|
Alzheimer's Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
rs3851179 and rs541458 appear to be associated with decreased AD risk.
|
31385771 |
2019 |
|
Alzheimer's Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
(2) Four additional AD risk SNPs were nominally associated with obesity (rs17125944 at FERMT2, pBMI = 4.03 × 10(-05), pBMI corr = 2.50 × 10(-03) ; rs3851179 at PICALM; pBMI = 0.002, rs2075650 at TOMM40/APOE, pBMI = 0.024, rs3865444 at CD33, pBMI = 0.024).
|
24788522 |
2014 |
|
Alzheimer's Disease
|
|
0.900 |
GeneticVariation
|
GWASCAT |
These associations were replicated in stage 2 (2,023 cases and 2,340 controls), producing compelling evidence for association with Alzheimer's disease in the combined dataset (rs11136000, P = 8.5 x 10(-10), odds ratio = 0.86; rs3851179, P = 1.3 x 10(-9), odds ratio = 0.86).
|
19734902 |
2009 |
|
Alzheimer's Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
We failed to replicate this association between the rs3851179 polymorphism and AD in all samples and the APOEε4-negative subgroup.
|
23040034 |
2013 |
|
Alzheimer's Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
There was no association observed with AD at both rs11136000 CLU (p=0.25) and rs3851179 PICALM (p=0.54).
|
28558900 |
2017 |
|
Alzheimer's Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
Phosphatidylinositol-binding clathrin assembly protein (PICALM) (rs3851179) has been associated with AD; in particular, the A allele may serve a protective role, while the G allele serves as a strong genetic risk factor.
|
28549650 |
2017 |
|
Alzheimer's Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
Gene-brain structure associations of 3 recently discovered risk genes for Alzheimer's disease, CLU (rs11136000C>T), CR1 (rs6656401G>A), and PICALM (rs3851179G>A), were investigated in 2 independent cohorts of young healthy adults (n = 430 and n = 492, respectively).
|
21726919 |
2011 |
|
Alzheimer's Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
We detected a significant association of the MTHFR rs1801133 and PICALM rs3851179 polymorphisms with AD.
|
25359311 |
2015 |
|
Alzheimer's Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
A recent genome-wide study (GWAS) identified a single nucleotide polymorphism (SNP) rs3851179 in the 5' to the PICALM gene strongly associated with Alzheimer's disease (AD) in Caucasians.
|
20951388 |
2011 |
|
Autoantibody measurement
|
|
0.700 |
GeneticVariation
|
GWASDB |
Genetic variant near IRS1 is associated with type 2 diabetes, insulin resistance and hyperinsulinemia.
|
19734900 |
2009 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.010 |
GeneticVariation
|
BEFREE |
The aim of this study was to examine whether the variants of some candidate genes involved in the development of AD, namely BIN1 (rs744373), CLU (rs11136000), CR1 (rs3818361), and PICALM (rs3851179), are related to several disorders of glucose metabolism-gestational diabetes (GDM), T2DM and impaired glucose tolerance (IGT).
|
28316001 |
2017 |
|
Familial lichen amyloidosis
|
|
0.010 |
GeneticVariation
|
BEFREE |
63) associated nominally significantly with posterior AD, and rs3851179 at the PICALM locus had significant association with PCA (p = 0.0003, OR = 2.84).
|
24670887 |
2014 |
|
Gestational Diabetes
|
|
0.010 |
GeneticVariation
|
BEFREE |
This study demonstrates an association between PICALM rs3851179 and GDM as well as IGT.
|
28316001 |
2017 |
|
Impaired cognition
|
|
0.010 |
GeneticVariation
|
BEFREE |
Our finding suggests that PICALM rs3851179 could contribute to cognitive impairment in older patients with PD.
|
26889634 |
2016 |
|
Impaired glucose tolerance
|
|
0.010 |
GeneticVariation
|
BEFREE |
This study demonstrates an association between PICALM rs3851179 and GDM as well as IGT.
|
28316001 |
2017 |
|
Memory impairment
|
|
0.010 |
GeneticVariation
|
BEFREE |
There was an effect of the APOE-PICALM (rs3851179) interactions on reduced CMRgl in regions of vDMN (P < .001), and on memory deficits (F<sub>3,93</sub> =5.568, P = .020).
|
29883038 |
2019 |
|
Mild cognitive disorder
|
|
0.020 |
GeneticVariation
|
BEFREE |
The PICALM rs3851179 polymorphism significantly affects the DMN network in MCI.
|
28549650 |
2017 |
|
Mild cognitive disorder
|
|
0.020 |
GeneticVariation
|
BEFREE |
PICALM-rs3851179-G had an unexpected protective effect on incident MCI/LOAD.
|
25189118 |
2015 |
|
Obesity
|
|
0.010 |
GeneticVariation
|
BEFREE |
(2) Four additional AD risk SNPs were nominally associated with obesity (rs17125944 at FERMT2, pBMI = 4.03 × 10(-05), pBMI corr = 2.50 × 10(-03) ; rs3851179 at PICALM; pBMI = 0.002, rs2075650 at TOMM40/APOE, pBMI = 0.024, rs3865444 at CD33, pBMI = 0.024).
|
24788522 |
2014 |
|
Parkinson Disease
|
|
0.030 |
GeneticVariation
|
BEFREE |
Our results do not provide evidence that the PICALM rs3851179 polymorphism increase susc</span>eptibility of PD, in the Greek population.
|
22715855 |
2012 |
|
Parkinson Disease
|
|
0.030 |
GeneticVariation
|
BEFREE |
The two other SNPs, rs6656401 from CR1, and rs3851179 from PICALM region were not associated with PD (p>0.05).
|
21912625 |
2011 |
|
Parkinson Disease
|
|
0.030 |
GeneticVariation
|
BEFREE |
Our finding suggests that PICALM rs3851179 could contribute to cognitive impairment in older patients with PD.
|
26889634 |
2016 |
|
PARKINSON DISEASE, LATE-ONSET
|
|
0.010 |
GeneticVariation
|
BEFREE |
More genetic studies using large-sized and well-defined matched samples of AD and PD patients from mixed populations as well as functional correlation analysis are urgently needed to clarify the role of rs3851179 in the AD/PD risk.
|
28567584 |
2017 |
|
Prion Diseases
|
|
0.700 |
GeneticVariation
|
GWASDB |
Genome-wide association study in multiple human prion diseases suggests genetic risk factors additional to PRNP.
|
22210626 |
2012 |
|
Schizophrenia
|
|
0.010 |
GeneticVariation
|
BEFREE |
Polymorphisms rs11136000 and rs3851179 were analyzed among 184 Chinese patients with schizophrenia and 162 healthy controls.
|
20738160 |
2010 |