Age related macular degeneration
|
|
0.060 |
GeneticVariation
|
BEFREE |
We tested for an association between the functional toll-like receptor 3 gene (TLR3) variant rs3775291 (involving the substitution of phenylalanine for leucine at amino acid 412) and age-related macular degeneration in Americans of European descent.
|
18753640 |
2008 |
Age related macular degeneration
|
|
0.060 |
GeneticVariation
|
BEFREE |
Coding SNPs in TLR3 (rs3775291) and TLR7 (rs179008) showed association with AMD in one group (P = 0.01 and P = 0.02, respectively) before correction for multiple testing.
|
18385087 |
2008 |
Geographic Atrophy
|
|
0.030 |
GeneticVariation
|
BEFREE |
The Phe variant (encoded by the T allele at rs3775291) was associated with protection against geographic atrophy (P=0.005).
|
18753640 |
2008 |
Subacute Sclerosing Panencephalitis
|
|
0.010 |
GeneticVariation
|
BEFREE |
The frequency of 412Phe allele of TLR3 rs3775291 in SSPE patients was significantly higher than that in controls (P=.03).
|
19016379 |
2008 |
Hepatitis C
|
|
0.070 |
GeneticVariation
|
BEFREE |
This study analyzed epidemiological and clinical data from a total of 137 patients with chronic HCV infection with regard to two polymorphic positions within the TLR3 gene: rs5743305 (T/A) is located within the promoter region and might affect transcriptional activity, rs3775291 (C/T) is a non-synonymous single nucleotide polymorphism (SNP) located within exon 4 and the variant receptor has been shown to be functionally impaired.
|
19475618 |
2009 |
Age related macular degeneration
|
|
0.060 |
GeneticVariation
|
BEFREE |
Even with previously verified samples sets and adequate study powers, the results did not confirm the reported associations of TLR3 rs3775291 and TLR4 rs4986790 with AMD in the three independent samples, individually or combined.
|
19628747 |
2009 |
Age related macular degeneration
|
|
0.060 |
GeneticVariation
|
BEFREE |
A single-nucleotide polymorphism (SNP; rs3775291) in the Toll-like receptor 3 (TLR3) gene has recently been implicated in the pathogenesis of AMD in Caucasian populations.
|
21079408 |
2011 |
Geographic Atrophy
|
|
0.030 |
GeneticVariation
|
BEFREE |
Toll-like receptor 3 C1234T may protect against geographic atrophy through decreased dsRNA binding capacity.
|
21712495 |
2011 |
Polypoidal choroidal vasculopathy
|
|
0.010 |
GeneticVariation
|
BEFREE |
This study indicates that the TLR3 rs3775291 gene polymorphism is not associated with CNV and PCV in Singaporean Chinese patients.
|
21079408 |
2011 |
Colorectal Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
More importantly, among 582 followed up patients the SNP rs3775291 in the toll-like receptor 3 (TLR-3) gene was associated with CRC specific survival (150 events).
|
21239167 |
2011 |
Hepatitis C
|
|
0.070 |
GeneticVariation
|
BEFREE |
We genotyped rs3775291 in a population of Spanish HIV-1-exposed seronegative (HESN) individuals who remain HIV seronegative despite repeated exposure through i.v. injection drug use (IDU-HESN individuals) as witnessed by their hepatitis C virus seropositivity.
|
22174453 |
2012 |
Wheezing
|
|
0.010 |
GeneticVariation
|
BEFREE |
Preliminary evidence was found that TLR3 L412F gene polymorphism may be associated with bronchiolitis leading to hospitalization and postbronchiolitis wheezing.
|
22549436 |
2012 |
Herpes Labialis
|
|
0.010 |
GeneticVariation
|
BEFREE |
Furthermore, the TLR3 L412F genetic polymorphism was found to reduce NK cell TLR3-responsiveness and is associated with susceptibility to recurrent HL.
|
22537752 |
2012 |
Non-Small Cell Lung Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
Among the 178 SNPs, 24 were significantly associated with NSCLC prognosis in different genetic models and four of them were remained in the final predictive model after multivariate stepwise Cox regression, including IL-5R rs11713419 (5'-untranslated region, 5'-UTR) (P = 0.001), IL23R rs6682925 (5'-flanking region, 5'-FR) (P = 0.017), TLR1 rs5743551 (5'-FR) (P = 0.02) and TLR3 rs3775291 (Leu412Phe) (P = 0.01).
|
21412764 |
2012 |
Bacterial Infections
|
|
0.010 |
GeneticVariation
|
BEFREE |
Recently we have shown an association of a TLR3 receptor variant, L412F, to susceptibility to chronic candidiasis, recurrent viral and bacterial infections and autoimmunity.
|
22024499 |
2012 |
Virus Diseases
|
|
0.010 |
GeneticVariation
|
BEFREE |
Genetic association studies have provided evidence concerning the role of a polymorphism in TLR3 (rs3775291, Leu412Phe) in viral infection susceptibility.
|
22174453 |
2012 |
Cutaneous Candidiasis
|
|
0.010 |
GeneticVariation
|
BEFREE |
The biological significance of TLR3 variant, L412F, in conferring susceptibility to cutaneous candidiasis, CMV and autoimmunity.
|
22024499 |
2012 |
Drug usage
|
|
0.010 |
GeneticVariation
|
BEFREE |
We genotyped rs3775291 in a population of Spanish HIV-1-exposed seronegative (HESN) individuals who remain HIV seronegative despite repeated exposure through i.v. injection drug use (IDU-HESN individuals) as witnessed by their hepatitis C virus seropositivity.
|
22174453 |
2012 |
Bronchiolitis
|
|
0.010 |
GeneticVariation
|
BEFREE |
Preliminary evidence was found that TLR3 L412F gene polymorphism may be associated with bronchiolitis leading to hospitalization and postbronchiolitis wheezing.
|
22549436 |
2012 |
Autoimmune Diseases
|
|
0.010 |
GeneticVariation
|
BEFREE |
We have shown here aberrant biological responses mediated by the TLR3 variant receptor, L412F, which may explain in part susceptibility of patients to chronic candidiasis, viral infections and autoimmunity.
|
22024499 |
2012 |
Chronic candidiasis
|
|
0.010 |
GeneticVariation
|
BEFREE |
We have shown here aberrant biological responses mediated by the TLR3 variant receptor, L412F, which may explain in part susceptibility of patients to chronic candidiasis, viral infections and autoimmunity.
|
22024499 |
2012 |
Recurrent herpes simplex labialis
|
|
0.010 |
GeneticVariation
|
BEFREE |
Association of TLR3-hyporesponsiveness and functional TLR3 L412F polymorphism with recurrent herpes labialis.
|
22537752 |
2012 |
Hepatitis C
|
|
0.070 |
GeneticVariation
|
BEFREE |
TLR3 L412F is significantly common in HCV-infected liver recipients, and may be associated with worse outcomes.
|
23240626 |
2013 |
Tick-Borne Encephalitis
|
|
0.020 |
GeneticVariation
|
BEFREE |
These results indicate that the G allele (within the G/G homozygous genotype) of the TLR3 rs3775291 SNP is associated with predisposition to TBE in the Russian population.
|
23721942 |
2013 |
Hepatitis B, Chronic
|
|
0.020 |
GeneticVariation
|
BEFREE |
Two polymorphisms in the TLR3 gene, A952T and C1234T, were tested by direct sequencing in 452 chronic hepatitis B (CHB) patients and 462 healthy controls.
|
23076446 |
2013 |