|
Lupus Erythematosus, Systemic
|
|
0.050 |
GeneticVariation
|
BEFREE |
A 3-variant haplotype, rs763361;rs34794968;rs727088 (ATC), in the last exon of CD226 was associated with SLE (P = 1.3 × 10(-4) , odds ratio 1.24, 95% confidence interval 1.11-1.38).
|
20669283 |
2010 |
|
Autoimmune Diseases
|
|
0.090 |
GeneticVariation
|
BEFREE |
A nonsynonymous polymorphism in exon 7 of the gene encoding the lymphocyte cell-surface CD226 (DNAM1) receptor, Gly307Ser (rs763361), has recently been identified as conferring risk to many autoimmune disorders.
|
21521299 |
2011 |
|
Autoimmune Diseases
|
|
0.090 |
GeneticVariation
|
BEFREE |
A novel non-synonymous (Gly307Ser) variant, rs763361, of the CD226 gene on chromosome 18q22 was recently shown to be associated with multiple autoimmune diseases.
|
20887380 |
2011 |
|
Systemic Scleroderma
|
|
0.040 |
GeneticVariation
|
BEFREE |
Among eight SSc-associated susceptibility polymorphisms which were applied for meta-analysis, IRF5 rs2004640 polymorphism (OR 1.12; 95% CI 1.02-1.22, P = 1.39 × 10<sup>-2</sup>), STAT4 rs7574865 polymorphism (OR 1.25; 95% CI 1.07-1.47, P = 5.3 × 10<sup>-3</sup>), IRAK1 rs1059702 polymorphism (OR 1.20; 95% CI 1.05-1.37, P = 0.007), and CTGF G-945C polymorphism (OR 1.42; 95% CI 1.18-1.71, P = 0.002) are associated with PF status in SSc, while TNFAIP3 rs5029939, CD226 rs763361, CD247 rs2056626, and IRF5 rs10488631 polymorphisms are not.
|
28434122 |
2017 |
|
Arthritis, Psoriatic
|
|
0.010 |
GeneticVariation
|
BEFREE |
An association of STAT4 (rs10181656) with PsA was confirmed whereas CD226 (rs763361) was associated with PsA but not with RA, in contrast to previous reports.
|
27440135 |
2017 |
|
Rheumatoid Arthritis
|
|
0.080 |
GeneticVariation
|
BEFREE |
An association of STAT4 (rs10181656) with PsA was confirmed whereas CD226 (rs763361) was associated with PsA but not with RA, in contrast to previous reports.
|
27440135 |
2017 |
|
Autoimmune Diseases
|
|
0.090 |
GeneticVariation
|
BEFREE |
CD226 Gly307Ser association with multiple autoimmune diseases.
|
18971939 |
2009 |
|
Primary sclerosing cholangitis
|
|
0.700 |
GeneticVariation
|
GWASDB |
Dense genotyping of immune-related disease regions identifies nine new risk loci for primary sclerosing cholangitis.
|
23603763 |
2013 |
|
Rheumatoid Arthritis
|
|
0.080 |
GeneticVariation
|
BEFREE |
Disease-specific meta-analysis showed an association between systemic lupus erythematosus (SLE) and the CD226 rs763361 T allele (OR 1.150, 95% CI 1.040-1.271, p = 0.006), but no association between rheumatoid arthritis and the CD226 rs763361 polymorphism (OR for the T allele 1.207, 95% CI 0.913-1.596, p = 0.187).
|
22941566 |
2012 |
|
Systemic Scleroderma
|
|
0.040 |
GeneticVariation
|
BEFREE |
Furthermore, association analysis of the genotypes with clinical manifestations of the disease revealed that rs763361 variants were associated with the forced vital capacity (FVC) in SSc patients.
|
29338153 |
2017 |
|
Diabetes Mellitus, Insulin-Dependent
|
|
0.900 |
GeneticVariation
|
GWASCAT |
Genome-wide association analysis of autoantibody positivity in type 1 diabetes cases.
|
21829393 |
2011 |
|
Autoantibody measurement
|
|
0.700 |
GeneticVariation
|
GWASDB |
Genome-wide association analysis of autoantibody positivity in type 1 diabetes cases.
|
21829393 |
2011 |
|
Multiple Sclerosis
|
|
0.770 |
GeneticVariation
|
GWASDB |
Genome-wide meta-analysis identifies novel multiple sclerosis susceptibility loci.
