|
Rheumatoid Arthritis
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our overall analyses indicated that TLR4 Asp299Gly polymorphism might contribute to RA pathogenesis.
|
25499175 |
2015 |
|
Stomach Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
However, we detected that A allele carriers of the TLR4 Asp299Gly polymorphism might have an increase risk of gastric cancer in the Helicobacter pylori-positive population (G allele vs. A allele: OR=2.01, 95%CI: 1.22, 3.31).
|
24007538 |
2013 |
|
Inflammatory Bowel Diseases
|
|
0.100 |
GeneticVariation
|
BEFREE |
Two recent meta-analyses showed that D299G is associated with inflammatory bowel disease and gastrointestinal cancers risk, two pathological states in which the luminal microbial flora-host cells interaction may be implicated.
|
23275193 |
2013 |
|
Inflammatory Bowel Diseases
|
|
0.100 |
GeneticVariation
|
BEFREE |
To investigate the distribution of CARD15/NOD2 (Arg702Trp, Gly908Arg and Leu1007fsinsC) and TLR4 (Asp299Gly) polymorphisms in Chilean patients with IBD.Methods.
|
16840031 |
2006 |
|
Rheumatoid Arthritis
|
|
0.100 |
GeneticVariation
|
BEFREE |
The aim of this study was to determine whether the +896 A-->G substitution of the Toll-like receptor 4 (TLR4) gene, causing the Asp299-->Gly change in the extracellular domain of TLR4, influences treatment response in recent-onset rheumatoid arthritis.
|
16606645 |
2006 |
|
Malignant neoplasm of stomach
|
|
0.100 |
GeneticVariation
|
BEFREE |
However, we detected that A allele carriers of the TLR4 Asp299Gly polymorphism might have an increase risk of gastric cancer in the Helicobacter pylori-positive population (G allele vs. A allele: OR=2.01, 95%CI: 1.22, 3.31).
|
24007538 |
2013 |
|
Inflammatory Bowel Diseases
|
|
0.100 |
GeneticVariation
|
BEFREE |
The c.1-260C>T promoter variant of CD14 but not the c.896A>G (p.D299G) variant of toll-like receptor 4 (TLR4) genes is associated with inflammatory bowel disease.
|
18174680 |
2007 |
|
Malignant neoplasm of stomach
|
|
0.100 |
GeneticVariation
|
BEFREE |
Asp299Gly and Thr399Ile polymorphisms in TLR4 have been associated with a variety of inflammatory and infectious conditions including gastric cancer.
|
24295404 |
2014 |
|
Malignant neoplasm of stomach
|
|
0.100 |
GeneticVariation
|
BEFREE |
To investigate toll-like receptor 2 (TLR2) -196 to -174 del, and TLR4 (+896A/G rs4986790 and +1196C/T rs4986791) polymorphisms at risk of chronic gastritis and gastric cancer in a Brazilian population and association of gastric lesions with risk factors such as smoking, alcohol intake and Helicobacter pylori infection.
|
22468087 |
2012 |
|
Rheumatoid Arthritis
|
|
0.100 |
GeneticVariation
|
BEFREE |
There were no associations of TLR4 rs11536878 and rs4986790 SNPs with RA disease activity progression.
|
25573402 |
2015 |
|
Stomach Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
The host response to H. pylori has been related to genetic polymorphisms that influence both innate and adaptive immune responses.Our aim was to investigate whether the presence of the TLR4 Asp299Gly, TLR4 Thr399Ile and IL-8-251 A/T polymorphisms had any influence in the development of distal GC in a Mexican population.
|
17462092 |
2007 |
|
Stomach Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
Toll-like receptor 4 Asp299Gly and Thr399Ile polymorphisms in gastric cancer of intestinal and diffuse histotypes.
|
18826495 |
2008 |
|
Malignant neoplasm of stomach
|
|
0.100 |
GeneticVariation
|
BEFREE |
TLR4/D299G/T399I polymorphisms were more frequent in duodenal ulcer and showed a trend in gastric cancer, when compared with non-atrophic gastritis.
