Source: CURATED

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0023449
Disease: Acute lymphocytic leukemia
Acute lymphocytic leukemia 		0.400 Biomarker GENOMICS_ENGLAND Biallelic loss of CDKN2A is associated with poor response to treatment in pediatric acute lymphoblastic leukemia. 27756164

2017
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0001418
Disease: Adenocarcinoma
Adenocarcinoma 		0.400 Biomarker CTD_human Implication of p16 inactivation in tumorigenic activity of respiratory epithelial cell lines and adenocarcinoma cell line established from plutonium-induced lung tumor in rat. 20135361

2010
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0279628
Disease: Adenocarcinoma Of Esophagus
Adenocarcinoma Of Esophagus 		0.400 Biomarker CTD_human Exome and whole-genome sequencing of esophageal adenocarcinoma identifies recurrent driver events and mutational complexity. 23525077

2013
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0205641
Disease: Adenocarcinoma, Basal Cell
Adenocarcinoma, Basal Cell 		0.300 Biomarker CTD_human Implication of p16 inactivation in tumorigenic activity of respiratory epithelial cell lines and adenocarcinoma cell line established from plutonium-induced lung tumor in rat. 20135361

2010
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0205642
Disease: Adenocarcinoma, Oxyphilic
Adenocarcinoma, Oxyphilic 		0.300 Biomarker CTD_human Implication of p16 inactivation in tumorigenic activity of respiratory epithelial cell lines and adenocarcinoma cell line established from plutonium-induced lung tumor in rat. 20135361

2010
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0205645
Disease: Adenocarcinoma, Tubular
Adenocarcinoma, Tubular 		0.300 Biomarker CTD_human Implication of p16 inactivation in tumorigenic activity of respiratory epithelial cell lines and adenocarcinoma cell line established from plutonium-induced lung tumor in rat. 20135361

2010
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0750887
Disease: Adrenal Cancer
Adrenal Cancer 		0.300 Biomarker CTD_human Recurrent activating mutation in PRKACA in cortisol-producing adrenal tumors. 24747643

2014
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0001624
Disease: Adrenal Gland Neoplasms
Adrenal Gland Neoplasms 		0.300 Biomarker CTD_human Recurrent activating mutation in PRKACA in cortisol-producing adrenal tumors. 24747643

2014
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0206686
Disease: Adrenocortical carcinoma
Adrenocortical carcinoma 		0.310 Biomarker CTD_human Integrated genomic characterization of adrenocortical carcinoma. 24747642

2014
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0751606
Disease: Adult Acute Lymphocytic Leukemia
Adult Acute Lymphocytic Leukemia 		0.400 Biomarker GENOMICS_ENGLAND Biallelic loss of CDKN2A is associated with poor response to treatment in pediatric acute lymphoblastic leukemia. 27756164

2017
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0086692
Disease: Benign Neoplasm
Benign Neoplasm 		0.380 Biomarker CTD_human Activated TNF-alpha/NF-kappaB signaling via down-regulation of Fas-associated factor 1 in asbestos-induced mesotheliomas from Arf knockout mice. 19223589

2009
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0086692
Disease: Benign Neoplasm
Benign Neoplasm 		0.380 Biomarker CTD_human Loss of p16Ink4a with retention of p19Arf predisposes mice to tumorigenesis. 11544531

2001
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0496899
Disease: Benign neoplasm of brain, unspecified
Benign neoplasm of brain, unspecified 		0.300 Biomarker CTD_human Evaluation of genetic alterations in cancer-related genes in lung and brain tumors from B6C3F1 mice exposed to 1,3-butadiene or chloroprene. 16860786

2007
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0496899
Disease: Benign neoplasm of brain, unspecified
Benign neoplasm of brain, unspecified 		0.300 Biomarker CTD_human [p16 protein expression in the transplacental induced brain tumor in rat]. 15144691

2004
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0347284
Disease: Benign tumor of pancreas
Benign tumor of pancreas 		0.300 CausalMutation CGI

Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0347284
Disease: Benign tumor of pancreas
Benign tumor of pancreas 		0.300 GenomicAlterations CGI

Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0005426
Disease: Biliary Tract Neoplasm
Biliary Tract Neoplasm 		0.300 GeneticVariation UNIPROT

Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0005695
Disease: Bladder Neoplasm
Bladder Neoplasm 		0.600 Therapeutic CTD_human Effect of Ad-p16 combined with CDDP or As2O3 on human bladder cancer cells. 12973940

2003
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0005695
Disease: Bladder Neoplasm
Bladder Neoplasm 		0.600 Therapeutic CTD_human We, therefore, examined, in a population-based study of human bladder cancer, the relationship between epigenetic silencing of three tumor suppressor genes, p16(INK4A), RASSF1A and PRSS3, and exposure to both tobacco and arsenic in bladder cancer. 15987713

2006
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0005695
Disease: Bladder Neoplasm
Bladder Neoplasm 		0.600 GeneticVariation UNIPROT

Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0005695
Disease: Bladder Neoplasm
Bladder Neoplasm 		0.600 Biomarker CTD_human Effect of Ad-p16 combined with CDDP or As2O3 on human bladder cancer cells. 12973940

2003
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0005695
Disease: Bladder Neoplasm
Bladder Neoplasm 		0.600 Biomarker CTD_human We, therefore, examined, in a population-based study of human bladder cancer, the relationship between epigenetic silencing of three tumor suppressor genes, p16(INK4A), RASSF1A and PRSS3, and exposure to both tobacco and arsenic in bladder cancer. 15987713

2006
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0005940
Disease: Bone Diseases
Bone Diseases 		0.300 Biomarker CTD_human Aberrant methylation-induced dysfunction of p16 is associated with osteoblast activation caused by fluoride. 30259626

2019
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0006118
Disease: Brain Neoplasms
Brain Neoplasms 		0.400 Biomarker CTD_human To study in series the p16 protein expression on the rat brain tumor induced transplacentally by ENU. 15144691

2004
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0006118
Disease: Brain Neoplasms
Brain Neoplasms 		0.400 Biomarker CTD_human Evaluation of genetic alterations in cancer-related genes in lung and brain tumors from B6C3F1 mice exposed to 1,3-butadiene or chloroprene. 16860786

2007