|
Acute myocardial infarction
|
|
0.010 |
GeneticVariation
|
BEFREE |
Three VEGF gene single nucleotide polymorphisms (SNPs) (-2578A>C rs699947, -634C>G rs2010963 and +936C>T rs3025039) were genotyped in 516 control subjects of the OPERA (Oulu Project Elucidating Risk of Atherosclerosis) cohort and in 251 survivors of AMI.
|
19089753 |
2009 |
|
Age related macular degeneration
|
|
0.020 |
GeneticVariation
|
BEFREE |
VEGF A (rs699947 and rs833061) and VEGFR2 (rs2071559) gene polymorphisms are not associated with AMD susceptibility in a Spanish population.
|
23971975 |
2013 |
|
Age related macular degeneration
|
|
0.020 |
GeneticVariation
|
BEFREE |
VEGF rs2146323 and rs699947 SNPs have no relationship to exudative AMD formation, and none of these seem to have any effect on anti-VEGF response.
|
27404493 |
2016 |
|
Alzheimer's Disease
|
|
0.010 |
GeneticVariation
|
BEFREE |
To further evaluate these findings, we genotyped two SNPs in the VEGF gene (rs699947 [-2578]) and rs1570360 [-1154]) by TaqMan Allelic Discrimination in a study sample including AD patients (n = 801) and controls (n = 286).
|
19842071 |
2010 |
|
Bladder Neoplasm
|
|
0.030 |
GeneticVariation
|
BEFREE |
In summary, our study showed evidence that the VEGF rs699947 polymorphism was obviously associated with an increased risk of bladder cancer and renal cell carcinoma, particularly in Asian population, while no significant association was observed in overall urologic neoplasms.
|
30195633 |
2018 |
|
Bladder Neoplasm
|
|
0.030 |
GeneticVariation
|
BEFREE |
As to ethnicity subgroup analysis, rs699947 and rs3025039 polymorphisms were thought as a risk factor for BCa risk in Asian population, while a decreased association was revealed between rs699947 (C > A) A-allele and BCa risk in African population under dominant, recessive, homozygous, heterozygous and allele contrast genetic models.
|
30849545 |
2019 |
|
Bladder Neoplasm
|
|
0.030 |
GeneticVariation
|
BEFREE |
We found that the A allele of rs699947 and the A allele of rs833052 within VEGF gene, interaction between rs2010963 and smoking, haplotype containing the rs2010963- C and rs833052- A alleles were all associated with increased bladder cancer risk.
|
28206971 |
2017 |
|
Carcinoma of bladder
|
|
0.030 |
GeneticVariation
|
BEFREE |
We found that the A allele of rs699947 and the A allele of rs833052 within VEGF gene, interaction between rs2010963 and smoking, haplotype containing the rs2010963- C and rs833052- A alleles were all associated with increased bladder cancer risk.
|
28206971 |
2017 |
|
Carcinoma of bladder
|
|
0.030 |
GeneticVariation
|
BEFREE |
In summary, our study showed evidence that the VEGF rs699947 polymorphism was obviously associated with an increased risk of bladder cancer and renal cell carcinoma, particularly in Asian population, while no significant association was observed in overall urologic neoplasms.
|
30195633 |
2018 |
|
Carcinoma of bladder
|
|
0.030 |
GeneticVariation
|
BEFREE |
As to ethnicity subgroup analysis, rs699947 and rs3025039 polymorphisms were thought as a risk factor for BCa risk in Asian population, while a decreased association was revealed between rs699947 (C > A) A-allele and BCa risk in African population under dominant, recessive, homozygous, heterozygous and allele contrast genetic models.
|
30849545 |
2019 |
|
Carcinoma of lung
|
|
0.020 |
GeneticVariation
|
BEFREE |
The aim of this meta-analysis is to generate large-scale evidence on whether common vascular endothelial growth factor (VEGF) gene polymorphisms (-2578C/A [dbSNP: rs699947] and -460C/T [dbSNP: rs833061]) are associated with lung cancer.
|
23982876 |
2014 |
|
Carcinoma of lung
|
|
0.020 |
GeneticVariation
|
BEFREE |
rs833061 and rs699947 on promoter gene of vascular endothelial growth factor (VEGF) and associated lung cancer susceptibility and survival: a meta-analysis.
