|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
Obesity-related genetic factors including common polymorphisms in the leptin gene (LEP A19G and G-2548A) and its receptor (LEPR Q223R) were investigated in DNA available for 376 patients and 805 controls.
|
15159310 |
2004 |
|
Malignant Neoplasms
|
|
0.040 |
GeneticVariation
|
BEFREE |
Among cases, 14 SNPs of the LEPR gene were significantly associated with cancer grade, and rs1137101 (Q223R) survived multiple testing adjustment (adjusted P = 0.04).
|
21947707 |
2012 |
|
Primary malignant neoplasm
|
|
0.040 |
GeneticVariation
|
BEFREE |
Among cases, 14 SNPs of the LEPR gene were significantly associated with cancer grade, and rs1137101 (Q223R) survived multiple testing adjustment (adjusted P = 0.04).
|
21947707 |
2012 |
|
Non-alcoholic Fatty Liver Disease
|
|
0.030 |
GeneticVariation
|
BEFREE |
And LEPR Q223R might be a susceptible factor for NAFLD in Chinese population.
|
29974828 |
2018 |
|
Malignant neoplasm of lung
|
|
0.010 |
GeneticVariation
|
BEFREE |
As a result, susceptibility effects of LEP -2548G > A polymorphism alone or in combination with LEPR Q223R polymorphism on lung cancer were observed.
|
25027400 |
2014 |
|
Carcinoma of lung
|
|
0.010 |
GeneticVariation
|
BEFREE |
As a result, susceptibility effects of LEP -2548G > A polymorphism alone or in combination with LEPR Q223R polymorphism on lung cancer were observed.
|
25027400 |
2014 |
|
Primary malignant neoplasm of lung
|
|
0.010 |
GeneticVariation
|
BEFREE |
As a result, susceptibility effects of LEP -2548G > A polymorphism alone or in combination with LEPR Q223R polymorphism on lung cancer were observed.
|
25027400 |
2014 |
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
As regards, rs7799039 AA genotype showed significant higher leptin level than other genotypes in the same group with a non-significant difference in genotypes distribution between obese and controls. rs1137101 variant of leptin receptor and fasting leptin level are correlated with overweight and obesity in Saudi children.
|
29412799 |
2018 |
|
Overweight and obesity
|
|
0.020 |
GeneticVariation
|
BEFREE |
As regards, rs7799039 AA genotype showed significant higher leptin level than other genotypes in the same group with a non-significant difference in genotypes distribution between obese and controls. rs1137101 variant of leptin receptor and fasting leptin level are correlated with overweight and obesity in Saudi children.
|
29412799 |
2018 |
|
Hypertensive left ventricular hypertrophy
|
|
0.010 |
GeneticVariation
|
BEFREE |
Association of Gln223Arg polymorphism of the leptin receptor with hypertensive left ventricular hypertrophy.
|
24485307 |
2013 |
|
Osteoarthritis, Knee
|
|
0.010 |
GeneticVariation
|
BEFREE |
Association of rs1137101 polymorphism in LEPR and susceptibility to knee osteoarthritis in a Northwest Chinese Han population.
|
27457563 |
2016 |
|
Lip and Oral Cavity Carcinoma
|
|
0.020 |
GeneticVariation
|
BEFREE |
Association of leptin -2548G/A and leptin receptor Q223R polymorphisms with increased risk for oral cancer.
|
18855010 |
2009 |
|
Malignant neoplasm of mouth
|
|
0.020 |
GeneticVariation
|
BEFREE |
Association of leptin -2548G/A and leptin receptor Q223R polymorphisms with increased risk for oral cancer.
|
18855010 |
2009 |
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
Association of two obesity-related gene polymorphisms LEPG2548A rs7799039 and LEPRQ223R rs1137101 with the risk of breast cancer.
|
28938640 |
2017 |
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
Because radiation at a young age may affect the hypothalamus causing leptin receptor insensitivity, we hypothesized that a polymorphism in the leptin receptor (LEPR) gene, Gln223Arg, might influence susceptibility to obesity in survivors of childhood ALL.
|
15337805 |
2004 |
|
Childhood Acute Lymphoblastic Leukemia
|
|
0.020 |
GeneticVariation
|
BEFREE |
Because radiation at a young age may affect the hypothalamus causing leptin receptor insensitivity, we hypothesized that a polymorphism in the leptin receptor (LEPR) gene, Gln223Arg, might influence susceptibility to obesity in survivors of childhood ALL.
|
15337805 |
2004 |
|
Somatotropin deficiency
|
|
0.020 |
GeneticVariation
|
BEFREE |
CONCLUSIONS Gene polymorphism of leptin (loci rs7799039) and leptin receptor (loci rs</span>1137101) are correlated with GHD susceptibility.
|
26915772 |
2016 |
|
Polycystic Ovary Syndrome
|
|
0.040 |
GeneticVariation
|
BEFREE |
Despite previous suggestion about a relationship between rs1137101, serum leptin levels, and PCOS, our studies do not show any statistical association and further investigations; possibly by also evaluating obese patients should be needed to elucidate this issue better.
|
30635060 |
2019 |
|
Hyperlipidemia
|
|
0.010 |
GeneticVariation
|
BEFREE |
Effects of LEP G2548A and LEPR Q223R Polymorphisms on Serum Lipids and Response to Simvastatin Treatment in Chinese Patients With Primary Hyperlipidemia.
|
26984935 |
2017 |
|
Malignant Neoplasms
|
|
0.040 |
GeneticVariation
|
BEFREE |
For LEPR Q223R, no statistical evidence for an association with risk of cancer was found for all; however, further stratification by ethnicity showed an increased risk for Africans but not for other ethnicities.
|
24146750 |
2013 |
|
Primary malignant neoplasm
|
|
0.040 |
GeneticVariation
|
BEFREE |
For LEPR Q223R, no statistical evidence for an association with risk of cancer was found for all; however, further stratification by ethnicity showed an increased risk for Africans but not for other ethnicities.
|
24146750 |
2013 |
|
Squamous cell carcinoma of oropharynx
|
|
0.010 |
GeneticVariation
|
BEFREE |
Furthermore, several studies have shown a relationship between the Gln223Arg polymorphism and tumor development, and its role in oral and oropharyngeal squamous cell carcinoma is now well understood.
|
26634459 |
2015 |
|
Conventional (Clear Cell) Renal Cell Carcinoma
|
|
0.020 |
GeneticVariation
|
BEFREE |
GG genotype is associated with more aggressive tumor behavior and shorter survival compared with GA & AA genotypes so, genotyping of Gln223Arg (A/G) rs1137101 could also predict RCC outcome.
|
29453609 |
2018 |
|
Renal Cell Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
GG genotype is associated with more aggressive tumor behavior and shorter survival compared with GA & AA genotypes so, genotyping of Gln223Arg (A/G) rs1137101 could also predict RCC outcome.
|
29453609 |
2018 |
|
Neoplasms
|
|
0.020 |
GeneticVariation
|
BEFREE |
GG genotype is associated with more aggressive tumor behavior and shorter survival compared with GA & AA genotypes so, genotyping of Gln223Arg (A/G) rs1137101 could also predict RCC outcome.
|
29453609 |
2018 |