|
Addison Disease
|
|
0.010 |
GeneticVariation
|
BEFREE |
The role of a nonsynonymous CD226 (DNAX-accessory molecule-1) variant (Gly 307Ser) in isolated Addison's disease and autoimmune polyendocrinopathy type 2 pathogenesis.
|
21521299 |
2011 |
|
Addison's disease due to autoimmunity
|
|
0.010 |
GeneticVariation
|
BEFREE |
The susceptibility 'T' allele at rs763361 was found in 50·5% of patients with AAD compared to 46·5% of controls (P-value 0·16, OR 1·17; 95% CI 0·94-1·46).
|
21521299 |
2011 |
|
Arthritis, Psoriatic
|
|
0.010 |
GeneticVariation
|
BEFREE |
An association of STAT4 (rs10181656) with PsA was confirmed whereas CD226 (rs763361) was associated with PsA but not with RA, in contrast to previous reports.
|
27440135 |
2017 |
|
Autoantibody measurement
|
|
0.700 |
GeneticVariation
|
GWASDB |
Genome-wide association analysis of autoantibody positivity in type 1 diabetes cases.
|
21829393 |
2011 |
|
Autoimmune Diseases
|
|
0.090 |
GeneticVariation
|
BEFREE |
Our results demonstrate that the coding variant rs763361 in CD226 gene is associated with multiple ADs in non-European populations.
|
20338887 |
2010 |
|
Autoimmune Diseases
|
|
0.090 |
GeneticVariation
|
BEFREE |
This meta-analysis provided evidence that CD226 Gly307Ser (rs763361) is significantly associated with the risk of multiple autoimmune diseases.
|
23073294 |
2013 |
|
Autoimmune Diseases
|
|
0.090 |
GeneticVariation
|
BEFREE |
CD226 Gly307Ser association with multiple autoimmune diseases.
|
18971939 |
2009 |
|
Autoimmune Diseases
|
|
0.090 |
GeneticVariation
|
BEFREE |
This meta-analysis demonstrates the CD226 rs763361 polymorphism confers susceptibility to autoimmune disease in Europeans, South Americans and Asians, and in particular, shows that the CD226 rs763361 polymorphism is associated with SLE, SSc and T1D.
|
22941566 |
2012 |
|
Autoimmune Diseases
|
|
0.090 |
GeneticVariation
|
BEFREE |
A novel non-synonymous (Gly307Ser) variant, rs763361, of the CD226 gene on chromosome 18q22 was recently shown to be associated with multiple autoimmune diseases.
|
20887380 |
2011 |
|
Autoimmune Diseases
|
|
0.090 |
GeneticVariation
|
BEFREE |
Moreover, co-engagement of the TCR and a risk variant of CD226 that is associated with autoimmunity (rs763361) further enhanced VAV1 activation and IL-17 production.
|
29991650 |
2018 |
|
Autoimmune Diseases
|
|
0.090 |
GeneticVariation
|
BEFREE |
The nonsynonymous polymorphism rs763361 of the CD226 gene, which encodes DNAX accessory molecule 1, which is involved in T cell costimulation pathways, has recently been identified as a genetic risk factor for autoimmunity.
|
21162102 |
2011 |
|
Autoimmune Diseases
|
|
0.090 |
GeneticVariation
|
BEFREE |
A nonsynonymous polymorphism in exon 7 of the gene encoding the lymphocyte cell-surface CD226 (DNAM1) receptor, Gly307Ser (rs763361), has recently been identified as conferring risk to many autoimmune disorders.
|
21521299 |
2011 |
|
Autoimmune Diseases
|
|
0.090 |
GeneticVariation
|
BEFREE |
Recently, there has been increasing evidence that a non-synonymous exchange (Gly307Ser) in the gene for CD226 is linked to several autoimmune diseases including type 1 diabetes, multiple sclerosis (MS), rheumatoid arthritis and Grave's disease.
|
19536154 |
2009 |
|
Autoimmune Primary Adrenal Insufficiency
|
|
0.010 |
GeneticVariation
|
BEFREE |
The susceptibility 'T' allele at rs763361 was found in 50·5% of patients with AAD compared to 46·5% of controls (P-value 0·16, OR 1·17; 95% CI 0·94-1·46).
