|
Coronary heart disease
|
|
0.820 |
GeneticVariation
|
BEFREE |
SNPs rs6700896 in LEPR (OR, 1.06; 95% CI, 1.02 to 1.09; per minor allele), rs4537545 in IL6R (OR, 0.94; 95% CI, 0.91 to 0.97), and rs4420638 in the APOE-CI-CII cluster (OR, 1.16; 95% CI, 1.12 to 1.21) were all associated with risk of coronary heart disease.
|
19567438 |
2009 |
|
Alzheimer's Disease
|
|
0.820 |
GeneticVariation
|
BEFREE |
The SNPs rs2075650 and rs4420638 were linked to the most replications within a single reclassified phenotype or very similar reclassified phenotypes; both were associated with Alzheimer's disease (AD).
|
29942042 |
2019 |
|
Alzheimer's Disease
|
|
0.820 |
GeneticVariation
|
BEFREE |
The minor allele of rs4420638 (G) and the minor allele of rs157582 (T) showed associations with lower Mini-mental State Examination score, higher Alzheimer Disease Assessment Scale-cognitive subscale 11 score and smaller entorhinal volume using both baseline and longitudinal measurements, as well as with accelerated cognitive decline.
|
31760383 |
2019 |
|
Coronary heart disease
|
|
0.820 |
GeneticVariation
|
BEFREE |
Our case-control study shows that rs4420638 genotype AA has a significant association with the concentrations of circulating HDL-C and APOA-I in CHD in Han Chinese males.
|
26535656 |
2015 |
|
Age related macular degeneration
|
|
0.810 |
GeneticVariation
|
BEFREE |
Nineteen single nucleotide polymorphisms (SNPs) previously associated with AMD, including rs10490924 (<i>ARMS2/HTRA1</i>), rs10737680 (<i>CFH</i>), rs13278062 (<i>TNFRSF10A</i>), rs1864163 (<i>CETP</i>), rs2230199 (<i>C3</i>), rs3130783 (<i>IER3/DDR1</i>), rs334353 (<i>TGFBR1</i>), rs3812111 (<i>COL10A1</i>), rs429608 (<i>C2/CFB</i>), rs4420638 (<i>APOE</i>), rs4698775 (<i>CFI</i>), rs5749482 (<i>TIMP3</i>), rs6795735 (<i>ADAMTS9</i>), rs8017304 (<i>RAD51B</i>), rs8135665 (<i>SLC16A8</i>), rs920915 (<i>LIPC</i>), rs943080 (<i>VEGFA</i>), rs9542236 (<i>B3GALTL</i>) and rs13081855 (<i>COL8A1/FILIP1L</i>), were genotyped in this cohort.
|
31819893 |
2019 |
|
Coronary Artery Disease
|
|
0.720 |
GeneticVariation
|
BEFREE |
SNPs rs6700896 in LEPR (OR, 1.06; 95% CI, 1.02 to 1.09; per minor allele), rs4537545 in IL6R (OR, 0.94; 95% CI, 0.91 to 0.97), and rs4420638 in the APOE-CI-CII cluster (OR, 1.16; 95% CI, 1.12 to 1.21) were all associated with risk of coronary heart disease.
|
19567438 |
2009 |
|
Coronary Artery Disease
|
|
0.720 |
GeneticVariation
|
BEFREE |
Significant interaction of APOE rs4420638 polymorphism with HDL-C and APOA-I levels in coronary heart disease in Han Chinese men.
|
26535656 |
2015 |
|
Diabetes Mellitus
|
|
0.710 |
GeneticVariation
|
BEFREE |
Following regression analysis adjusted by collection center, gender, duration of diabetes, and average HbA1c, two SNPs were significantly associated with DN. rs4420638 in the APOC1 region (odds ratio [OR] = 1.51; confidence intervals [CI]: 1.19-1.91; P = 0.001) and rs1532624 in CETP (OR = 0.82; CI: 0.69-0.99; P = 0.034); rs4420638 was also significantly associated in a sensitivity analysis (P = 0.016) together with rs7679 (P = 0.027).
|
23555584 |
2013 |
|
Mental deterioration
|
|
0.710 |
GeneticVariation
|
BEFREE |
The minor allele of rs4420638 (G) and the minor allele of rs157582 (T) showed associations with lower Mini-mental State Examination score, higher Alzheimer Disease Assessment Scale-cognitive subscale 11 score and smaller entorhinal volume using both baseline and longitudinal measurements, as well as with accelerated cognitive decline.
|
31760383 |
2019 |
|
Diabetes
|
|
0.710 |
GeneticVariation
|
BEFREE |
Following regression analysis adjusted by collection center, gender, duration of diabetes, and average HbA1c, two SNPs were significantly associated with DN. rs4420638 in the APOC1 region (odds ratio [OR] = 1.51; confidence intervals [CI]: 1.19-1.91; P = 0.001) and rs1532624 in CETP (OR = 0.82; CI: 0.69-0.99; P = 0.034); rs4420638 was also significantly associated in a sensitivity analysis (P = 0.016) together with rs7679 (P = 0.027).
