|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
These findings support the hypothesis that the Q223R polymorphism (but not the K109R or K656N polymorphism) of the leptin receptor gene is associated with obesity and predicts a small percentage of body weight and body composition variability in a genetically homogeneous population.
|
11549688 |
2001 |
|
Impaired glucose tolerance
|
|
0.020 |
GeneticVariation
|
BEFREE |
In postmenopausal women with IGT (n = 24), associations were found with Lys(109)Arg and Lys(656)Asn for fasting insulin (P = 0.05) and with Lys(109)Arg and Gln(223)Arg for the insulin response to an OGTT (P < 0.02).
|
11443193 |
2001 |
|
Prostate carcinoma
|
|
0.020 |
GeneticVariation
|
BEFREE |
The Lys109Arg (OBR1) and Gln223Arg (OBR2) polymorphisms in the coding region of OBR were studied in blood DNA from 271 patients with prostate cancer aged < 56 years at diagnosis and 277 geographically matched control subjects.
|
12823393 |
2003 |
|
Malignant neoplasm of prostate
|
|
0.020 |
GeneticVariation
|
BEFREE |
The Lys109Arg (OBR1) and Gln223Arg (OBR2) polymorphisms in the coding region of OBR were studied in blood DNA from 271 patients with prostate cancer aged < 56 years at diagnosis and 277 geographically matched control subjects.
|
12823393 |
2003 |
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
Obesity-related genetic factors including common polymorphisms in the leptin gene (LEP A19G and G-2548A) and its receptor (LEPR Q223R) were investigated in DNA available for 376 patients and 805 controls.
|
15159310 |
2004 |
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
Because radiation at a young age may affect the hypothalamus causing leptin receptor insensitivity, we hypothesized that a polymorphism in the leptin receptor (LEPR) gene, Gln223Arg, might influence susceptibility to obesity in survivors of childhood ALL.
|
15337805 |
2004 |
|
Childhood Acute Lymphoblastic Leukemia
|
|
0.020 |
GeneticVariation
|
BEFREE |
Because radiation at a young age may affect the hypothalamus causing leptin receptor insensitivity, we hypothesized that a polymorphism in the leptin receptor (LEPR) gene, Gln223Arg, might influence susceptibility to obesity in survivors of childhood ALL.
|
15337805 |
2004 |
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
To conclude, our results support the hypothesis that Gln223Arg</span> polymorphism of LEPR in Mexican adolescents is associated with haemodynamic and metabolic disturbances related to obesity.
|
15660115 |
2005 |
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
Some polymorphic genes involved in the regulation of leptin-the leptin gene (LEP A19G), the leptin receptor gene (LEPR Q223R, K109R, and K656N), and the peroxisome proliferator-activated receptor-gamma gene (PPARG P12A and C161T)--have been investigated as possible factors associated with obesity.
|
15972940 |
2005 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.040 |
GeneticVariation
|
BEFREE |
Two polymorphisms (Lys109Arg, Gln223Arg) in the extracellular domain of the leptin receptor predicted the conversion to type 2 diabetes in high-risk individuals with IGT.
|
15997246 |
2005 |
|
Impaired glucose tolerance
|
|
0.020 |
GeneticVariation
|
BEFREE |
Two polymorphisms (Lys109Arg, Gln223Arg) in the extracellular domain of the leptin receptor predicted the conversion to type 2 diabetes in high-risk individuals with IGT.
|
15997246 |
2005 |
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
There was a significant difference in LEPR p.Q223</span>R polymorphism frequency when comparing obese and lean subjects, with an odds ratio of 1.92 and a 95% confidence interval of 1.15-3.22 (P = 0.013).
|
16788891 |
2006 |
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
The inverse association between the Q223R polymorphism and obesity</span> (OR = 0.62; 95% CI: 0.39-0.99) remained significant even after additional adjustment for education, tobacco smoking, alcohol, physical activity, origin of the obese patient, and the -2548G > A polymorphism in the LEP gene (OR = 0.54; 95% CI: 0.32-0.89).
