|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.100 |
GeneticVariation
|
BEFREE |
Obesity, Type II diabetes and the Ala54Thr polymorphism of fatty acid binding protein 2 in the Tongan population.
|
12855223 |
2003 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.100 |
GeneticVariation
|
BEFREE |
However, the large majority of studies assessing the potential association between the Ala54Thr FABP2 variant and insulin resistance/type 2 diabetes did not account for the independent and substantial effects of body composition, habitual physical activity (PA) levels, and diet on insulin resistance.
|
12209017 |
2002 |
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our data suggested that Ala54Thr polymorphism of the FABP2 gene is not a major contributing factor for obesity and obesity with dyslipidemia in Japanese children.
|
11866034 |
2001 |
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
A missense mutation (A54T) in the fatty acid binding protein type 2 (FABP2) gene has been associated with insulin resistance and obesity.
|
11707533 |
2001 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.100 |
GeneticVariation
|
BEFREE |
In conclusion, no major difference was associated with the beta3AR Trp64Arg or FABP2 Ala54Thr polymorphism in terms of type 2 diabetes or hyperlipidemia in young to older Japanese men.
|
11699048 |
2001 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.100 |
GeneticVariation
|
BEFREE |
(1) The Ala54 and Thr54 allele frequencies in Chinese were 0.71 and 0.29 respectively; (2) The FABP2-Ala54Thr variation was neither associated with fasting and post-challenged plasma glucose levels nor with NIDDM; (3) This variation was neither associated with fasting lipid profile nor with obesity; (4) The IGT subjects with genotype Thr54(+) (Thr54 homozygotes and heterozygotes) had lower fasting, 2-hour and total C-peptide levels and smaller AUC representing lesser C-peptide secretion after glucose challenge than those with genotype Thr54(-) (Ala54 homozygotes) (P = 0.04, 0.03, 0.01 and 0.01 respectively).
|
11593593 |
1999 |
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
(1) The Ala54 and Thr54 allele frequencies in Chinese were 0.71 and 0.29 respectively; (2) The FABP2-Ala54Thr variation was neither associated with fasting and post-challenged plasma glucose levels nor with NIDDM; (3) This variation was neither associated with fasting lipid profile nor with obesity; (4) The IGT subjects with genotype Thr54(+) (Thr54 homozygotes and heterozygotes) had lower fasting, 2-hour and total C-peptide levels and smaller AUC representing lesser C-peptide secretion after glucose challenge than those with genotype Thr54(-) (Ala54 homozygotes) (P = 0.04, 0.03, 0.01 and 0.01 respectively).
|
11593593 |
1999 |
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
An alanine to threonine substitution at codon 54 of the fatty acid binding protein 2 (FABP2) gene has been associated with insulin resistance in Pima Indians and with obesity in aboriginal Canadians.
|
10337870 |
1999 |
|
Metabolic Syndrome X
|
|
0.080 |
GeneticVariation
|
BEFREE |
The FABP2 Ala54Thr polymorphism was significantly associated with obesity (AT vs AA: OR = 2.633, 95%CI = 1.065-6.663, P = 0.036; TT vs AA: OR = 4.160, 95%CI = 1.609-10.757, P = 0.003) and metabolic syndrome (TT vs AA: OR = 2.273, 95%CI = 1.242-4.156, P = 0.008) by logistic regression with adjustment for covariates.
|
25730055 |
2015 |
|
Metabolic Syndrome X
|
|
0.080 |
GeneticVariation
|
BEFREE |
The aim of this study was to investigate the association between FABP2 Ala54Thr genetic polymorphism and metabolic syndrome and some biochemical and anthropological parameters in elderly subjects.
|
22838187 |
2012 |
|
Metabolic Syndrome X
|
|
0.080 |
GeneticVariation
|
BEFREE |
Metabolic syndrome and ALA54THR polymorphism of fatty acid-binding protein 2 in obese patients.
|
20723947 |
2011 |
|
Metabolic Syndrome X
|
|
0.080 |
GeneticVariation
|
BEFREE |
AGT T174M, GNB3 825C>T, and APOC3 -455T>C genotypes were significantly associated with MetS (P = 0.018, 0.0056, and 0.029, respectively) for female adults, whereas FABP2 A54T genotype was associated with MetS (P = 0.040) for female adolescents.
