|
Polycystic Ovary Syndrome
|
|
0.010 |
GeneticVariation
|
BEFREE |
VEGF levels in rs699947 (AA-major homozygous), rs3025039 (CC-major homozygous) and rs833061 (TT & CC-major & minor homozygous) genotypes were significantly higher in PCOS.
|
31385237 |
2019 |
|
Multiple Sclerosis
|
|
0.010 |
GeneticVariation
|
BEFREE |
Regarding the VEGF rs699947 polymorphism allelic distribution, the C allele frequency was significantly higher in the control group than in the case group (71.3% versus 61%, respectively, p = 0.009) and decreased the MS susceptibility by 1.6-fold (odds ratio = 1.6, 95% confidence interval = 1.2-2.2).
|
31652374 |
2019 |
|
Urologic Neoplasms
|
|
0.010 |
GeneticVariation
|
BEFREE |
By pooling all eligible studies, we found that the VEGF rs699947 polymorphism was not associated with overall urologic neoplasms.
|
30195633 |
2018 |
|
Diabetic foot ulcer
|
|
0.010 |
GeneticVariation
|
BEFREE |
But no significant differences were detected in rs13207351 genotype and allele distributions between patients and control groups (P > .05).Individuals carrying VEGF rs699947 A allele show low susceptibility to DFU in the Chinese Han population.
|
29768333 |
2018 |
|
Renal carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
VEGF-rs699947 polymorphism was also identified as an increased risk factor for renal carcinoma.
|
29942264 |
2018 |
|
Myocardial Ischemia
|
|
0.010 |
GeneticVariation
|
BEFREE |
Moreover, VEGF rs699947 and rs2010963 polymorphisms may serve as genetic biomarkers of poor collateral circulation after myocardial ischemia.
|
30317903 |
2018 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.010 |
GeneticVariation
|
BEFREE |
Increased T2DM risk was associated with rs699947, rs1570360, and rs3025020, while reduced T2DM risk was seen with rs1547651, rs2010963, rs25648, rs3025036, and rs3025039 genotypes, thus assigning T2DM susceptibility and protection, respectively.
|
29533820 |
2018 |
|
Chronic liver disease
|
|
0.010 |
GeneticVariation
|
BEFREE |
Difference of polymorphism VEGF-gene rs699947 in Indonesian chronic liver disease population.
|
28837651 |
2017 |
|
Hepatitis, Chronic
|
|
0.010 |
GeneticVariation
|
BEFREE |
We aimed to explore differences of VEGF gene polymorphism rs699947 in chronic hepatitis, liver cirrhosis and hepatocellular carcinoma patients in Indonesian population.
|
28837651 |
2017 |
|
Erythema Multiforme
|
|
0.010 |
GeneticVariation
|
BEFREE |
The aim of this study is to analyze the relationship between functional polymorphisms in the genes encoding vascular endothelial growth factor A (VEGF-A; rs699947) and transforming growth factor beta 1 (TGF-<i>β</i>1; rs1800470) and target lesion revascularization (TLR) risk.
|
28811677 |
2017 |
|
Multiple Myeloma
|
|
0.010 |
GeneticVariation
|
BEFREE |
We found that the A allele of rs699947 within VEGF and T allele of rs2228570 within VDR gene, interaction between rs699947 and rs2228570, rs2228570 andsmoking were all associated with increased MM risk.
|
28380424 |
2017 |
|
Colorectal Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
This study aimed to explore the effects of vascular endothelial growth factor A (<i>VEGFA</i>) gene polymorphisms (rs699947 and rs833061) on Bevacizumab (BEV) treatment in colorectal cancer (CRC) patients.
|
29285265 |
2017 |
|
Parkinson Disease
|
|
0.010 |
GeneticVariation
|
BEFREE |
No significant association could be found between rs699947 and rs2010963 polymorphism and PD risk.
|
27481110 |
2016 |
|
Hypertensive disease
|
|
0.010 |
GeneticVariation
|
BEFREE |
Our results suggest that rs699947 (T>C) on KDR are associated with susceptibility to CHD under the dominant model before (OR=1.35, 95% CI: 1.05-1.73, P=0.019) and after (OR=1.33, 95% CI: 1.01-1.76, P=0.044), allowing for clinical characteristics (e.g., BMI, smoking, alcohol consumption, diabetes, and hypertension). rs2305948 (G>A) and rs1870377 (A>T) on VEGF were also found to be associated with risk of CHD under the recessive model after adjustment with multivariate regression analyses (OR=1.21, 95% CI: 1.02-1.43, P=0.029; OR=2.54, 95% CI: 1.13-5.75, P=0.025); OR=2.83, 95% CI: 1.47-5.46, P=0.002, respectively).