|
25468805 |
2014 |
|
cervical cancer
|
|
0.020 |
GeneticVariation
|
BEFREE |
Specific VEGF variants (rs699947, rs1570360) and haplotype (CTGCCAG) may contribute to the development of CC among Tunisian women.
|
25541433 |
2015 |
|
cervical cancer
|
|
0.020 |
GeneticVariation
|
BEFREE |
Compared with the G allele, the A allele of rs699947 was associated with a significantly increased risk of cervical cancer in subjects above 20 years and who were positive for human papillomavirus 16 (HPV-16) or HPV-18 infection.
|
26535675 |
2015 |
|
Cervix carcinoma
|
|
0.020 |
GeneticVariation
|
BEFREE |
Compared with the G allele, the A allele of rs699947 was associated with a significantly increased risk of cervical cancer in subjects above 20 years and who were positive for human papillomavirus 16 (HPV-16) or HPV-18 infection.
|
26535675 |
2015 |
|
Cervix carcinoma
|
|
0.020 |
GeneticVariation
|
BEFREE |
Specific VEGF variants (rs699947, rs1570360) and haplotype (CTGCCAG) may contribute to the development of CC among Tunisian women.
|
25541433 |
2015 |
|
Childhood Osteosarcoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
By stratified analysis, AA genotype of rs699947 was associated with an increased risk of osteosarcoma</span> in those with shorter age, males and a family history of cancer, and GG genotype of rs2010963 was correlated with an increased risk of osteosarcoma in those with shorter age, females and a family history of cancer.
|
25550863 |
2014 |
|
Chronic liver disease
|
|
0.010 |
GeneticVariation
|
BEFREE |
Difference of polymorphism VEGF-gene rs699947 in Indonesian chronic liver disease population.
|
28837651 |
2017 |
|
Colorectal Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
This study aimed to explore the effects of vascular endothelial growth factor A (<i>VEGFA</i>) gene polymorphisms (rs699947 and rs833061) on Bevacizumab (BEV) treatment in colorectal cancer (CRC) patients.
|
29285265 |
2017 |
|
Congenital heart disease
|
|
0.010 |
GeneticVariation
|
BEFREE |
We evaluated the association of VEGFA polymorphisms c.-2578C>A (rs699947), c.-1154G>A (rs1570360) and c.-634C>G (rs2010963) with congenital heart disease in Chilean patients with microdeletion 22q11.
|
20140301 |
2009 |
|
Conventional (Clear Cell) Renal Cell Carcinoma
|
|
0.040 |
GeneticVariation
|
BEFREE |
And VEGF-rs699947 polymorphism was also identified an increased risk of renal cell carcinoma (RCC) in allelic, heterozygote, dominant, homozygote, and recessive models.
|
29942264 |
2018 |
|
Conventional (Clear Cell) Renal Cell Carcinoma
|
|
0.040 |
GeneticVariation
|
BEFREE |
The pooled OR indicated that rs699947 polymorphism was significantly associated with RCC risk in all genetic models.
|
28356760 |
2017 |
|
Conventional (Clear Cell) Renal Cell Carcinoma
|
|
0.040 |
GeneticVariation
|
BEFREE |
Our meta-analysis suggested that there may be a relationship between the VEGF rs2010963, rs3025039 and rs699947 polymorphisms and RCC susceptibility.
|
28562357 |
2017 |
|
Conventional (Clear Cell) Renal Cell Carcinoma
|
|
0.040 |
GeneticVariation
|
BEFREE |
In summary, our study showed evidence that the VEGF rs699947 polymorphism was obviously associated with an increased risk of bladder cancer and renal cell carcinoma, particularly in Asian population, while no significant association was observed in overall urologic neoplasms.
|
30195633 |
2018 |
|
Coronary Arteriosclerosis
|
|
0.030 |
GeneticVariation
|
BEFREE |
We were unable to find strong association between analyzed polymorphisms in growth factors and the severity of coronary artery disease, although there was a trend toward association between rs699947 and the severity of CAD in patients without previous MI.
|
27835972 |
2016 |