|
22190364 |
2011 |
|
Diabetes Mellitus, Insulin-Dependent
|
|
0.900 |
GeneticVariation
|
BEFREE |
In addition to the analysis of newly available samples in T1D (2088 cases and 3289 controls) and autoimmune thyroid disease (AITD) (821 cases and 1920 controls), resulting in strong support for the Ser(307) association with T1D (P=3.46 x 10(-9)) and continued potential evidence for AITD (P=0.0345), we provide evidence for association of Gly307Ser with MS (P=4.20 x 10(-4)) and rheumatoid arthritis (RA) (P=0.017).
|
18971939 |
2009 |
|
Autoimmune thyroid disease (AITD)
|
|
0.010 |
GeneticVariation
|
BEFREE |
In addition to the analysis of newly available samples in T1D (2088 cases and 3289 controls) and autoimmune thyroid disease (AITD) (821 cases and 1920 controls), resulting in strong support for the Ser(307) association with T1D (P=3.46 x 10(-9)) and continued potential evidence for AITD (P=0.0345), we provide evidence for association of Gly307Ser with MS (P=4.20 x 10(-4)) and rheumatoid arthritis (RA) (P=0.017).
|
18971939 |
2009 |
|
Multiple Sclerosis
|
|
0.770 |
GeneticVariation
|
BEFREE |
In addition to the analysis of newly available samples in T1D (2088 cases and 3289 controls) and autoimmune thyroid disease (AITD) (821 cases and 1920 controls), resulting in strong support for the Ser(307) association with T1D (P=3.46 x 10(-9)) and continued potential evidence for AITD (P=0.0345), we provide evidence for association of Gly307Ser with MS (P=4.20 x 10(-4)) and rheumatoid arthritis (RA) (P=0.017).
|
18971939 |
2009 |
|
Rheumatoid Arthritis
|
|
0.080 |
GeneticVariation
|
BEFREE |
In addition to the analysis of newly available samples in T1D (2088 cases and 3289 controls) and autoimmune thyroid disease (AITD) (821 cases and 1920 controls), resulting in strong support for the Ser(307) association with T1D (P=3.46 x 10(-9)) and continued potential evidence for AITD (P=0.0345), we provide evidence for association of Gly307Ser with MS (P=4.20 x 10(-4)) and rheumatoid arthritis (RA) (P=0.017).
|
18971939 |
2009 |
|
Diabetes Mellitus, Insulin-Dependent
|
|
0.900 |
GeneticVariation
|
BEFREE |
Meta-analyses for SLE (using our three populations) and T1D (our population and three published populations) yielded significant association with rs763361, P = 0.009 (OR = 1.16) and P = 1.1.46 x 10(-9) (OR = 1.14), respectively.
|
20338887 |
2010 |
|
Rheumatoid Arthritis
|
|
0.080 |
GeneticVariation
|
BEFREE |
Meta-analysis confirms the association between rs763361 and RA (overall P < 0.001, overall odds ratio = 1.12).
|
21286723 |
2012 |
|
Autoimmune Diseases
|
|
0.090 |
GeneticVariation
|
BEFREE |
Moreover, co-engagement of the TCR and a risk variant of CD226 that is associated with autoimmunity (rs763361) further enhanced VAV1 activation and IL-17 production.
|
29991650 |
2018 |
|
Giant Cell Arteritis
|
|
0.010 |
GeneticVariation
|
BEFREE |
No significant association between the CD226 polymorphisms and susceptibility to GCA was found (rs727088: p=0.92, OR=1.01, CI 95% 0.86-1.18; rs34794968: p=0.61, OR=1.04, CI 95% 0.89-1.22; rs763361: p=0.88, OR=0.99, CI 95% 0.84-1.16).
|
22512842 |
2012 |
|
Multiple Sclerosis
|
|
0.770 |
GeneticVariation
|
BEFREE |
Novel association of the CD226 (DNAM-1) Gly307Ser polymorphism in Wegener's granulomatosis and confirmation for multiple sclerosis in German patients.
|
19536154 |
2009 |
|
Rheumatoid Arthritis
|
|
0.080 |
GeneticVariation
|
BEFREE |
Our meta-analysis demonstrates that the CD226 rs763361 and FASL rs763110 polymorphisms are associated with RA, especially in Asians.
|
25645050 |
2015 |
|
Autoimmune Diseases
|
|
0.090 |
GeneticVariation
|
BEFREE |
Our results demonstrate that the coding variant rs763361 in CD226 gene is associated with multiple ADs in non-European populations.
|
20338887 |
2010 |
|
Lupus Erythematosus, Systemic
|
|
0.050 |
GeneticVariation
|
BEFREE |
Our results support an important association of rs4810485 in CD40 gene and rs76</span>3361 in CD226 gene polymorphism, combined effect of rs4810485 and rs763361 with increased risk of SLE.
|
27722794 |
2016 |