|
Diabetic Retinopathy
|
|
0.060 |
GeneticVariation
|
BEFREE |
After adjusting for covariates, a significant association of DR was observed with the homozygous genotype of the minor allele for promoter SNPs rs699947 (odds ratio (OR)=3.54, 95% confidence interval (CI): 1.12-11.19), rs833061 (OR=3.72, 95% CI: 1.17-11.85) and rs13207351 (OR=3.76, 95% CI: 1.21-11.71).
|
22162628 |
2011 |
|
Diabetic Retinopathy
|
|
0.060 |
GeneticVariation
|
BEFREE |
After adjustment for covariates, significant association of DR remained with the homozygous genotype of the minor allele for the SNPs rs699947 (odds ratio [OR] = 3.54, 95% confidence interval [CI]: 1.12-11.19), rs833061 (OR = 3.72, 95% CI: 1.17-11.85), rs13207351 (OR = 3.76, 95% CI: 1.21-11.71), and rs2146323 (OR = 2.8, 95% CI: 1.46-5.37) in the VEGF gene as well as the SNP rs2071559 (OR = 1.62, 95% CI: 1.08-2.41) in the KDR gene.
|
24623964 |
2014 |
|
Coronary heart disease
|
|
0.050 |
GeneticVariation
|
BEFREE |
All of the combined effects of rs699947 (CC/CA) and rs2305948 (TT), rs3025039 (TT) and rs2305948 (TT), rs3025039 (CT) and rs1870377 (AA) had positive effects on the risk of CHD, respectively (all P < 0.05).
|
27175642 |
2016 |
|
Mucocutaneous Lymph Node Syndrome
|
|
0.010 |
GeneticVariation
|
BEFREE |
An association with susceptibility to KD was observed with 2 of the 6 single-nucleotide polymorphisms analyzed in VEGF: -2594 A>C (rs699947) and the 236 bp 3' of STP C>T (rs3025039).
|
16645995 |
2006 |
|
Prostate carcinoma
|
|
0.020 |
GeneticVariation
|
BEFREE |
And rs699947 polymorphism was also identified an increased risk of renal cell carcinoma (RCC) under dominant, recessive, homozygous, heterozygous and allelic contrast genetic models, while no association was observed in prostate cancer (PCa).
|
30195633 |
2018 |
|
Malignant neoplasm of prostate
|
|
0.020 |
GeneticVariation
|
BEFREE |
And rs699947 polymorphism was also identified an increased risk of renal cell carcinoma (RCC) under dominant, recessive, homozygous, heterozygous and allelic contrast genetic models, while no association was observed in prostate cancer (PCa).
|
30195633 |
2018 |
|
Renal Cell Carcinoma
|
|
0.040 |
GeneticVariation
|
BEFREE |
And VEGF-rs69</span>9947 polymorphism was also identified an increased risk of renal cell carcinoma (RCC) in allelic, heterozygote, dominant, homozygote, and recessive models.
|
29942264 |
2018 |
|
Conventional (Clear Cell) Renal Cell Carcinoma
|
|
0.040 |
GeneticVariation
|
BEFREE |
And VEGF-rs699947 polymorphism was also identified an increased risk of renal cell carcinoma (RCC) in allelic, heterozygote, dominant, homozygote, and recessive models.
|
29942264 |
2018 |
|
Bladder Neoplasm
|
|
0.030 |
GeneticVariation
|
BEFREE |
As to ethnicity subgroup analysis, rs699947 and rs3025039 polymorphisms were thought as a risk factor for BCa risk in Asian population, while a decreased association was revealed between rs699947 (C > A) A-allele and BCa risk in African population under dominant, recessive, homozygous, heterozygous and allele contrast genetic models.
|
30849545 |
2019 |
|
Malignant neoplasm of urinary bladder
|
|
0.030 |
GeneticVariation
|
BEFREE |
As to ethnicity subgroup analysis, rs699947 and rs3025039 polymorphisms were thought as a risk factor for BCa risk in Asian population, while a decreased association was revealed between rs699947 (C > A) A-allele and BCa risk in African population under dominant, recessive, homozygous, heterozygous and allele contrast genetic models.
|
30849545 |
2019 |
|
Carcinoma of bladder
|
|
0.030 |
GeneticVariation
|
BEFREE |
As to ethnicity subgroup analysis, rs699947 and rs3025039 polymorphisms were thought as a risk factor for BCa risk in Asian population, while a decreased association was revealed between rs699947 (C > A) A-allele and BCa risk in African population under dominant, recessive, homozygous, heterozygous and allele contrast genetic models.
