Parkinson Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
A common amino-acid polymorphism in COMT, valine-108-methionine, results in a low activity form of the enzyme which we hypothesised may influence susceptibility to IPD.
|
8941353 |
1996 |
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
It exists as common high and low activity alleles in the population (determined by a valine 158 methionine polymorphisms), and high red blood cell activity of COMT has previously been associated with schizophrenia.
|
9323320 |
1997 |
Nonorganic psychosis
|
|
0.100 |
GeneticVariation
|
BEFREE |
Because of its role in catecholamine metabolism and several lines of evidence pointing to a locus for psychosis near the COMT gene on chromosome 22q11, we have analysed the COMT Val158Met polymorphism as a candidate susceptibility factor for bipolar affective disorder.
|
9352569 |
1997 |
Bipolar Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
Because of its role in catecholamine metabolism and several lines of evidence pointing to a locus for psychosis near the COMT gene on chromosome 22q11, we have analysed the COMT Val158Met polymorphism as a candidate susceptibility factor for bipolar affective disorder.
|
9352569 |
1997 |
Psychotic Disorders
|
|
0.100 |
GeneticVariation
|
BEFREE |
Because of its role in catecholamine metabolism and several lines of evidence pointing to a locus for psychosis near the COMT gene on chromosome 22q11, we have analysed the COMT Val158Met polymorphism as a candidate susceptibility factor for bipolar affective disorder.
|
9352569 |
1997 |
MAJOR AFFECTIVE DISORDER 8
|
|
0.010 |
GeneticVariation
|
BEFREE |
Because of its role in catecholamine metabolism and several lines of evidence pointing to a locus for psychosis near the COMT gene on chromosome 22q11, we have analysed the COMT Val158Met polymorphism as a candidate susceptibility factor for bipolar affective disorder.
|
9352569 |
1997 |
MAJOR AFFECTIVE DISORDER 4
|
|
0.010 |
GeneticVariation
|
BEFREE |
Because of its role in catecholamine metabolism and several lines of evidence pointing to a locus for psychosis near the COMT gene on chromosome 22q11, we have analysed the COMT Val158Met polymorphism as a candidate susceptibility factor for bipolar affective disorder.
|
9352569 |
1997 |
MAJOR AFFECTIVE DISORDER 1
|
|
0.010 |
GeneticVariation
|
BEFREE |
Because of its role in catecholamine metabolism and several lines of evidence pointing to a locus for psychosis near the COMT gene on chromosome 22q11, we have analysed the COMT Val158Met polymorphism as a candidate susceptibility factor for bipolar affective disorder.
|
9352569 |
1997 |
MAJOR AFFECTIVE DISORDER 6
|
|
0.010 |
GeneticVariation
|
BEFREE |
Because of its role in catecholamine metabolism and several lines of evidence pointing to a locus for psychosis near the COMT gene on chromosome 22q11, we have analysed the COMT Val158Met polymorphism as a candidate susceptibility factor for bipolar affective disorder.
|
9352569 |
1997 |
MAJOR AFFECTIVE DISORDER 9
|
|
0.010 |
GeneticVariation
|
BEFREE |
Because of its role in catecholamine metabolism and several lines of evidence pointing to a locus for psychosis near the COMT gene on chromosome 22q11, we have analysed the COMT Val158Met polymorphism as a candidate susceptibility factor for bipolar affective disorder.
|
9352569 |
1997 |
MAJOR AFFECTIVE DISORDER 7
|
|
0.010 |
GeneticVariation
|
BEFREE |
Because of its role in catecholamine metabolism and several lines of evidence pointing to a locus for psychosis near the COMT gene on chromosome 22q11, we have analysed the COMT Val158Met polymorphism as a candidate susceptibility factor for bipolar affective disorder.
