|
Acute leukemia
|
|
0.010 |
GeneticVariation
|
BEFREE |
The aim of the study was to evaluate bone marrow and peripheral blood leptin level and frequency of distribution of leptin receptor gene polymorphism Gln223Arg in children with acute leukemia.
|
17072067 |
2006 |
|
Alzheimer Disease, Late Onset
|
|
0.010 |
GeneticVariation
|
BEFREE |
Our preliminary data showed no significant association between the LEPR Gln223Arg polymorphism and LOAD (genotype distribution: chi=0.11, df=2, P=0.945; allele frequency: chi=0.058, df=1, P=0.81, odds ratio=1.08, 95% confidence interval=0.59 to 2.03).
|
20220325 |
2010 |
|
Alzheimer's Disease
|
|
0.010 |
GeneticVariation
|
BEFREE |
The LEPR Gln223Arg polymorphism may thus play an important role in the pathogenesis of AD.
|
20220325 |
2010 |
|
Amebiasis
|
|
0.010 |
GeneticVariation
|
BEFREE |
Humans with the Q223R leptin receptor mutation have increased susceptibility to amebiasis, but the mechanism has been unclear.
|
25516614 |
2014 |
|
Amebic colitis
|
|
0.010 |
GeneticVariation
|
BEFREE |
Humans with the Q223R leptin receptor mutation have increased susceptibility to amebiasis, but the mechanism has been unclear.
|
25516614 |
2014 |
|
Arteriosclerosis
|
|
0.010 |
GeneticVariation
|
BEFREE |
Leptin receptor Lys109Arg and Gln223Arg polymorphisms are associated with early atherosclerosis.
|
20874424 |
2010 |
|
Asthma
|
|
0.010 |
GeneticVariation
|
BEFREE |
No association with asthma was observed for the K109R and the Q223R polymorphisms of the LEPR gene and the Met72Leu polymorphism of the ghrelin gene.
|
19191138 |
2009 |
|
Atherosclerosis
|
|
0.010 |
GeneticVariation
|
BEFREE |
Leptin receptor Lys109Arg and Gln223Arg polymorphisms are associated with early atherosclerosis.
|
20874424 |
2010 |
|
Breast Carcinoma
|
|
0.080 |
GeneticVariation
|
BEFREE |
This article suggests that the A allele of LEPR gene rs1137101 variant was low-penetrant risk factor for developing breast cancer.The result is encouraging.
|
25863476 |
2015 |
|
Breast Carcinoma
|
|
0.080 |
GeneticVariation
|
BEFREE |
In conclusion, LEP G2548A polymorphism has no relationship with BC susceptibility, while LEPR Q223R polymorphism could decrease BC risk in Asians, but not in overall individuals and Caucasians.
|
28938640 |
2017 |
|
Breast Carcinoma
|
|
0.080 |
GeneticVariation
|
BEFREE |
This meta-analysis enrolled eight studies to estimate the overall risk of LEPR Gln223Arg polymorphism associated with breast cancer.
|
21698367 |
2012 |
|
Breast Carcinoma
|
|
0.080 |
GeneticVariation
|
BEFREE |
Overall, the results showed null significant association between LEP G2548A, LEPR Q223R, LEPR Lys109Arg, or PON1 Q192R polymorphism and breast cancer risk; however, PON1 L55M was significantly associated with breast cancer risk overall (MM vs. LL: OR = 2.16; 95% CI, 1.76-2.66).
|
21887553 |
2011 |
|
Breast Carcinoma
|
|
0.080 |
GeneticVariation
|
BEFREE |
Moreover, there were significant association between the Gln223Arg genotype and breast cancer risk; homozygotes for AA and heterozygotes for AG,AG + GG genotypes had been proved to increase the risk of b</span>reast cancer, and their corresponding odds ratio were 7.14 (95% confidence interval [CI] = 1.92-25.64), 1.33(95% CI = 1.03-2.70), and 2.04 (95% CI = 1.09-3.82).
|
18668212 |
2008 |
|
Breast Carcinoma
|
|
0.080 |
GeneticVariation
|
BEFREE |
In the stratified analysis, there was no significant association of LEPR Q223R variant with breast cancer, colorectal cancer and non-Hodgkin's lymphoma (NHL) under any models.
