|
Xeroderma pigmentosum, group F
|
|
0.020 |
GeneticVariation
|
BEFREE |
XPC (A2920C), XPF (T30028C), TP53 (Arg72Pro), and GSTP1 (Ile105Val) polymorphisms in prognosis of cutaneous melanoma.
|
26427666 |
2016 |
|
Xeroderma pigmentosum, group F
|
|
0.020 |
GeneticVariation
|
BEFREE |
Assessment of the XPC (A2920C), XPF (T30028C), TP53 (Arg72Pro) and GSTP1 (Ile105Val) polymorphisms in the risk of cutaneous melanoma.
|
23568549 |
2013 |
|
Xeroderma Pigmentosum, Complementation Group D
|
|
0.010 |
GeneticVariation
|
BEFREE |
The germline polymorphisms studied were thymidylate synthase, (VNTR/5'UTR, 2R G>C single nucleotide polymorphism [SNP], 3R G>C SNP), epidermal growth factor receptor (Arg497Lys), GSTP1 (Ile105val), excision repair cross-complementing 1 (Asn118Asn, 8092C>A, 19716G>C), X-ray repair cross-complementing group 1 (XRCC1) (Arg194Trp, Arg280His, Arg399Gln), and xeroderma pigmentosum group D (Lys751Gln).
|
21570215 |
2011 |
|
XERODERMA PIGMENTOSUM, COMPLEMENTATION GROUP C
|
|
0.020 |
GeneticVariation
|
BEFREE |
XPC (A2920C), XPF (T30028C), TP53 (Arg72Pro), and GSTP1 (Ile105Val) polymorphisms in prognosis of cutaneous melanoma.
|
26427666 |
2016 |
|
XERODERMA PIGMENTOSUM, COMPLEMENTATION GROUP C
|
|
0.020 |
GeneticVariation
|
BEFREE |
Assessment of the XPC (A2920C), XPF (T30028C), TP53 (Arg72Pro) and GSTP1 (Ile105Val) polymorphisms in the risk of cutaneous melanoma.
|
23568549 |
2013 |
|
Wheezing
|
|
0.020 |
GeneticVariation
|
BEFREE |
A suggestive interaction with early maternal smoking was also seen for three GSTP1 SNPs (Intron 5, Intron 6 and Ile105Val) with respect to transient wheeze, but not for ADRB2 and wheeze phenotypes.
|
20210814 |
2010 |
|
Wheezing
|
|
0.020 |
GeneticVariation
|
BEFREE |
Using SNP- and haplotype-based approaches, the effect of maternal smoking on wheezing was largest in children with the Ile105Val allele.
|
18335111 |
2008 |
|
Vomiting
|
|
0.010 |
GeneticVariation
|
BEFREE |
GSTP1 c.313A>G genotype was recently described as a predictor of vomiting related to high-dose cisplatin.
|
30870506 |
2019 |
|
Ulcerative Colitis
|
|
0.010 |
GeneticVariation
|
BEFREE |
XRCC1 Arg399Gln and GSTP1 Ile104Val polymorphisms may influence the CIHM status in the rectal mucosa of UC patients and may be substantially involved in UC-associated carcinogenesis.
|
21234761 |
2011 |
|
Tumor Progression
|
|
0.010 |
GeneticVariation
|
BEFREE |
The current data, based on a large cohort (n = 929) of Chinese patients with gastric cancer, suggested that the presence of SOD2 rs4880 and GSTP1 rs1695 genotypes may contribute to cancer progression as well as tumor aggressiveness.
|
22517484 |
2012 |
|
Thrombocytopenia
|
|
0.030 |
GeneticVariation
|
BEFREE |
<i>GSTP1</i> rs1695 showed the smallest p value for hematotoxicity association, and the <sup>105</sup>Ile wild type allele had a significantly higher risk of severe hematotoxicity (neutropenia G4, thrombocytopenia ≥ G3 and anemia ≥ G3) than the <sup>105</sup>Val allele (p=0.00034, odds ratio=5.71 (95% confidence interval:1.77-18.44)).
|
30038720 |
2018 |
|
Thrombocytopenia
|
|
0.030 |
GeneticVariation
|
BEFREE |
No significant association was found between DPYD*6, GSTP1 ile105val polymorphisms and CAPOX related toxicities except for thrombocytopenia.
|
31653159 |
2019 |
|
Thrombocytopenia
|
|
0.030 |
GeneticVariation
|
BEFREE |
The aim of the study is to evaluate the association between granulocytopenia and thrombocytopenia induced by platinum-based drugs and GSTP1 rs1695 gene polymorphism by meta-analysis.
