathological features of patients with HCC to a certain extent, and C3435T SNP can be used as one of the prognostic factors of HCC.
|
30779721 |
2019 |
|
Childhood Osteosarcoma
|
|
0.020 |
GeneticVariation
|
BEFREE |
The <i>ABCB1</i> (C1236T) polymorphism affects P-gp-mediated transport of osteosarcoma drugs in a drug-specific way.
|
30977678 |
2019 |
|
Neoplasms
|
|
0.020 |
GeneticVariation
|
BEFREE |
The tumour response to docetaxel was significantly influenced by the SNP C1236T of ABCB1 gene coding for the P-gp.
|
30637776 |
2019 |