|
18755634 |
2008 |
|
Inflammatory Bowel Diseases
|
|
0.100 |
GeneticVariation
|
BEFREE |
No association of IBD with the TLR4 SNPs was found in either cohort (allele frequencies: D299G-controls 3.9%, CD 3.7%, UC 3.4%, P > 0.05; T399I-controls 2.9%, CD 3.0%, UC 3.4%, P > 0.05).
|
18680223 |
2008 |
|
Inflammatory Bowel Diseases
|
|
0.100 |
GeneticVariation
|
BEFREE |
In addition, a statistically significant association between TLR4 Asp299Gly polymorphism and IBD was observed among high quality studies evaluating Caucasians, but not Asians.
|
26023918 |
2015 |
|
Rheumatoid Arthritis
|
|
0.100 |
GeneticVariation
|
BEFREE |
The present study might suggest that TLR4 D299G/T399I polymorphisms are not associated with RA/AS susceptibility.
|
22717291 |
2012 |
|
Inflammatory Bowel Diseases
|
|
0.100 |
GeneticVariation
|
BEFREE |
A TDT on 318 IBD trios demonstrated preferential transmission of the TLR4 Asp299Gly polymorphism from heterozygous parents to affected children (T/U: 68/34, p = 0.01).
|
15194649 |
2004 |
|
Rheumatoid Arthritis
|
|
0.100 |
GeneticVariation
|
BEFREE |
In summary, results in our study do not support the hypothesis that the rs4986790 (+896A>G, Asp299Gly) TLR4 variant may influence predisposition for subclinical atherosclerosis and clinically evident CV disease in RA patients.
|
22360682 |
2012 |
|
Inflammatory Bowel Diseases
|
|
0.100 |
GeneticVariation
|
BEFREE |
However, meta-analysis demonstrated significantly higher frequencies of both Asp299Gly and Thr399Ile SNPs in IBD and CD and for 399Ileu carriage in UC patients.
|
25492126 |
2014 |
|
Inflammatory Bowel Diseases
|
|
0.100 |
GeneticVariation
|
BEFREE |
Two commonly occurring SNPs in the human TLR4 gene (Asp299Gly and Thr399Ile) have been shown to be associated with increased risk of Gram-negative bacteremia in sepsis patients and with susceptibility to inflammatory bowel disease.
|
18034244 |
2008 |
|
Rheumatoid Arthritis
|
|
0.100 |
GeneticVariation
|
BEFREE |
To analyze the association between the genetic polymorphisms within TLR4 gene and the susceptibility to RA in Chinese people, two functional variants, Asp299Gly and Thr399Ile, in the TLR4 gene were genotyped using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) and direct sequencing techniques from 213 RA patients and 247 ethnically matched controls.
|
20306049 |
2010 |
|
Inflammatory Bowel Diseases
|
|
0.100 |
GeneticVariation
|
BEFREE |
Moreover, the TLR4 rs4986790 polymorphism was significantly correlated with the risk of IBD in West Asians, while the TLR9 rs352140 polymorphism was significantly associated with the risk of IBD in Africans.
|
30617966 |
2019 |
|
Rheumatoid Arthritis
|
|
0.100 |
GeneticVariation
|
BEFREE |
The Mal S180L and TLR4 G299D polymorphisms do not contribute to RA susceptibility or severity either individually or in combination.
|
18180278 |
2008 |
|
Rheumatoid Arthritis
|
|
0.100 |
GeneticVariation
|
BEFREE |
The functional variant (Asp299gly) of toll-like receptor 4 (TLR4) influences TLR4-mediated cytokine production in rheumatoid arthritis.
|
18381796 |
2008 |
|
Stomach Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
Nine variants on nine genes were rated as presenting strong cumulative epidemiological evidence for a nominally significant association with GC risk, including <i>APE1</i> (rs1760944), <i>DNMT1</i> (rs16999593), <i>ERCC5</i> (rs751402), <i>GSTT1</i> (null/presence), <i>MDM2</i> (rs2278744), <i>PPARG</i> (rs1801282), <i>TLR4</i> (rs4986790), <i>IL-17F</i> (rs763780), and <i>CASP8</i> (rs3834129).
|
31516756 |
2019 |