|
9352569 |
1997 |
MAJOR AFFECTIVE DISORDER 2
|
|
0.010 |
GeneticVariation
|
BEFREE |
Because of its role in catecholamine metabolism and several lines of evidence pointing to a locus for psychosis near the COMT gene on chromosome 22q11, we have analysed the COMT Val158Met polymorphism as a candidate susceptibility factor for bipolar affective disorder.
|
9352569 |
1997 |
Obsessive-Compulsive Disorder
|
|
0.090 |
GeneticVariation
|
BEFREE |
This polymorphism (valine to methionine at codon 158) has been previously reported to influence the activity of COMT by three to four-fold and has recently been reported to be associated with OCD.1 We tested for linkage using an autosomal dominant model with reduced penetrance and non-parametric methods.
|
10523824 |
1999 |
Malignant neoplasm of breast
|
|
0.100 |
GeneticVariation
|
BEFREE |
A valine-108-methionine polymorphism in exon 4 of the catechol-O-methyltransferase (COMT) gene causes a 3- to 4-fold reduction in enzyme activity and has been associated with an increased risk of breast cancer.
|
11142424 |
2000 |
Breast Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
A valine-108-methionine polymorphism in exon 4 of the catechol-O-methyltransferase (COMT) gene causes a 3- to 4-fold reduction in enzyme activity and has been associated with an increased risk of breast cancer.
|
11142424 |
2000 |
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
The results failed to show significant association between val158met polymorphism and schizophrenia, violence or suicide.
|
11150892 |
2001 |
Gilles de la Tourette syndrome
|
|
0.010 |
GeneticVariation
|
BEFREE |
We investigated both the role of the insertion/deletion polymorphism in the promoter region of the serotonin transporter gene (5-HTTLPR) and that of the Val-158-Met substitution in the catechol-O-methyl-transferase (COMT) gene in conferring susceptibility to TS.
|
11166081 |
2000 |
Anorexia Nervosa
|
|
0.060 |
GeneticVariation
|
BEFREE |
Catechol-O-methyltransferase (COMT) is a candidate gene for mediating susceptibility to AN since it is involved in the dopamine catabolism and because its functional polymorphism (Val/Met 158) determines high (H) and low (L) enzymatic activity alleles.
|
11317231 |
2001 |
Malignant neoplasm of breast
|
|
0.100 |
GeneticVariation
|
BEFREE |
Relationship between the Val158Met polymorphism of catechol O-methyl transferase and breast cancer.
|
11434504 |
2001 |
Breast Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
Relationship between the Val158Met polymorphism of catechol O-methyl transferase and breast cancer.
|
11434504 |
2001 |
Breast Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
Several studies have indicated that the val108met COMT polymorphism, which results in a 3-4-fold decrease in activity, is associated with increased breast cancer risk.
|
11577006 |
2001 |
Malignant neoplasm of breast
|
|
0.100 |
GeneticVariation
|
BEFREE |
Several studies have indicated that the val108met COMT polymorphism, which results in a 3-4-fold decrease in activity, is associated with increased breast cancer risk.
|
11577006 |
2001 |
Breast Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
To date, three studies in Caucasians and one study in Chinese have been conducted to determine the association with breast cancer risk of a functional polymorphism (G-to-A, Val158Met) of this enzyme, but the results were inconsistent.
|
11706521 |
2001 |
Malignant neoplasm of breast
|
|
0.100 |
GeneticVariation
|
BEFREE |
To date, three studies in Caucasians and one study in Chinese have been conducted to determine the association with breast cancer risk of a functional polymorphism (G-to-A, Val158Met) of this enzyme, but the results were inconsistent.
|
11706521 |
2001 |
Panic Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
A well-characterized single nucleotide polymorphism (472G/A-Val/Met-SNP8) in the coding sequence of the catechol-O-methyltransferase (COMT) gene leads to a three- to fourfold difference in enzymatic activity and clinical and animal studies suggest a role in anxiety states like panic disorder.
|
11950461 |
2002 |