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Metabolic Syndrome X
|
|
0.100 |
GeneticVariation
|
BEFREE |
Combined effects of the C161T and Pro12Ala PPARγ2 gene variants with insulin resistance on metabolic syndrome: a case-control study of a central Tunisian population.
|
24243083 |
2014 |
|
Metabolic Syndrome X
|
|
0.100 |
GeneticVariation
|
BEFREE |
In the group of participants with PPARγ Pro12Ala or Ala12Ala genotypes, those with the LPL Pvu (-/+) or (+/+) genotype had greater odds for MetSy (odds ratio OR=5.98; 95% confidence interval CI: 1.46-24.47, p=0.013).
|
24200052 |
2014 |
|
Diabetes Mellitus
|
|
0.100 |
GeneticVariation
|
BEFREE |
Proliferator-activated receptor gamma Pro12Ala interacts with the insulin receptor substrate 1 Gly972Arg and increase the risk of insulin resistance and diabetes in the mixed ancestry population from South Africa.
|
24447396 |
2014 |
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
Interaction between Pro12Ala polymorphism of PPARγ2 and diet on adiposity phenotypes.
|
25342491 |
2014 |
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
The single nucleotide polymorphisms (SNPs) of the above genes, such as GNB3-C825T, ADRB3-Trp64Arg, UCP2-3'UTR 45 bp del/ins, and PPARγ-Pro12Ala, are associated with obesity and body mass index.
|
24827746 |
2014 |
|
Metabolic Syndrome X
|
|
0.100 |
GeneticVariation
|
BEFREE |
This study suggests that the PPARγ C1431T polymorphism is related to an increased risk of MetS in an Iranian population and interacts with the Pro12Ala polymorphism, further increasing the risk of MetS.
|
24464185 |
2014 |
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
In the group with ACE DD genotype, those with PPARγ Pro12Ala or Ala12Ala genotype have greater odds for obesity (OR=9.98; 95% CI: 1.18-84.14, p=0.034).
|
24200052 |
2014 |
|
Diabetes
|
|
0.100 |
GeneticVariation
|
BEFREE |
Proliferator-activated receptor gamma Pro12Ala interacts with the insulin receptor substrate 1 Gly972Arg and increase the risk of insulin resistance and diabetes in the mixed ancestry population from South Africa.
|
24447396 |
2014 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.100 |
GeneticVariation
|
BEFREE |
Hence, our aim was to develop a low-cost method for the validation of PPARG (Pro12Ala, CCA>GCA) SNP (rs1801282) for its association with T2D.
|
25063576 |
2014 |
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
Concurrently, genotyping of the Pro12Ala polymorphism showed that obese subjects possess a significantly higher frequency of the Pro/Pro genotype than nonobese controls (90.5 vs 79.5%; P = 0.03), suggesting that this genotype is involved in an increased risk of obesity in the Tunisian population.
|
23315125 |
2013 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.100 |
GeneticVariation
|
BEFREE |
The association between PPARG Pro12Ala SNP and increased T2D susceptibility was confirmed, with Pro12 as risk allele.
|
23386649 |
2013 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.100 |
GeneticVariation
|
BEFREE |
Meanwhile PPARG-2 Pro12Ala, CDKN2A/2B rs10811661, IGF2BP2 rs4402960, HHEX rs7923837, CDKAL1 rs7754840, EXT2 rs1113132 and SLC30A8 rs13266634 were found to have no significant association with T2D among Arabs.
|
23458876 |
2013 |
|
Coronary Artery Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
We investigated the relationship of the Pro 12 Ala PPARγ2 polymorphism with the presence and severity of coronary artery disease (CAD) assessed by Gensini score (Gs).
|
23652363 |
2013 |
|
Polycystic Ovary Syndrome
|
|
0.100 |
GeneticVariation
|
BEFREE |
Pro12Ala polymorphism of PPARγ showed significant association with decreased PCOS susceptibility.
|
23748472 |
2013 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.100 |
GeneticVariation
|
BEFREE |
A total of 180 subjects with DR, 193 subjects with type 2 diabetes mellitus (T2DM) with no diabetic retinopathy, and 200 healthy normoglycemic non-retinopathic Pakistani individuals were genotyped for the rs1801282 (c.34C>G) polymorphism using polymerase chain reaction-restriction fragment length polymorphism.
|
23559865 |
2013 |
|
Polycystic Ovary Syndrome
|
|
0.100 |
GeneticVariation
|
BEFREE |
Pro12Ala PPAR γ2 gene polymorphism in PCOS women: the role of compounds regulating satiety.
|
21827375 |
2012 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.100 |
GeneticVariation
|
BEFREE |
Pro12Ala mutation decreases PPARG activity and resistance to NIDDM.
|
22937051 |
2012 |
|
Coronary Artery Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our results demonstrated that the PPARγ2 Pro12Ala polymorphism might be risk-conferring locus for the progression of CAD among Caucasians, but not among Asians.
|
23300871 |
2012 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.100 |
GeneticVariation
|
BEFREE |
In the case-control analysis, PPARG rs1801282 (Pro12Ala) (OR=1.48 (1.02-2.16)), ADIPOQ rs1063539 (OR=1.17 (1.01-1.35)), and HNF4A rs1884614 (OR=1.16 (1.00-1.32) were associated with T2D (P(allelic)<0.05).
|
22515931 |
2012 |
|
Diabetes Mellitus
|
|
0.100 |
GeneticVariation
|
BEFREE |
The interaction of the PPARγ Pro12Ala polymorphism with diabetes and cardiovascular risk is controversial.
|
22017455 |
2012 |
|
Polycystic Ovary Syndrome
|
|
0.100 |
GeneticVariation
|
BEFREE |
Ultimately, sensitivity analysis demonstrated that, in total, there was no significant association between Pro12Ala polymorphism and PCO</span>S in the contrast of G allele versus C allele OR = 0.84 (95 % CI 0.69-1.04) and in Europeans, no significant association in the comparison of G allele versus C allele (OR = 0.84, 95 % CI 0.67-1.06) was also indicated.
|
22729915 |
2012 |
|
Coronary Artery Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
The results of the present study demonstrated that possessing the A allele of RAGE -374T/A polymorphism by diabetic CAD patients and possessing the-374T/Ala12 haplotype of RAGE -374T/A and PPAR-γ Pro12 Ala polymorphisms by the patients group were the most important risk factors for CAD.
|
21861709 |
2012 |
|
Metabolic Syndrome X
|
|
0.100 |
GeneticVariation
|
BEFREE |
The frequency distribution of rare alleles for PPARα (L162V) and PPARγ (P12A and H449H) was compared using the chi square test in 363 HIV-1-infected patients classified according to the presence or absence of the metabolic syndrome after 48 months of follow-up on their first PI-containing regimen.
|
21877956 |
2012 |
|
Polycystic Ovary Syndrome
|
|
0.100 |
GeneticVariation
|
BEFREE |
Pro12Ala polymorphism was significantly associated with the susceptibility of PCOS (odds ratio [OR] 0.74, 95 % confidence interval [CI] [0.61, 0.90] for allele; OR 0.70, 95 % CI [0.57, 0.86] for genotype).
|
22527903 |
2012 |
|
Diabetes Mellitus
|
|
0.100 |
GeneticVariation
|
BEFREE |
Effect of the PPARG2 Pro12Ala polymorphism and clinical risk factors for diabetes mellitus on HbA1c in the Japanese general population.
|
23006958 |
2012 |