|
Crohn Disease
|
|
0.800 |
GeneticVariation
|
BEFREE |
D299G and T399I were related to CD only in patients carrying NOD2 variants (NOD2+/TLR4+ haplotype) (p=0.036; OR=1.924), increasing the risk to develop CD when 1007insC and TLR4 variants were both present (OR=4.886).
|
27290609 |
2016 |
|
Ulcerative Colitis
|
|
0.800 |
GeneticVariation
|
BEFREE |
Overall, no heterozygous or homozygous single nucleotide polymorphism mutations were found in patients with Crohn's disease and ulcerative colitis both in the TLR4 gene Asp299Gly, Thr399Ile and the TLR2 gene Arg677Trp, Arg753Gln in the Zhuang population from the Guangxi Zhuang Autonomous Region of China.
|
23239925 |
2012 |
|
Ulcerative Colitis
|
|
0.800 |
GeneticVariation
|
BEFREE |
TLR4 variant D299G showed significant association, with UC (P=0.009) and CD (P=0.039).
|
23470644 |
2013 |
|
Crohn Disease
|
|
0.800 |
GeneticVariation
|
BEFREE |
Toll-like receptor (TLR) polymorphisms, and especially TLR-4 Asp299Gly and TLR-4 Thr399Ile, have been linked with Crohn's disease (CD) and to a lesser extent with ulcerative colitis (UC), CD behavior, and compromised seroreactivity to microbial antigens.
|
22918682 |
2013 |
|
Crohn Disease
|
|
0.800 |
GeneticVariation
|
BEFREE |
To examine whether TLR4 Asp299Gly, CD14-260C/T, TNF-1031T/C, TNF-863C/A, TNF-857C/T, TACE-172C/T, and TACE-154C/A polymorphisms are associated with Crohn disease in the Ashkenazi Jewish population, we analyzed families with at least 1 child with Crohn disease for association with these mutations using a family-based association test (transmission disequilibrium test) for analysis.
|
18493210 |
2008 |
|
Crohn Disease
|
|
0.800 |
GeneticVariation
|
BEFREE |
The meta-analysis provides evidence that TLR2 Arg753Gln is not associated with CD and UC susceptibility in Asians; TLR4 Asp299Gly is associated with CD and UC susceptibility in Caucasians, but not Asians.
|
26023918 |
2015 |
|
Crohn Disease
|
|
0.800 |
GeneticVariation
|
BEFREE |
CD susceptibility polymorphisms ATG16L1 rs2241880, ICAM1 rs5498, IL4 rs2070874, IL17F rs763780, IRGM rs13361189, ITLN1 rs2274910, LRRK2 rs11175593, and TLR4 rs4986790 were genotyped in a Portuguese population (511 CD patients, 626 controls) and assessed for association with CD clinical characteristics.
|
22573572 |
2013 |
|
Ankylosing spondylitis
|
|
0.760 |
GeneticVariation
|
BEFREE |
No significant difference between the frequencies of the Asp299Gly genotype or the Thr399Ile genotype between patients with AS and healthy HLA-B27 controls was found.
|
16837493 |
2006 |
|
Ankylosing spondylitis
|
|
0.760 |
GeneticVariation
|
BEFREE |
The aim of this study was to investigate the clinical characteristics and frequency of TLR4 polymorphisms (Asp299Gly and Thr 399Ile) in a cohort of Brazilian patients with AS.
|
27692393 |
2018 |
|
Ankylosing spondylitis
|
|
0.760 |
GeneticVariation
|
GWASCAT |
Analysis of five chronic inflammatory diseases identifies 27 new associations and highlights disease-specific patterns at shared loci.
|
26974007 |
2016 |
|
Ankylosing spondylitis
|
|
0.760 |
GeneticVariation
|
BEFREE |
There is no evidence for involvement of the CD14 C-260T or TLR4 A896G polymorphisms in susceptibility to AS.
