Source: ANIMAL_MODELS

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 4842
Gene Symbol: NOS1
NOS1
CUI: C0007786
Disease: Brain Ischemia
Brain Ischemia
0.210 Biomarker RGD Hydrogen supplemented air inhalation reduces changes of prooxidant enzyme and gap junction protein levels after transient global cerebral ischemia in the rat hippocampus. 21718970

2011

Entrez Id: 2100
Gene Symbol: ESR2
ESR2
CUI: C0007786
Disease: Brain Ischemia
Brain Ischemia
0.210 Biomarker RGD Estradiol modulates bcl-2 in cerebral ischemia: a potential role for estrogen receptors. 10414967

1999

Entrez Id: 6529
Gene Symbol: SLC6A1
SLC6A1
CUI: C0007786
Disease: Brain Ischemia
Brain Ischemia
0.210 Biomarker RGD Sequential release of GABA by exocytosis and reversed uptake leads to neuronal swelling in simulated ischemia of hippocampal slices. 15084665

2004

Entrez Id: 6387
Gene Symbol: CXCL12
CXCL12
CUI: C0007786
Disease: Brain Ischemia
Brain Ischemia
0.210 Biomarker RGD SDF-1alpha/CXCR4-mediated migration of systemically transplanted bone marrow stromal cells towards ischemic brain lesion in a rat model. 18206136

2008

Entrez Id: 5578
Gene Symbol: PRKCA
PRKCA
CUI: C0007786
Disease: Brain Ischemia
Brain Ischemia
0.210 Biomarker RGD Subtype activation and interaction of protein kinase C and mitogen-activated protein kinase controlling receptor expression in cerebral arteries and microvessels after subarachnoid hemorrhage. 18032736

2008

Entrez Id: 6547
Gene Symbol: SLC8A3
SLC8A3
CUI: C0007786
Disease: Brain Ischemia
Brain Ischemia
0.210 Biomarker RGD Permanent focal brain ischemia induces isoform-dependent changes in the pattern of Na+/Ca2+ exchanger gene expression in the ischemic core, periinfarct area, and intact brain regions. 16107787

2006

Entrez Id: 4891
Gene Symbol: SLC11A2
SLC11A2
CUI: C0007786
Disease: Brain Ischemia
Brain Ischemia
0.210 Biomarker RGD Tanshinone IIA prevented brain iron dyshomeostasis in cerebral ischemic rats. 21325818

2011

Entrez Id: 8678
Gene Symbol: BECN1
BECN1
CUI: C0007786
Disease: Brain Ischemia
Brain Ischemia
0.210 Biomarker RGD RNA interference-mediated downregulation of Beclin1 attenuates cerebral ischemic injury in rats. 19574998

2009

Entrez Id: 54207
Gene Symbol: KCNK10
KCNK10
CUI: C0007786
Disease: Brain Ischemia
Brain Ischemia
0.210 Biomarker RGD Enhanced expressions of arachidonic acid-sensitive tandem-pore domain potassium channels in rat experimental acute cerebral ischemia. 15652517

2005

Entrez Id: 3776
Gene Symbol: KCNK2
KCNK2
CUI: C0007786
Disease: Brain Ischemia
Brain Ischemia
0.210 Biomarker RGD Alterations in the expression of lipid and mechano-gated two-pore domain potassium channel genes in rat brain following chronic cerebral ischemia. 14741413

2004

Entrez Id: 8678
Gene Symbol: BECN1
BECN1
CUI: C0007786
Disease: Brain Ischemia
Brain Ischemia
0.210 Biomarker RGD Focal cerebral ischemia induces upregulation of Beclin 1 and autophagy-like cell death. 17936001

2008

Entrez Id: 718
Gene Symbol: C3
C3
CUI: C0007786
Disease: Brain Ischemia
Brain Ischemia
0.210 Biomarker RGD Complement activation contributes to hypoxic-ischemic brain injury in neonatal rats. 14561876

2003

Entrez Id: 1234
Gene Symbol: CCR5
CCR5
CUI: C0007786
Disease: Brain Ischemia
Brain Ischemia
0.210 Biomarker RGD Cloning of rat HIV-1-chemokine coreceptor CKR5 from microglia and upregulation of its mRNA in ischemic and endotoxinemic rat brain. 9670989

