Diabetes Mellitus, Insulin-Dependent
|
|
0.900 |
GeneticVariation
|
BEFREE |
In addition to the analysis of newly available samples in T1D (2088 cases and 3289 controls) and autoimmune thyroid disease (AITD) (821 cases and 1920 controls), resulting in strong support for the Ser(307) association with T1D (P=3.46 x 10(-9)) and continued potential evidence for AITD (P=0.0345), we provide evidence for association of Gly307Ser with MS (P=4.20 x 10(-4)) and rheumatoid arthritis (RA) (P=0.017).
|
18971939 |
2009 |
Diabetes Mellitus, Insulin-Dependent
|
|
0.900 |
GeneticVariation
|
BEFREE |
This meta-analysis demonstrates the CD226 rs763361 polymorphism confers susceptibility to autoimmune disease in Europeans, South Americans and Asians, and in particular, shows that the CD226 rs763361 polymorphism is associated with SLE, SSc and T1D.
|
22941566 |
2012 |
Diabetes Mellitus, Insulin-Dependent
|
|
0.900 |
GeneticVariation
|
BEFREE |
The rs763361 variant of CD226 gene (TT genotype) was associated with susceptibility to T1D and with the degree of aggressiveness of the disease in T1D patients from Brazil.Ancestry had no effect.
|
24891767 |
2014 |
Diabetes Mellitus, Insulin-Dependent
|
|
0.900 |
GeneticVariation
|
BEFREE |
The TT genotype [odds ratio (OR) = 2.29, 95% confidence interval (CI) = 1.25-4.18, P = 0.0071) and the T allele (OR = 1.48, 95% CI = 1.11-1.98, P = 0.0084) of the rs763361 SNP were associated with the risk of type 1 diabetes.
|
19624611 |
2009 |
Diabetes Mellitus, Insulin-Dependent
|
|
0.900 |
GeneticVariation
|
BEFREE |
Recently, there has been increasing evidence that a non-synonymous exchange (Gly307Ser) in the gene for CD226 is linked to several autoimmune diseases including type 1 diabetes, multiple sclerosis (MS), rheumatoid arthritis and Grave's disease.
|
19536154 |
2009 |
Diabetes Mellitus, Insulin-Dependent
|
|
0.900 |
GeneticVariation
|
BEFREE |
The current study supports the rs6679677 (PHTF1-PTPN22), rs17696736 (C12orf30) and rs763361 (CD226) SNPs as susceptibility factors for type 1 diabetes outside the major histocompatibility region (MHC) region.
|
20089178 |
2010 |
Diabetes Mellitus, Insulin-Dependent
|
|
0.900 |
GeneticVariation
|
BEFREE |
We replicated the genetic association with rs13277113 (p = 0.0009, OR 1.46) and rs2736340 (p = 0.0001, OR 1.63) from C8orf13-BLK (8p23.1, associated with RA and systemic lupus erythematosus), and rs763361 (p = 0.03) from CD226 (18q22.3, associated with multiple sclerosis and type 1 diabetes) in the Colombian population.
|
21765104 |
2011 |
Diabetes Mellitus, Insulin-Dependent
|
|
0.900 |
GeneticVariation
|
BEFREE |
Recently, there has been increasing evidence shown that a non-synonymous exchange (Gly307Ser/rs763361) of the CD226 gene on chromosome 18q22 is linked to several autoimmune diseases (ADs) including type 1 diabetes (T1D), celiac disease (CED), rheumatoid arthritis (RA), multiple sclerosis (MS), Grave's disease, Wegener's granulomatosis (WG), psoriasis, and primary sicca syndrome (pSS).
|
23073294 |
2013 |
Diabetes Mellitus, Insulin-Dependent
|
|
0.900 |
GeneticVariation
|
BEFREE |
These findings revealed that CD226 rs763361 polymorphism was significantly associated with susceptibility to T1D and that the presence of the T allele might be a genetic factor for susceptibility to T1D.
|
26634488 |
2015 |
Diabetes Mellitus, Insulin-Dependent
|
|
0.900 |
GeneticVariation
|
BEFREE |
Meta-analyses for SLE (using our three populations) and T1D (our population and three published populations) yielded significant association with rs763361, P = 0.009 (OR = 1.16) and P = 1.1.46 x 10(-9) (OR = 1.14), respectively.
|
20338887 |
2010 |
Multiple Sclerosis
|
|
0.770 |
GeneticVariation
|
BEFREE |
Novel association of the CD226 (DNAM-1) Gly307Ser polymorphism in Wegener's granulomatosis and confirmation for multiple sclerosis in German patients.
|
19536154 |
2009 |
Multiple Sclerosis
|
|
0.770 |
GeneticVariation
|
BEFREE |
Recently, there has been increasing evidence shown that a non-synonymous exchange (Gly307Ser/rs763361) of the CD226 gene on chromosome 18q22 is linked to several autoimmune diseases (ADs) including type 1 diabetes (T1D), celiac disease (CED), rheumatoid arthritis (RA), multiple sclerosis (MS), Grave's disease, Wegener's granulomatosis (WG), psoriasis, and primary sicca syndrome (pSS).