|
23555584 |
2013 |
|
Coronary Arteriosclerosis
|
|
0.020 |
GeneticVariation
|
BEFREE |
Significant interaction of APOE rs4420638 polymorphism with HDL-C and APOA-I levels in coronary heart disease in Han Chinese men.
|
26535656 |
2015 |
|
Coronary Arteriosclerosis
|
|
0.020 |
GeneticVariation
|
BEFREE |
SNPs rs6700896 in LEPR (OR, 1.06; 95% CI, 1.02 to 1.09; per minor allele), rs4537545 in IL6R (OR, 0.94; 95% CI, 0.91 to 0.97), and rs4420638 in the APOE-CI-CII cluster (OR, 1.16; 95% CI, 1.12 to 1.21) were all associated with risk of coronary heart disease.
|
19567438 |
2009 |
|
Impaired cognition
|
|
0.010 |
GeneticVariation
|
BEFREE |
The minor allele of rs4420638 (G) and the minor allele of rs157582 (T) showed associations with lower Mini-mental State Examination score, higher Alzheimer Disease Assessment Scale-cognitive subscale 11 score and smaller entorhinal volume using both baseline and longitudinal measurements, as well as with accelerated cognitive decline.
|
31760383 |
2019 |
|
Diabetic Nephropathy
|
|
0.010 |
GeneticVariation
|
BEFREE |
Following regression analysis adjusted by collection center, gender, duration of diabetes, and average HbA1c, two SNPs were significantly associated with DN. rs4420638 in the APOC1 region (odds ratio [OR] = 1.51; confidence intervals [CI]: 1.19-1.91; P = 0.001) and rs1532624 in CETP (OR = 0.82; CI: 0.69-0.99; P = 0.034); rs4420638 was also significantly associated in a sensitivity analysis (P = 0.016) together with rs7679 (P = 0.027).
|
23555584 |
2013 |
|
Polycystic Ovary Syndrome
|
|
0.010 |
GeneticVariation
|
BEFREE |
However, the rs4420638 G allele was related to increased serum luteinizing hormone, cholesterol and apoB levels, and the ratio of apoB to apoA1 (P < 0.05), and the -317H1H1 genotype was associated with a higher acne grade score and a higher ratio of apoB-PAF-AH to H-PAF-AH activity (P < 0.05) in patients with PCOS.
|
29636060 |
2018 |
|
Polycystic Ovary Syndrome
|
|
0.010 |
GeneticVariation
|
BEFREE |
The apoC1 rs4420638A/G and -317H1/H2 gene variants might be involved in endocrine abnormalities of reproductive axis, metabolic abnormalities and chronic inflammation in PCOS, although no association was observed between the apoC1 genetic variants and the risk of PCOS in Chinese women.
|
29636060 |
2018 |
|
Rheumatoid Arthritis
|
|
0.010 |
GeneticVariation
|
BEFREE |
Among them, 2 SNP, rs688 and rs4420638, were more prevalent in patients with RA than in controls.
|
23588940 |
2013 |
|
Obesity
|
|
0.010 |
GeneticVariation
|
BEFREE |
In genetic association studies adjusted for age, BMI SDS and sex, we identified significant associations for rs599839 near SORT1 with TC and LDL-C and for rs4420638 near APOE with TC and LDL-C. We performed Bayesian modelling of the combined lipid phenotype of HDL-C, LDL-C and TG to identify potentially causal polygenic effects on this multi-dimensional phenotype and considering obesity, age and sex as a-priori modulating factors.
|
26375028 |
2015 |
|
Alzheimer Disease, Late Onset
|
|
0.010 |
GeneticVariation
|
BEFREE |
SNP rs4420638 on chromosome 19, located 14 kilobase pairs distal to the APOE epsilon variant, significantly distinguished between AD cases and controls (Bonferroni corrected p value = 5.30 x 10(-34), OR = 4.01) and was far more strongly associated with the risk of AD than any other SNP of the 502,627 tested.
|
17474819 |
2007 |
|
Alzheimer's Disease
|
|
0.820 |
GeneticVariation
|
GWASCAT |
Genome-wide association analysis of age-at-onset in Alzheimer's disease.
|
22005931 |
2012 |
|
Alzheimer's Disease
|
|
0.820 |
GeneticVariation
|
GWASCAT |
A high-density whole-genome association study reveals that APOE is the major susceptibility gene for sporadic late-onset Alzheimer's disease.
|
17474819 |
2007 |
|
Alzheimer's Disease
|
|
0.820 |
GeneticVariation
|
GWASCAT |
Sorl1 as an Alzheimer's disease predisposition gene?
|
17975299 |
2008 |
|
Coronary heart disease
|
|
0.820 |
GeneticVariation
|
GWASCAT |
Pleiotropic Meta-Analyses of Longitudinal Studies Discover Novel Genetic Variants Associated with Age-Related Diseases.
|
27790247 |
2016 |
|
Alzheimer's Disease
|
|
0.820 |
GeneticVariation
|
GWASCAT |
Genome-wide analysis of genetic predisposition to Alzheimer's disease and related sex disparities.
|
30636644 |
2019 |
|
Alzheimer's Disease
|
|
0.820 |
GeneticVariation
|
GWASCAT |
Genome-wide association study of Alzheimer's disease.
|
22832961 |
2012 |