×
Entrez Id: 1395
Gene Symbol: CRHR2
CRHR2
Mental Depression
0.520
Biomarker
RGD
Alterations in the central CRF system of two different rat models of comorbid depression and functional gastrointestinal disorders.
20860876 2011
×
Entrez Id: 1393
Gene Symbol: CRHBP
CRHBP
Mental Depression
0.520
Biomarker
RGD
Icariin attenuates chronic mild stress-induced dysregulation of the LHPA stress circuit in rats.
19631474 2010
×
Entrez Id: 84152
Gene Symbol: PPP1R1B
PPP1R1B
Mental Depression
0.510
Therapeutic
RGD
PPARα modulation of mesolimbic dopamine transmission rescues depression-related behaviors.
27457507 2016
×
Entrez Id: 3570
Gene Symbol: IL6R
IL6R
Mental Depression
0.510
Biomarker
RGD
Exogenous interleukin-6 facilitated the contraction of the colon in a depression rat model.
23589140 2013
×
Entrez Id: 7054
Gene Symbol: TH
TH
Mental Depression
0.500
Biomarker
RGD
The results indicate that there exists possible interrelation between TH and TPH gene expression and epigenetic histone acetylation in CUS-induced depressive rats, which at least partly contributes to the etiology of depression .
24495952 2014
×
Entrez Id: 10014
Gene Symbol: HDAC5
HDAC5
Mental Depression
0.500
Biomarker
RGD
Administration of sodium valproate (VPA), a histone deacetylase 5 (HDAC5 ) inhibitor, not only significantly relieved the anxiety- and depression -like behaviors of CUS-induced rats but also clearly blunted decrease of H3(K9) and H4(K12) acetylation and expression of TH and TPH, and prevented increase of HDAC5 expression.
24495952 2014
×
Entrez Id: 5144
Gene Symbol: PDE4D
PDE4D
Mental Depression
0.500
Biomarker
RGD
The rat model confirms Pde4d 's role in depression but not in spatial learning or memory enhancement and shows for the first time higher fear conditioning and altered extinction compared with controls.
22487514 2012
×
Entrez Id: 6622
Gene Symbol: SNCA
SNCA
Mental Depression
0.300
Biomarker
RGD
Here we sought to determine if alpha-Syn , or the other synuclein family members, beta-synuclein (beta-Syn) and gamma-synuclein (gamma-Syn), modulate NET activity in an animal model of depression , the Wistar-Kyoto (WKY) rat.
18800064 2009
×
Entrez Id: 4842
Gene Symbol: NOS1
NOS1
Mental Depression
0.270
Therapeutic
RGD
[Antidepressant effect of microinjection of neuropeptide Y into the hippocampus is mediated by decreased expression of nitric oxide synthase].
20571741 2010
×
Entrez Id: 2100
Gene Symbol: ESR2
ESR2
Mental Depression
0.250
Therapeutic
RGD
Estradiol decreases rat depressive behavior by estrogen receptor beta but not alpha: no correlation with plasma corticosterone.
24128867 2014
×
Entrez Id: 9722
Gene Symbol: NOS1AP
NOS1AP
Mental Depression
0.220
Therapeutic
RGD
Some molecular effectors of antidepressant action of quetiapine revealed by DNA microarray in the frontal cortex of anhedonic rats.
19587612 2009
×
Entrez Id: 553
Gene Symbol: AVPR1B
AVPR1B
Mental Depression
0.210
Therapeutic
RGD
Vasopressin V1B receptor antagonists may be effective for the treatment of depression and anxiety and the objective of this study was to characterize the pharmacological profiles of two newly synthesized arginine vasopressin receptor 1B (V1B receptor) antagonists, TASP0233278 and TASP0390325.24654684 2014
×
Entrez Id: 4887
Gene Symbol: NPY2R
NPY2R
Mental Depression
0.210
Therapeutic
RGD
Role of neuropeptide Y Y₁ and Y₂ receptors on behavioral despair in a rat model of depression with co-morbid anxiety.
21803058 2012
×
Entrez Id: 1020
Gene Symbol: CDK5
CDK5
Mental Depression
0.210
Therapeutic
RGD
Increased Cdk5/p35 activity in the dentate gyrus mediates depressive-like behaviour in rats.
21682945 2012
×
Entrez Id: 7381
Gene Symbol: UQCRB
UQCRB
Mental Depression
0.210
Biomarker
RGD
Candidate hippocampal biomarkers of susceptibility and resilience to stress in a rat model of depression.
22311638 2012
×
Entrez Id: 581
Gene Symbol: BAX
BAX
Mental Depression
0.210
Therapeutic
RGD
Venlafaxine modulates depression-induced behaviour and the expression of Bax mRNA and Bcl-xl mRNA in both hippocampus and myocardium.
21308783 2011
×
Entrez Id: 5074
Gene Symbol: PAWR
PAWR
Mental Depression
0.210
Biomarker
RGD
Importantly, Par-4 and DRD2 mRNA levels significantly correlated with depression -like behaviors.
21596067 2011
×
Entrez Id: 1571
Gene Symbol: CYP2E1
CYP2E1
Mental Depression
0.210
Biomarker
RGD
Hepatic drug metabolizing profile of Flinders Sensitive Line rat model of depression.
20595028 2010
×
Entrez Id: 1564
Gene Symbol: CYP2D7
CYP2D7
Mental Depression
0.210
Biomarker
RGD
Hepatic drug metabolizing profile of Flinders Sensitive Line rat model of depression.
20595028 2010
×
Entrez Id: 4747
Gene Symbol: NEFL
NEFL
Mental Depression
0.210
Biomarker
RGD
Cytoskeleton of hippocampal neurons as a target for valproic acid in an experimental model of depression.
17683840 2007
×
Entrez Id: 1728
Gene Symbol: NQO1
NQO1
Mental Depression
0.200
Therapeutic
RGD
Insights into the potential antidepressant mechanisms of cilostazol in chronically restraint rats: impact on the Nrf2 pathway.
28763303 2018
×
Entrez Id: 8564
Gene Symbol: KMO
KMO
Mental Depression
0.200
Biomarker
RGD
Regulation of the kynurenine metabolism pathway by Xiaoyao San and the underlying effect in the hippocampus of the depressed rat.
29217494 2018
×
Entrez Id: 8772
Gene Symbol: FADD
FADD
Mental Depression
0.200
Therapeutic
RGD
Improved age-related deficits in cognitive performance and affective-like behavior following acute, but not repeated, 8-OH-DPAT treatments in rats: regulation of hippocampal FADD.
30138765 2018
×
Entrez Id: 10476
Gene Symbol: ATP5PD
ATP5PD
Mental Depression
0.200
Therapeutic
RGD
Differential proteomic analysis of the anti-depressive effects of oleamide in a rat chronic mild stress model of depression.
25641667 2015
×
Entrez Id: 4886
Gene Symbol: NPY1R
NPY1R
Mental Depression
0.200
Therapeutic
RGD
Role of neuropeptide Y Y₁ and Y₂ receptors on behavioral despair in a rat model of depression with co-morbid anxiety.
21803058 2012