|
26726843 |
2016 |
|
Diabetes Mellitus
|
|
0.010 |
GeneticVariation
|
BEFREE |
Our results suggest that rs699947 (T>C) on KDR are associated with susceptibility to CHD under the dominant model before (OR=1.35, 95% CI: 1.05-1.73, P=0.019) and after (OR=1.33, 95% CI: 1.01-1.76, P=0.044), allowing for clinical characteristics (e.g., BMI, smoking, alcohol consumption, diabetes, and hypertension). rs2305948 (G>A) and rs1870377 (A>T) on VEGF were also found to be associated with risk of CHD under the recessive model after adjustment with multivariate regression analyses (OR=1.21, 95% CI: 1.02-1.43, P=0.029; OR=2.54, 95% CI: 1.13-5.75, P=0.025); OR=2.83, 95% CI: 1.47-5.46, P=0.002, respectively).
|
26726843 |
2016 |
|
Exudative age-related macular degeneration
|
|
0.010 |
GeneticVariation
|
BEFREE |
The aim of this study was to evaluate the prevalence of single nucleotide polymorphisms (SNPs) in complement factor H (CFH) Y402H and VEGF rs2146323 and rs699947 in exudative age-related macular degeneration (AMD) and their relationship with intravitreal anti-VEGF treatment response.
|
27404493 |
2016 |
|
Myocardial Infarction
|
|
0.010 |
GeneticVariation
|
BEFREE |
We were unable to find strong association between analyzed polymorphisms in growth factors and the severity of coronary artery disease, although there was a trend toward association between rs699947 and the severity of CAD in patients without previous MI.
|
27835972 |
2016 |
|
Diabetes
|
|
0.010 |
GeneticVariation
|
BEFREE |
Our results suggest that rs699947 (T>C) on KDR are associated with susceptibility to CHD under the dominant model before (OR=1.35, 95% CI: 1.05-1.73, P=0.019) and after (OR=1.33, 95% CI: 1.01-1.76, P=0.044), allowing for clinical characteristics (e.g., BMI, smoking, alcohol consumption, diabetes, and hypertension). rs2305948 (G>A) and rs1870377 (A>T) on VEGF were also found to be associated with risk of CHD under the recessive model after adjustment with multivariate regression analyses (OR=1.21, 95% CI: 1.02-1.43, P=0.029; OR=2.54, 95% CI: 1.13-5.75, P=0.025); OR=2.83, 95% CI: 1.47-5.46, P=0.002, respectively).
|
26726843 |
2016 |
|
Tetralogy of Fallot
|
|
0.010 |
GeneticVariation
|
BEFREE |
In the single SNP analyses, the mutant homozygous genotypes of -2578C/A (rs699947) and +963C/T (rs3025039) were related with an increased risk of TOF.
|
25894981 |
2015 |
|
Schizophrenia
|
|
0.010 |
GeneticVariation
|
BEFREE |
The AA genotype of rs699947 nominally decreased the risk of SCZ in recessive inheritance model (p=0.03, OR=0.65, 95%CI=0.44-0.95, adjusted p=0.18).
|
25641131 |
2015 |
|
Childhood Osteosarcoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
By stratified analysis, AA genotype of rs699947 was associated with an increased risk of osteosarcoma</span> in those with shorter age, males and a family history of cancer, and GG genotype of rs2010963 was correlated with an increased risk of osteosarcoma in those with shorter age, females and a family history of cancer.
|
25550863 |
2014 |
|
Osteosarcoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
By stratified analysis, AA genotype of rs699947 was associated with an increased risk of osteosarcoma</span> in those with shorter age, males and a family history of cancer, and GG genotype of rs2010963 was correlated with an increased risk of osteosarcoma in those with shorter age, females and a family history of cancer.
|
25550863 |
2014 |
|
Osteosarcoma of bone
|
|
0.010 |
GeneticVariation
|
BEFREE |
By stratified analysis, AA genotype of rs699947 was associated with an increased risk of osteosarcoma</span> in those with shorter age, males and a family history of cancer, and GG genotype of rs2010963 was correlated with an increased risk of osteosarcoma in those with shorter age, females and a family history of cancer.
|
25550863 |
2014 |
|
Erectile dysfunction
|
|
0.010 |
GeneticVariation
|
BEFREE |
We determined VEGF genotypes for three polymorphisms in VEGF promoter: -2578C>A (rs699947), -1154G>A (rs1570360) and -634G>C (rs2010963) in 126 patients with erectile dysfunction (ED; 66 patients with PED and 60 patients with CED).
|
23007311 |
2013 |
|
Migraine Disorders
|
|
0.010 |
GeneticVariation
|
BEFREE |
This study aimed at characterizing interactions among nine clinically relevant polymorphisms in eNOS (T(-786)C/rs2070744, the 27 bp VNTR in intron 4, the Glu298Asp/rs1799983, and two additional tagSNPs rs3918226 and rs743506), iNOS (C(-1026)A/rs2779249 and G2087A/rs2297518), and VEGF (C(-2578)A/rs699947 and G(-634)C/rs2010963) in migraine patients and control group.
|
22865486 |
2012 |