1998

Entrez Id: 7276
Gene Symbol: TTR
TTR
CUI: C0007786
Disease: Brain Ischemia
Brain Ischemia
0.210 Biomarker RGD Combined proteomic approach with SELDI-TOF-MS and peptide mass fingerprinting identified the rapid increase of monomeric transthyretin in rat cerebrospinal fluid after transient focal cerebral ischemia. 15469881

2004

Entrez Id: 6543
Gene Symbol: SLC8A2
SLC8A2
CUI: C0007786
Disease: Brain Ischemia
Brain Ischemia
0.210 Biomarker RGD Permanent focal brain ischemia induces isoform-dependent changes in the pattern of Na+/Ca2+ exchanger gene expression in the ischemic core, periinfarct area, and intact brain regions. 16107787

2006

Entrez Id: 4842
Gene Symbol: NOS1
NOS1
CUI: C0007786
Disease: Brain Ischemia
Brain Ischemia
0.210 Biomarker RGD Early and sharp nitric oxide production and anoxic depolarization in the rat hippocampus during transient forebrain ischemia. 17451676

2007

Entrez Id: 1020
Gene Symbol: CDK5
CDK5
CUI: C0007786
Disease: Brain Ischemia
Brain Ischemia
0.210 Biomarker RGD Cdk5 activation induces hippocampal CA1 cell death by directly phosphorylating NMDA receptors. 14502288

2003

Entrez Id: 1191
Gene Symbol: CLU
CLU
CUI: C0007786
Disease: Brain Ischemia
Brain Ischemia
0.210 Biomarker RGD Delayed, but prolonged increases in astrocytic clusterin (ApoJ) mRNA expression following acute cortical spreading depression in the rat: evidence for a role of clusterin in ischemic tolerance. 12782389

2003

Entrez Id: 240
Gene Symbol: ALOX5
ALOX5
CUI: C0007786
Disease: Brain Ischemia
Brain Ischemia
0.210 Biomarker RGD Zileuton reduces inflammatory reaction and brain damage following permanent cerebral ischemia in rats. 20204486

2010

Entrez Id: 285
Gene Symbol: ANGPT2
ANGPT2
CUI: C0007786
Disease: Brain Ischemia
Brain Ischemia
0.210 Biomarker RGD The effect of recombinant human erythropoietin on neurovasculature repair after focal ischemic stroke in neonatal rats. 17494864

2007

Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
CUI: C0007786
Disease: Brain Ischemia
Brain Ischemia
0.200 Biomarker RGD Lesion-associated expression of transforming growth factor-beta-2 in the rat nervous system: evidence for down-regulating the phagocytic activity of microglia and macrophages. 14997937

2004

Entrez Id: 5566
Gene Symbol: PRKACA
PRKACA
CUI: C0007786
Disease: Brain Ischemia
Brain Ischemia
0.200 Biomarker RGD Impairment of cerebral cAMP-mediated signal transduction system and of spatial memory function after microsphere embolism in rats. 12150772

2002

Entrez Id: 831
Gene Symbol: CAST
CAST
CUI: C0007786
Disease: Brain Ischemia
Brain Ischemia
0.200 Biomarker RGD 3-[2-[4-(3-Chloro-2-methylphenylmethyl)-1-piperazinyl]ethyl]-5,6-dimethoxy-1-(4-imidazolylmethyl)-1H-indazole dihydro-chloride 3.5 hydrate (DY-9760e) is neuroprotective in rat microsphere embolism: role of the cross-talk between calpain and caspase-3 through calpastatin. 16467455

2006

Entrez Id: 2149
Gene Symbol: F2R
F2R
CUI: C0007786
Disease: Brain Ischemia
Brain Ischemia
0.200 Biomarker RGD Taken together, these data suggest involvement of the thrombin receptors PAR-1, PAR-3, and PAR-4 in the pathophysiology of brain ischemia. 14705148

2004

Entrez Id: 5580
Gene Symbol: PRKCD
PRKCD
CUI: C0007786
Disease: Brain Ischemia
Brain Ischemia
0.200 Biomarker RGD DeltaPKC mediates microcerebrovascular dysfunction in acute ischemia and in chronic hypertensive stress in vivo. 17350602

2007