|
15647432 |
2005 |
|
Ankylosing spondylitis
|
|
0.760 |
GeneticVariation
|
BEFREE |
The present study might suggest that TLR4 D299G/T399I polymorphisms are not associated with RA/AS susceptibility.
|
22717291 |
2012 |
|
Ankylosing spondylitis
|
|
0.760 |
GeneticVariation
|
BEFREE |
The minor allele frequency for the Asp299Gly variant (G) was significantly higher in AS cases compared to controls (7.5% vs 2.6%, respectively; OR 3.10, p = 0.037).
|
17143969 |
2007 |
|
Ankylosing spondylitis
|
|
0.760 |
GeneticVariation
|
BEFREE |
Toll-like receptor 4 Asp299Gly and Thr399Ile polymorphisms do not contribute to disease susceptibility in either AS or ReA.
|
16567359 |
2006 |
|
Psoriasis
|
|
0.710 |
GeneticVariation
|
GWASCAT |
Analysis of five chronic inflammatory diseases identifies 27 new associations and highlights disease-specific patterns at shared loci.
|
26974007 |
2016 |
|
Psoriasis
|
|
0.710 |
GeneticVariation
|
BEFREE |
Significant association was observed between a missense variant rs4986790 of TLR4 (Asp229Gly) and plaque type psoriasis (p = 2 × 10(-4)) which was also notable in those with psoriatic arthritis (p = 2 × 10(-4)) and early-onset psoriasis (p = 8 × 10(-4)).
|
26830904 |
2016 |
|
Blood Protein Measurement
|
|
0.700 |
GeneticVariation
|
GWASCAT |
Genomic atlas of the human plasma proteome.
|
29875488 |
2018 |
|
Cholangitis, Sclerosing
|
|
0.700 |
GeneticVariation
|
GWASCAT |
Analysis of five chronic inflammatory diseases identifies 27 new associations and highlights disease-specific patterns at shared loci.
|
26974007 |
2016 |
|
Malignant neoplasm of stomach
|
|
0.100 |
GeneticVariation
|
BEFREE |
Based on our meta-analysis, the TLR signalling pathway is involved in gastric carcinogenesis, TLR4 Asp299Gly and TLR2 -196 to -174del showing associations with GC in an ethnic-specific manner.
|
23565226 |
2013 |
|
Malignant neoplasm of stomach
|
|
0.100 |
GeneticVariation
|
BEFREE |
The host response to H. pylori has been related to genetic polymorphisms that influence both innate and adaptive immune responses.Our aim was to investigate whether the presence of the TLR4 Asp299Gly, TLR4 Thr399Ile and IL-8-251 A/T polymorphisms had any influence in the development of distal GC in a Mexican population.
|
17462092 |
2007 |
|
Stomach Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
TLR4/D299G/T399I polymorphisms were more frequent in duodenal ulcer and showed a trend in gastric cancer, when compared with non-atrophic gastritis.
|
18755634 |
2008 |
|
Stomach Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
Toll-like receptor 4 (TLR4) Asp299Gly and Thr399Ile polymorphisms were reported to be a risk factor of gastric carcinoma or its precursors in Caucasian and Indian population, but these polymorphisms are absent in Japanese.
|
19191896 |
2009 |
|
Malignant neoplasm of stomach
|
|
0.100 |
GeneticVariation
|
BEFREE |
Moreover, in terms of stratified analyses by cancer type for SNP rs4986790, significantly elevated risk was observed to be associated with G allele in gastric cancer and 'other cancers'.
|
23084080 |
2013 |
|
Inflammatory Bowel Diseases
|
|
0.100 |
GeneticVariation
|
BEFREE |
Only the Asp299Gly polymorphism has been consistently genotyped in previous TLR4 studies with IBD patients, therefore other TLR4 variants with stronger associations with IBD may exist.
|
17850411 |
2007 |
|
Malignant neoplasm of stomach
|
|
0.100 |
GeneticVariation
|
BEFREE |
Toll-like receptor 4 Asp299Gly and Thr399Ile polymorphisms in gastric cancer of intestinal and diffuse histotypes.
|
18826495 |
2008 |