|
21521299 |
2011 |
|
Autoimmune thyroid disease (AITD)
|
|
0.010 |
GeneticVariation
|
BEFREE |
In addition to the analysis of newly available samples in T1D (2088 cases and 3289 controls) and autoimmune thyroid disease (AITD) (821 cases and 1920 controls), resulting in strong support for the Ser(307) association with T1D (P=3.46 x 10(-9)) and continued potential evidence for AITD (P=0.0345), we provide evidence for association of Gly307Ser with MS (P=4.20 x 10(-4)) and rheumatoid arthritis (RA) (P=0.017).
|
18971939 |
2009 |
|
Camurati-Engelmann Syndrome
|
|
0.020 |
GeneticVariation
|
BEFREE |
Recently, there has been increasing evidence shown that a non-synonymous exchange (Gly307Ser/rs763361) of the CD226 gene on chromosome 18q22 is linked to several autoimmune diseases (ADs) including type 1 diabetes (T1D), celiac disease (CED), rheumatoid arthritis (RA), multiple sclerosis (MS), Grave's disease, Wegener's granulomatosis (WG), psoriasis, and primary sicca syndrome (pSS).
|
23073294 |
2013 |
|
Camurati-Engelmann Syndrome
|
|
0.020 |
GeneticVariation
|
BEFREE |
We show that rs763361 is significantly associated with Argentinean CED (P = 0.0009, OR = 1.60).
|
20338887 |
2010 |
|
Celiac Disease
|
|
0.020 |
GeneticVariation
|
BEFREE |
To replicate this association in non-European populations, we evaluated case-control association between rs763361 and coeliac disease (CED) samples from Argentina; SLE, RA, type-1 diabetes (T1D) and primary SS (pSS) from Colombia; and SLE samples from China and Japan.
|
20338887 |
2010 |
|
Celiac Disease
|
|
0.020 |
GeneticVariation
|
BEFREE |
Recently, there has been increasing evidence shown that a non-synonymous exchange (Gly307Ser/rs763361) of the CD226 gene on chromosome 18q22 is linked to several autoimmune diseases (ADs) including type 1 diabetes (T1D), celiac disease (CED), rheumatoid arthritis (RA), multiple sclerosis (MS), Grave's disease, Wegener's granulomatosis (WG), psoriasis, and primary sicca syndrome (pSS).
|
23073294 |
2013 |
|
Diabetes Mellitus, Insulin-Dependent
|
|
0.900 |
GeneticVariation
|
BEFREE |
In addition to the analysis of newly available samples in T1D (2088 cases and 3289 controls) and autoimmune thyroid disease (AITD) (821 cases and 1920 controls), resulting in strong support for the Ser(307) association with T1D (P=3.46 x 10(-9)) and continued potential evidence for AITD (P=0.0345), we provide evidence for association of Gly307Ser with MS (P=4.20 x 10(-4)) and rheumatoid arthritis (RA) (P=0.017).
|
18971939 |
2009 |
|
Diabetes Mellitus, Insulin-Dependent
|
|
0.900 |
GeneticVariation
|
GWASCAT |
Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes.
|
17554260 |
2007 |
|
Diabetes Mellitus, Insulin-Dependent
|
|
0.900 |
GeneticVariation
|
BEFREE |
This meta-analysis demonstrates the CD226 rs763361 polymorphism confers susceptibility to autoimmune disease in Europeans, South Americans and Asians, and in particular, shows that the CD226 rs763361 polymorphism is associated with SLE, SSc and T1D.
|
22941566 |
2012 |
|
Diabetes Mellitus, Insulin-Dependent
|
|
0.900 |
GeneticVariation
|
BEFREE |
The rs763361 variant of CD226 gene (TT genotype) was associated with susceptibility to T1D and with the degree of aggressiveness of the disease in T1D patients from Brazil.Ancestry had no effect.
|
24891767 |
2014 |
|
Diabetes Mellitus, Insulin-Dependent
|
|
0.900 |
GeneticVariation
|
BEFREE |
The TT genotype [odds ratio (OR) = 2.29, 95% confidence interval (CI) = 1.25-4.18, P = 0.0071) and the T allele (OR = 1.48, 95% CI = 1.11-1.98, P = 0.0084) of the rs763361 SNP were associated with the risk of type 1 diabetes.
|
19624611 |
2009 |
|
Diabetes Mellitus, Insulin-Dependent
|
|
0.900 |
GeneticVariation
|
BEFREE |
Recently, there has been increasing evidence that a non-synonymous exchange (Gly307Ser) in the gene for CD226 is linked to several autoimmune diseases including type 1 diabetes, multiple sclerosis (MS), rheumatoid arthritis and Grave's disease.
|
19536154 |
2009 |