|
30849545 |
2019 |
|
Diabetic foot ulcer
|
|
0.010 |
GeneticVariation
|
BEFREE |
But no significant differences were detected in rs13207351 genotype and allele distributions between patients and control groups (P > .05).Individuals carrying VEGF rs699947 A allele show low susceptibility to DFU in the Chinese Han population.
|
29768333 |
2018 |
|
Urologic Neoplasms
|
|
0.010 |
GeneticVariation
|
BEFREE |
By pooling all eligible studies, we found that the VEGF rs699947 polymorphism was not associated with overall urologic neoplasms.
|
30195633 |
2018 |
|
Childhood Osteosarcoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
By stratified analysis, AA genotype of rs699947 was associated with an increased risk of osteosarcoma</span> in those with shorter age, males and a family history of cancer, and GG genotype of rs2010963 was correlated with an increased risk of osteosarcoma in those with shorter age, females and a family history of cancer.
|
25550863 |
2014 |
|
Osteosarcoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
By stratified analysis, AA genotype of rs699947 was associated with an increased risk of osteosarcoma</span> in those with shorter age, males and a family history of cancer, and GG genotype of rs2010963 was correlated with an increased risk of osteosarcoma in those with shorter age, females and a family history of cancer.
|
25550863 |
2014 |
|
Osteosarcoma of bone
|
|
0.010 |
GeneticVariation
|
BEFREE |
By stratified analysis, AA genotype of rs699947 was associated with an increased risk of osteosarcoma</span> in those with shorter age, males and a family history of cancer, and GG genotype of rs2010963 was correlated with an increased risk of osteosarcoma in those with shorter age, females and a family history of cancer.
|
25550863 |
2014 |
|
Malignant Neoplasms
|
|
0.030 |
GeneticVariation
|
BEFREE |
By stratified analysis, AA genotype of rs699947 was associated with an increased risk of osteosarcoma in those with shorter age, males and a family history of cancer, and GG genotype of rs2010963 was correlated with an increased risk of osteosarcoma in those with shorter age, females and a family history of cancer.
|
25550863 |
2014 |
|
Primary malignant neoplasm
|
|
0.030 |
GeneticVariation
|
BEFREE |
By stratified analysis, AA genotype of rs699947 was associated with an increased risk of osteosarcoma in those with shorter age, males and a family history of cancer, and GG genotype of rs2010963 was correlated with an increased risk of osteosarcoma in those with shorter age, females and a family history of cancer.
|
25550863 |
2014 |
|
Liver carcinoma
|
|
0.020 |
GeneticVariation
|
BEFREE |
Collectively, this meta-analysis proved that VDR rs7975232, VDR rs2228570, VEGF rs699947, VEGF rs3025039, IL-18 rs1946518, and MBL rs7096206 polymorphisms may confer susceptibility to HCC in certain populations.
|
31830994 |
2019 |
|
Cervix carcinoma
|
|
0.020 |
GeneticVariation
|
BEFREE |
Compared with the G allele, the A allele of rs699947 was associated with a significantly increased risk of cervical cancer in subjects above 20 years and who were positive for human papillomavirus 16 (HPV-16) or HPV-18 infection.
|
26535675 |
2015 |
|
cervical cancer
|
|
0.020 |
GeneticVariation
|
BEFREE |
Compared with the G allele, the A allele of rs699947 was associated with a significantly increased risk of cervical cancer in subjects above 20 years and who were positive for human papillomavirus 16 (HPV-16) or HPV-18 infection.
|
26535675 |
2015 |
|
Malignant tumor of cervix
|
|
0.020 |
GeneticVariation
|
BEFREE |
Compared with the G allele, the A allele of rs699947 was associated with a significantly increased risk of cervical cancer in subjects above 20 years and who were positive for human papillomavirus 16 (HPV-16) or HPV-18 infection.
|
26535675 |
2015 |
|
Chronic liver disease
|
|
0.010 |
GeneticVariation
|
BEFREE |
Difference of polymorphism VEGF-gene rs699947 in Indonesian chronic liver disease population.
|
28837651 |
2017 |
|
Retinal Diseases
|
|
0.020 |
GeneticVariation
|
BEFREE |
Family-based analyses of severe retinopathy provide evidence of excess transmission of C at rs699947 (P = 0.029), T at rs3025021 (P = 0.013), and the C-T haplotype from both SNPs (P = 0.035).
|
17513698 |
2007 |
|
Primary malignant neoplasm
|
|
0.030 |
GeneticVariation
|
BEFREE |
Four polymorphisms of the above excluding rs699947 and rs3025039 showed significant association with malignancy, and we observed the presence of positive correlation between haplotype CCGGCC and increased expression of VEGF-A in both plasma and tissues which also correlated with poor prognosis and recurrence suggesting a probable increase in resistance to treatment in such carriers.
|
26264619 |
2016 |