|
Post transplant diabetes mellitus
|
|
0.010 |
GeneticVariation
|
BEFREE |
KEY MESSAGES The <i>LEPR</i> Gln223Arg polymorphism significantly contributes to the development of PTDM in renal transplant recipients.
|
31046466 |
2019 |
|
Obstructive sleep apnea hypopnea syndrome
|
|
0.010 |
GeneticVariation
|
BEFREE |
Of the seven case-control studies we enrolled, there was insignificant correlation of the LEPR Gln223Arg polymorphism with OSAHS risk.
|
31679272 |
2019 |
|
Hyperglycemia
|
|
0.010 |
GeneticVariation
|
BEFREE |
To determine whether genetic polymorphisms related to pharmacodynamics with metabolic adverse effects, namely leptin promoter (<i>LEP</i>) rs7799039, leptin receptor rs1137101, dopamine D2 rs4436578, serotonin 5-HT2A rs6313, and serotonin 5-HT2C rs518147 and rs12836771, are associated with hyperglycemia induced by risperidone or clozapine in adult Thai patients with psychosis.
|
31496784 |
2019 |
|
Nonorganic psychosis
|
|
0.010 |
GeneticVariation
|
BEFREE |
To determine whether genetic polymorphisms related to pharmacodynamics with metabolic adverse effects, namely leptin promoter (<i>LEP</i>) rs7799039, leptin receptor rs1137101, dopamine D2 rs4436578, serotonin 5-HT2A rs6313, and serotonin 5-HT2C rs518147 and rs12836771, are associated with hyperglycemia induced by risperidone or clozapine in adult Thai patients with psychosis.
|
31496784 |
2019 |
|
Non-ST-segment elevation myocardial infarction (NSTEMI)
|
|
0.010 |
GeneticVariation
|
BEFREE |
Study of rs1137101 polymorphism of leptin receptor gene with serum levels of selenium and copper in the patients of non-ST-segment elevation myocardial infarction (NSTEMI) in an Iranian population.
|
29964004 |
2018 |
|
Non-ST Elevated Myocardial Infarction
|
|
0.010 |
GeneticVariation
|
BEFREE |
We find for the first time that there is a significant association between rs1137101 polymorphism and susceptibility to NSTEMI.
|
29964004 |
2018 |
|
Renal Cell Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
GG genotype is associated with more aggressive tumor behavior and shorter survival compared with GA & AA genotypes so, genotyping of Gln223Arg (A/G) rs1137101 could also predict RCC outcome.
|
29453609 |
2018 |
|
Hyperlipidemia
|
|
0.010 |
GeneticVariation
|
BEFREE |
Effects of LEP G2548A and LEPR Q223R Polymorphisms on Serum Lipids and Response to Simvastatin Treatment in Chinese Patients With Primary Hyperlipidemia.
|
26984935 |
2017 |
|
Squamous cell carcinoma of esophagus
|
|
0.010 |
GeneticVariation
|
BEFREE |
In addition, <i>LEPR</i> rs1137101 G>A polymorphism decreased ESCC risk in some subgroups (ever smoking subgroup: GA vs. GG: adjusted OR=0.66, 95%CI=0.44-1.00, <i>P</i>=0.049; ever drinking subgroup: GA vs. GG: adjusted OR=0.54, 95%CI=0.31-0.95, <i>P</i>=0.031 and GA/AA vs. GG: adjusted OR=0.54, 95%CI=0.31-0.93, <i>P</i>=0.027).
|
29312594 |
2017 |
|
Osteoarthritis, Knee
|
|
0.010 |
GeneticVariation
|
BEFREE |
Association of rs1137101 polymorphism in LEPR and susceptibility to knee osteoarthritis in a Northwest Chinese Han population.
|
27457563 |
2016 |
|
Degenerative polyarthritis
|
|
0.010 |
GeneticVariation
|
BEFREE |
Our finding suggested that the genetic variant of LEPR gene rs1137101 is independently related to knee OA susceptibility in Northwest Chinese population with Han ethnicity and may serve as a potential biomarker to determine risk of knee OA.
|
27457563 |
2016 |
|
Gestational Diabetes
|
|
0.010 |
GeneticVariation
|
BEFREE |
However, neither LEP G2548A nor LEPR Gln223Arg polymorphisms were significantly associated with GDM risk and plasma leptin levels (P > 0.05).