|
23073294 |
2013 |
Multiple Sclerosis
|
|
0.770 |
GeneticVariation
|
BEFREE |
Three SNPs were found to be associated with MS: rs1678542 in KIF5A (P=0.001, odds ratio (OR)=1.13, 95% confidence interval (CI)=1.05-1.23); rs3184504 in SH2B3 (P=0.00001, OR=1.19, 95% CI=1.10-1.27) and rs763361 in CD226 (P=0.00007, OR=1.16, 95%CI=1.08-1.25).
|
20508602 |
2010 |
Multiple Sclerosis
|
|
0.770 |
GeneticVariation
|
BEFREE |
The goal of the current study was to investigate the association of single nucleotide polymorphisms (SNP) with the immunologically related genes responsible for the disease, composed of CD58 (rs2300747 A>G), CD226 (rs763361 C>T), and HLA-G (rs1611715 A>C), with MS susceptibility.
|
30128676 |
2018 |
Multiple Sclerosis
|
|
0.770 |
GeneticVariation
|
BEFREE |
Two other SNPs were nominally associated with MS in this dataset, namely CLEC16A rs 12708716 (p = 0.0082, OR = 1.478, 95% CI = 1.106-1.975) and CD226 rs763361 (p = 0.03971, OR = 1.353, CI = 1.014-1.805).
|
20952449 |
2011 |
Multiple Sclerosis
|
|
0.770 |
GeneticVariation
|
BEFREE |
In addition to the analysis of newly available samples in T1D (2088 cases and 3289 controls) and autoimmune thyroid disease (AITD) (821 cases and 1920 controls), resulting in strong support for the Ser(307) association with T1D (P=3.46 x 10(-9)) and continued potential evidence for AITD (P=0.0345), we provide evidence for association of Gly307Ser with MS (P=4.20 x 10(-4)) and rheumatoid arthritis (RA) (P=0.017).
|
18971939 |
2009 |
Multiple Sclerosis
|
|
0.770 |
GeneticVariation
|
BEFREE |
We replicated the genetic association with rs13277113 (p = 0.0009, OR 1.46) and rs2736340 (p = 0.0001, OR 1.63) from C8orf13-BLK (8p23.1, associated with RA and systemic lupus erythematosus), and rs763361 (p = 0.03) from CD226 (18q22.3, associated with multiple sclerosis and type 1 diabetes) in the Colombian population.
|
21765104 |
2011 |
Autoimmune Diseases
|
|
0.090 |
GeneticVariation
|
BEFREE |
Our results demonstrate that the coding variant rs763361 in CD226 gene is associated with multiple ADs in non-European populations.
|
20338887 |
2010 |
Autoimmune Diseases
|
|
0.090 |
GeneticVariation
|
BEFREE |
This meta-analysis provided evidence that CD226 Gly307Ser (rs763361) is significantly associated with the risk of multiple autoimmune diseases.
|
23073294 |
2013 |
Autoimmune Diseases
|
|
0.090 |
GeneticVariation
|
BEFREE |
CD226 Gly307Ser association with multiple autoimmune diseases.
|
18971939 |
2009 |
Autoimmune Diseases
|
|
0.090 |
GeneticVariation
|
BEFREE |
This meta-analysis demonstrates the CD226 rs763361 polymorphism confers susceptibility to autoimmune disease in Europeans, South Americans and Asians, and in particular, shows that the CD226 rs763361 polymorphism is associated with SLE, SSc and T1D.
|
22941566 |
2012 |
Autoimmune Diseases
|
|
0.090 |
GeneticVariation
|
BEFREE |
A novel non-synonymous (Gly307Ser) variant, rs763361, of the CD226 gene on chromosome 18q22 was recently shown to be associated with multiple autoimmune diseases.
|
20887380 |
2011 |
Autoimmune Diseases
|
|
0.090 |
GeneticVariation
|
BEFREE |
Moreover, co-engagement of the TCR and a risk variant of CD226 that is associated with autoimmunity (rs763361) further enhanced VAV1 activation and IL-17 production.
|
29991650 |
2018 |
Autoimmune Diseases
|
|
0.090 |
GeneticVariation
|
BEFREE |
The nonsynonymous polymorphism rs763361 of the CD226 gene, which encodes DNAX accessory molecule 1, which is involved in T cell costimulation pathways, has recently been identified as a genetic risk factor for autoimmunity.
|
21162102 |
2011 |
Autoimmune Diseases
|
|
0.090 |
GeneticVariation
|
BEFREE |
A nonsynonymous polymorphism in exon 7 of the gene encoding the lymphocyte cell-surface CD226 (DNAM1) receptor, Gly307Ser (rs763361), has recently been identified as conferring risk to many autoimmune disorders.
|
21521299 |
2011 |