|
25261679 |
2014 |
|
Breast Carcinoma
|
|
0.080 |
GeneticVariation
|
BEFREE |
We utilized a polymerase chain reaction (PCR)-based restriction fragment length polymorphism (RFLP) assay to evaluate the association between the Gln223Arg polymorphism of the leptin receptor gene and breast risk in Nigeria in a case control study involving 209 women with breast cancer and 209 controls without the disease.
|
19017403 |
2008 |
|
Breast Carcinoma
|
|
0.080 |
GeneticVariation
|
BEFREE |
This pooled analysis suggested that rs1137101 and rs1137100 polymorphisms were significantly correlated with breast cancer risk and the A allele of LEPR rs1137101 variant and the G allele of LEPR rs1137100 variant were low-penetrant risk factors for developing breast cancer.
|
22983835 |
2012 |
|
Carcinoma of lung
|
|
0.010 |
GeneticVariation
|
BEFREE |
As a result, susceptibility effects of LEP -2548G > A polymorphism alone or in combination with LEPR Q223R polymorphism on lung cancer were observed.
|
25027400 |
2014 |
|
Cardiovascular Diseases
|
|
0.020 |
GeneticVariation
|
BEFREE |
Single-nucleotide polymorphisms (SNPs) rs7799039 and rs1137101 in leptin (LEP) and leptin receptor (LEPR) genes, respectively, are associated with cardiovascular disease and metabolic syndrome.
|
27310420 |
2017 |
|
Cardiovascular Diseases
|
|
0.020 |
GeneticVariation
|
BEFREE |
Two leptin receptor single nucleotide polymorphisms, Lys109Arg and Gln223Arg, have been shown to associate with several risk factors for cardiovascular disease.
|
24140454 |
2014 |
|
Childhood Acute Lymphoblastic Leukemia
|
|
0.020 |
GeneticVariation
|
BEFREE |
Polymorphisms of leptin gene -18G > A and leptin receptor genes K109R and Q223R were not associated with overweight status in ALL survivors.
|
21631924 |
2011 |
|
Childhood Acute Lymphoblastic Leukemia
|
|
0.020 |
GeneticVariation
|
BEFREE |
Because radiation at a young age may affect the hypothalamus causing leptin receptor insensitivity, we hypothesized that a polymorphism in the leptin receptor (LEPR) gene, Gln223Arg, might influence susceptibility to obesity in survivors of childhood ALL.
|
15337805 |
2004 |
|
Congestive heart failure
|
|
0.010 |
GeneticVariation
|
BEFREE |
In subanalyses according to CHF etiology the LEPR Gln223Arg showed an independent prediction role for NYHA IV in IHD patients (P = 0.0001, OR = 2.50, 95% CI = 1.69-3.82) and both for NYHA IV(P = 0.007, OR = 2.04, 95% CI = 1.20-3.84) and LVEF (P = 0.004, OR = 11.87, 95% CI = 2.08-55.6) in DCMP patients.
|
19337797 |
2009 |
|
Conventional (Clear Cell) Renal Cell Carcinoma
|
|
0.020 |
GeneticVariation
|
BEFREE |
GG genotype is associated with more aggressive tumor behavior and shorter survival compared with GA & AA genotypes so, genotyping of Gln223Arg (A/G) rs1137101 could also predict RCC outcome.
|
29453609 |
2018 |
|
Conventional (Clear Cell) Renal Cell Carcinoma
|
|
0.020 |
GeneticVariation
|
BEFREE |
Our data suggest that the GG/GG combined genotype and G-G haplotype of Lys109Arg and Gln223Arg can act as evaluating factors for CC-RCC risk.
|
24935373 |
2014 |
|
Coronary Artery Disease
|
|
0.020 |
GeneticVariation
|
BEFREE |
However, no positive findings were observed for <i>LEPR</i> rs1137100 and rs1137101 variants in overall and subgroup analyses.<b>Conclusions:</b> Our meta-analysis suggested that <i>LEP</i> rs7799039 variant might affect individual susceptibility to CAD.
|
31113873 |
2019 |