|
27034205 |
2016 |
|
Ischemic stroke
|
|
0.010 |
GeneticVariation
|
BEFREE |
Our data suggest that LEPR Lys109Arg and Gln223Arg polymorphisms could be used as genetic predictive factor for ischemic stroke.
|
26150085 |
2015 |
|
Hypercholesterolemia
|
|
0.010 |
GeneticVariation
|
BEFREE |
Similarly, LEPR 668 A/G + G/G carriers with a high fat total intake had 3.0 times higher risk of obesity (p = 0.002) and 4.1 times higher risk of hypercholesterolemia (p = 0.001).
|
26365669 |
2015 |
|
Squamous cell carcinoma of oropharynx
|
|
0.010 |
GeneticVariation
|
BEFREE |
Furthermore, several studies have shown a relationship between the Gln223Arg polymorphism and tumor development, and its role in oral and oropharyngeal squamous cell carcinoma is now well understood.
|
26634459 |
2015 |
|
Malignant neoplasm of oropharynx
|
|
0.010 |
GeneticVariation
|
BEFREE |
In conclusion, the Gln223Arg polymorphism and LEPR expression might be valuable markers for oral and oropharyngeal cancer, suggesting that LEPR might serve as a potential target for future therapies.
|
26634459 |
2015 |
|
Squamous cell carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
The incidence of leptin gene G2548A homozygous mutant AA polymorphism was significantly increased in the OSCC patients (p = 0.002, odds ratio (OR) = 2.4, 95 % confidence interval (CI) = 1.37-4.22) when compared with controls, and leptin receptor A668G homozygous mutant GG polymorphism was significantly high in the OSCC patients as compared to controls (p = 0.000, OR = 3.8, 95 % CI = 1.98-7.62).
|
25809704 |
2015 |
|
Hypertriglyceridemia
|
|
0.010 |
GeneticVariation
|
BEFREE |
We also found that A/G + G/G genotypes of the 668 A/G polymorphism in the LEPR gene with an intake ≥ 12 g/d of saturated fatty acids, have 2.9 times higher risk of obesity (p = 0.002), 3.8 times higher risk of hypercholesterolemia (p = 0.002) and 2.4 times higher risk of hypertriglyceridemia (p = 0.02), than those with an intake <12 g/d of saturated fatty acids.
|
26365669 |
2015 |
|
Oropharyngeal Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
In conclusion, the Gln223Arg polymorphism and LEPR expression might be valuable markers for oral and oropharyngeal cancer, suggesting that LEPR might serve as a potential target for future therapies.
|
26634459 |
2015 |
|
Gynecomastia
|
|
0.010 |
GeneticVariation
|
BEFREE |
Leptin receptor gene rs1137101 polymorphism might affect susceptibility to gynecomastia.
|
24625355 |
2014 |
|
Lymphoma, Non-Hodgkin
|
|
0.010 |
GeneticVariation
|
BEFREE |
In the stratified analysis, there was no significant association of LEPR Q223R variant with breast cancer, colorectal cancer and non-Hodgkin's lymphoma (NHL) under any models.
|
25261679 |
2014 |
|
Liver Abscess, Amebic
|
|
0.010 |
GeneticVariation
|
BEFREE |
We explored the distribution of Q223R mutation in leptin receptor gene of amoebic liver abscess (ALA) patients of North India.
|
25114924 |
2014 |
|
Amebiasis
|
|
0.010 |
GeneticVariation
|
BEFREE |
Humans with the Q223R leptin receptor mutation have increased susceptibility to amebiasis, but the mechanism has been unclear.
|
25516614 |
2014 |
|
Amebic colitis
|
|
0.010 |
GeneticVariation
|
BEFREE |
Humans with the Q223R leptin receptor mutation have increased susceptibility to amebiasis, but the mechanism has been unclear.
|
25516614 |
2014 |
|
Malignant neoplasm of lung
|
|
0.010 |
GeneticVariation
|
BEFREE |
As a result, susceptibility effects of LEP -2548G > A polymorphism alone or in combination with LEPR Q223R polymorphism on lung cancer were observed.
|
25027400 |
2014 |