|
30238837 |
2018 |
|
Testicular Germ Cell Tumor
|
|
0.010 |
GeneticVariation
|
BEFREE |
Germline deletion polymorphisms in the glutathione S-transferase mu 1 (GSTM1) and the GST theta 1 (GSTT1), and a functional single nucleotide polymorphism in GST pi 1 (GSTP1, Ile105Val), were analyzed in TGCT survivors (TCSs) (n = 675) and controls (n = 189).
|
19741569 |
2009 |
|
TARSAL-CARPAL COALITION SYNDROME
|
|
0.010 |
GeneticVariation
|
BEFREE |
This study indicated that GSTP1 gene 313 A/G (rs1695) polymorphism increased the susceptibility to BCa, particularly to TCC.
|
31454540 |
2019 |
|
Tardive Dyskinesia
|
|
0.010 |
GeneticVariation
|
BEFREE |
Association study between a functional glutathione S-transferase (GSTP1) gene polymorphism (Ile105Val) and tardive dyskinesia.
|
16039055 |
2005 |
|
Stomach Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
Meta-analysis of those 12 studies showed that there was an obvious association between GSTP1 Ile105Val polymorphism and gastric cancer risk in East Asians under three genetic models (for valine vs. isoleucine, OR=1.32, 95 %CI 1.05-1.66, P=0.015; for ValVal vs. IleIle, OR=2.00, 95 %CI 1.34-2.98, P=0.001; for the recessive model, OR=1.96, 95 %CI 1.35-2.83, P<0.001).
|
23456768 |
2013 |
|
Squamous cell carcinoma of the head and neck
|
|
0.050 |
GeneticVariation
|
BEFREE |
GSTM1, GSTT1 and GSTP1 Ile105Val polymorphisms in outcomes of head and neck squamous cell carcinoma patients treated with cisplatin chemoradiation.
|
31249357 |
2019 |
|
Squamous cell carcinoma of the head and neck
|
|
0.050 |
GeneticVariation
|
BEFREE |
We hypothesized that head and neck squamous cell carcinoma (HNSCC) might respond differently to chemotherapeutic agents, especially cisplatin (CDDP) because of the presence of GSTP1 I105V polymorphism.
|
15254763 |
2004 |
|
Squamous cell carcinoma of the head and neck
|
|
0.050 |
GeneticVariation
|
BEFREE |
We investigated the association between the occurrence of acute reactions in 101 patients with squamous cell carcinoma of the head and neck (SCCHN) after radiotherapy (RT) and five genetic polymorphisms: XRCC1 c.1196A>G, XRCC3 c.722C>T, RAD51 (c.-3429G>C, c.-3392G>T), and GSTP1 c.313A>G.
|
21704413 |
2011 |
|
Squamous cell carcinoma of the head and neck
|
|
0.050 |
GeneticVariation
|
BEFREE |
This large prospective cohort study supports a modestly increased risk of SPM after index SCCHN with GSTP1 Ile(105)Val polymorphism and an even greater risk of SPM with multiple combined GST risk genotypes.
|
19401526 |
2009 |
|
Squamous cell carcinoma of the head and neck
|
|
0.050 |
GeneticVariation
|
BEFREE |
ADH1B histidine allele (rs1229984), CYP2E1 rs3813867 heterozygous genotype, and GSTT1 deletion conferred protection against HNSCC (OR: 0.318 [0.04-0.75], OR: 0.13 [0.02-0.94], and OR: 0.12 [0.02-0.60], respectively) while GSTP1 (rs1695) Val/Val genotype was related to an increased risk (OR: 4.12 [1.11-15.31]).
|
25639971 |
2015 |
|
Squamous cell carcinoma of esophagus
|
|
0.030 |
GeneticVariation
|
BEFREE |
GSTP1 Ile105Val polymorphism was an independent risk factor (OR = 2.12, CI 1.37-3.29), whereas GSTT1 wild-type was an independent protective factor for ESCC (OR = 0.37, CI 0.16-0.79).
|
17916905 |
2007 |
|
Squamous cell carcinoma of esophagus
|
|
0.030 |
GeneticVariation
|
BEFREE |
Low or intermediate activity enzyme genotypes for GSTM1, GSTA1, GSTP1 I105V and A114V as well as for GSTT1, did not significantly modify the risk for ESCC or EAC in our Dutch population.
|
23731957 |
2013 |
|
Squamous cell carcinoma of esophagus
|
|
0.030 |
GeneticVariation
|
BEFREE |
Although there was no association between the GSTT1 deletion polymorphism or the GSTP1 Ile105Val polymorphism with OSCC, our results suggest that the presence of the recently described GSTT2B deletion may have a protective effect on the risk of OSCC in the Mixed Ancestry South African population.
|
22216261 |
2011 |