|
15869758 |
2006 |
|
Metabolic Syndrome X
|
|
0.080 |
GeneticVariation
|
BEFREE |
The odds ratio (adjusted for age and sex) for MS for the individuals carrying the Ala54Thr genotype was 1.240 (95% CI, 1.02-1.51; P = .03), whereas for those carrying the Thr54Thr genotype, it was 1.812 (95% CI, 1.28-2.57; P = .001).
|
16919542 |
2006 |
|
Metabolic Syndrome X
|
|
0.080 |
GeneticVariation
|
BEFREE |
The Ala54Thr polymorphism in the fatty acid-binding protein 2 (FABP2) gene as well as the T-455C and C-482T polymorphisms in the apolipoprotein C-III (APOC3) gene promoter have been associated with features of the MS in specific populations.
|
15598690 |
2005 |
|
Metabolic Syndrome X
|
|
0.080 |
GeneticVariation
|
BEFREE |
Our objectives were to determine whether Ala54Thr FABP2 and G-493T MTP polymorphisms are associated with increased risks of insulin resistance syndrome (IRS) in youth and/or modify the expression of accompanying dyslipidemia.
|
15547295 |
2005 |
|
Metabolic Syndrome X
|
|
0.080 |
GeneticVariation
|
BEFREE |
The Ala54Thr polymorphism of the FABP2 gene is not associated with CHD, markers of the metabolic syndrome, or the fatty acid profile of serum lipids in Finnish CHD patients.
|
12189904 |
2002 |
|
Dyslipidemias
|
|
0.050 |
GeneticVariation
|
BEFREE |
The alanine to threonine amino acid substitution at codon 54 (Ala54Thr) of the intestinal fatty acid binding protein (FABP2) has been associated with elevated levels of insulin and blood glucose as well as with dyslipidemia.
|
26703680 |
2015 |
|
Dyslipidemias
|
|
0.050 |
GeneticVariation
|
BEFREE |
The results from the published studies on the association of fatty acid-binding protein 2 (FABP2) Ala54Thr polymorphism with dyslipidemia are conflicting and inconclusive.
|
20047744 |
2010 |
|
Dyslipidemias
|
|
0.050 |
GeneticVariation
|
BEFREE |
Our objectives were to determine whether Ala54Thr FABP2 and G-493T MTP polymorphisms are associated with increased risks of insulin resistance syndrome (IRS) in youth and/or modify the expression of accompanying dyslipidemia.
|
15547295 |
2005 |
|
Dyslipidemias
|
|
0.050 |
GeneticVariation
|
BEFREE |
Our data suggested that Ala54Thr polymorphism of the FABP2 gene is not a major contributing factor for obesity and obesity with dyslipidemia in Japanese children.
|
11866034 |
2001 |
|
Dyslipidemias
|
|
0.050 |
GeneticVariation
|
BEFREE |
To investigate whether or not the intestinal fatty acid binding protein gene (FABP2)-Ala54Thr variation is related to non-insulin dependent diabetes mellitus (NIDDM), obesity, dyslipidemia and glucose stimulated insulin secretion (GSIS) in Chinese.
|
11593593 |
1999 |
|
Hypertriglyceridemia
|
|
0.030 |
GeneticVariation
|
BEFREE |
The Ala54Thr polymorphism of FABP2 was associated with high triglycerides levels, but not to GSD; suggesting that environmental factors modulate such susceptibility.
|
26019038 |
2016 |
|
Cardiovascular Diseases
|
|
0.030 |
GeneticVariation
|
BEFREE |
Therefore, we aimed to test the hypotheses that in MDD-patients the FABP2 Ala54Thr-polymorphism would be (I) more prevalent than in sex- and age-matched controls, (II) associated with observed alterations in FA-metabolism, and (III) associated with CVD-risk factor waist circumference.
|
24340071 |
2013 |
|
Diabetes Mellitus
|
|
0.030 |
GeneticVariation
|
BEFREE |
The Ala54Thr polymorphism of FABP2 gene increases affinity of intestinal fatty acid-binding protein 2 for long-chain dietary fatty acids (FA) in subjects without diabetes.
|
20484485 |
2010 |
|
Diabetes
|
|
0.030 |
GeneticVariation
|
BEFREE |
The Ala54Thr polymorphism of FABP2 gene increases affinity of intestinal fatty acid-binding protein 2 for long-chain dietary fatty acids (FA) in subjects without diabetes.
|
20484485 |
2010 |