|
17031518 |
2006 |
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
We examined the genetic associations of the G-2548A polymorphism in the promoter of the leptin (LEP) gene and the Gln223Arg (Q223R) polymorphism of the leptin receptor (LEPR) gene with obesity.
|
16571841 |
2006 |
|
Hyperlipidemia, Familial Combined
|
|
0.010 |
GeneticVariation
|
BEFREE |
The Gln223Arg polymorphism in the leptin receptor is associated with familial combined hyperlipidemia.
|
16432543 |
2006 |
|
Acute leukemia
|
|
0.010 |
GeneticVariation
|
BEFREE |
The aim of the study was to evaluate bone marrow and peripheral blood leptin level and frequency of distribution of leptin receptor gene polymorphism Gln223Arg in children with acute leukemia.
|
17072067 |
2006 |
|
Nuchal bleb, familial
|
|
0.010 |
GeneticVariation
|
BEFREE |
The Gln223Arg polymorphism in the LEPR gene is associated with FCH, which is supported by a significant association between HDL-c levels and the LEPR gene.
|
16432543 |
2006 |
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
The haplotype combination of LEP c.-2548G>A and LEPR p.Q223R</span> variants was related to a 58% increase in obesity risk.
|
18273796 |
2007 |
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
The aim of this study was to determine the incidence of the following polymorphisms in the following genes in 262 obese (BMI > or = 30) and 138 control (BMI < or = 25) subjects: leptin receptor (LEPR)-Gln223Arg, B3-adrenergic receptor (B3-AR)-Trp64Arg, serotonin transporter (5-HTT)--a 44-base pair insertion/deletion functional polymorphism in the 5-HTTLPR and insulin receptor substrate-1 (IRS-1)-Gly972Arg.
|
17124363 |
2007 |
|
Sleep Apnea, Obstructive
|
|
0.060 |
GeneticVariation
|
BEFREE |
The aim of the present study was to evaluate the frequency of distribution of leptin receptor gene polymorphism GLN223ARG in OSAS patients compared with healthy controls.
|
18204169 |
2007 |
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
Overweight-obese subjects had significantly higher frequencies of the Arg223 allele and the Arg223 homozygous allele of Gln223Arg and the Asn656 allele of Lys656Asn compared to lean subjects.
|
18716356 |
2008 |
|
Malignant neoplasm of breast
|
|
0.080 |
GeneticVariation
|
BEFREE |
We utilized a polymerase chain reaction (PCR)-based restriction fragment length polymorphism (RFLP) assay to evaluate the association between the Gln223Arg polymorphism of the leptin receptor gene and breast risk in Nigeria in a case control study involving 209 women with breast cancer and 209 controls without the disease.
|
19017403 |
2008 |
|
Breast Carcinoma
|
|
0.080 |
GeneticVariation
|
BEFREE |
Moreover, there were significant association between the Gln223Arg genotype and breast cancer risk; homozygotes for AA and heterozygotes for AG,AG + GG genotypes had been proved to increase the risk of b</span>reast cancer, and their corresponding odds ratio were 7.14 (95% confidence interval [CI] = 1.92-25.64), 1.33(95% CI = 1.03-2.70), and 2.04 (95% CI = 1.09-3.82).
|
18668212 |
2008 |
|
Breast Carcinoma
|
|
0.080 |
GeneticVariation
|
BEFREE |
We utilized a polymerase chain reaction (PCR)-based restriction fragment length polymorphism (RFLP) assay to evaluate the association between the Gln223Arg polymorphism of the leptin receptor gene and breast risk in Nigeria in a case control study involving 209 women with breast cancer and 209 controls without the disease.
|
19017403 |
2008 |
|
Malignant neoplasm of breast
|
|
0.080 |
GeneticVariation
|
BEFREE |
Moreover, there were significant association between the Gln223Arg genotype and breast cancer risk; homozygotes for AA and heterozygotes for AG,AG + GG genotypes had been proved to increase the risk of b</span>reast cancer, and their corresponding odds ratio were 7.14 (95% confidence interval [CI] = 1.92-25.64), 1.33(95% CI = 1.03-2.70), and 2.04 (95% CI = 1.09-3.82).
|
18668212 |
2008 |