Source: CURATED

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0014859
Disease: Esophageal Neoplasms
Esophageal Neoplasms 		0.800 Biomarker CTD_human Progressive silencing of p14ARF in oesophageal adenocarcinoma. 18410530

2009
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0014859
Disease: Esophageal Neoplasms
Esophageal Neoplasms 		0.800 GeneticVariation UNIPROT

Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms 		0.800 Biomarker CTD_human DNA methylation markers and early recurrence in stage I lung cancer. 18337602

2008
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms 		0.800 Biomarker CTD_human Aberrant methylation of the CDKN2a/p16INK4a gene promoter region in preinvasive bronchial lesions: a prospective study in high-risk patients without invasive cancer. 12115568

2002
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms 		0.800 GeneticVariation UNIPROT

Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms 		0.800 Biomarker CTD_human Methylation of the p16 and ER genes was very common (80 and 50%, respectively) in beryllium-induced lung tumors; both genes were methylated in 40% of the tumors. 11872642

2002
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms 		0.800 Biomarker CTD_human Implication of p16 inactivation in tumorigenic activity of respiratory epithelial cell lines and adenocarcinoma cell line established from plutonium-induced lung tumor in rat. 20135361

2010
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0025202
Disease: melanoma
melanoma 		0.800 GeneticVariation UNIPROT

Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0025202
Disease: melanoma
melanoma 		0.800 GenomicAlterations CGI

Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0025202
Disease: melanoma
melanoma 		0.800 Biomarker CTD_human Genetic alterations driving metastatic colony formation are acquired outside of the primary tumour in melanoma. 29426936

2018
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0025202
Disease: melanoma
melanoma 		0.800 Biomarker CTD_human In 47 melanoma cell lines homozygous loss, methylation or mutation of CDKN2A gene or loss of protein (p16(INK) (4A) ) predicted sensitivity to the CDK4/6 inhibitor PD0332991, while RB1 loss predicted resistance. 24495407

2014
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0025202
Disease: melanoma
melanoma 		0.800 CausalMutation CGI

Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0025202
Disease: melanoma
melanoma 		0.800 Biomarker GENOMICS_ENGLAND

Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0030297
Disease: Pancreatic Neoplasm
Pancreatic Neoplasm 		0.800 GeneticVariation UNIPROT

Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0030297
Disease: Pancreatic Neoplasm
Pancreatic Neoplasm 		0.800 Biomarker CTD_human Common variation at 2p13.3, 3q29, 7p13 and 17q25.1 associated with susceptibility to pancreatic cancer. 26098869

2015
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0030297
Disease: Pancreatic Neoplasm
Pancreatic Neoplasm 		0.800 GenomicAlterations CGI

Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0030297
Disease: Pancreatic Neoplasm
Pancreatic Neoplasm 		0.800 Biomarker CTD_human Novel germline p16(INK4) allele (Asp145Cys) in a family with multiple pancreatic carcinomas. Mutations in brief no. 148. Online. 10627132

1998
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0030297
Disease: Pancreatic Neoplasm
Pancreatic Neoplasm 		0.800 CausalMutation CGI

Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma 		0.700 GeneticVariation UNIPROT

Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma 		0.700 Biomarker CTD_human Functional kinomics identifies candidate therapeutic targets in head and neck cancer. 25125259

2014
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0151779
Disease: Cutaneous Melanoma
Cutaneous Melanoma 		0.700 Biomarker CTD_human A novel recurrent mutation in MITF predisposes to familial and sporadic melanoma. 22080950

2011
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0151779
Disease: Cutaneous Melanoma
Cutaneous Melanoma 		0.700 CausalMutation CGI

Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0151779
Disease: Cutaneous Melanoma
Cutaneous Melanoma 		0.700 GenomicAlterations CGI

Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C1835044
Disease: MELANOMA, CUTANEOUS MALIGNANT, SUSCEPTIBILITY TO, 2
MELANOMA, CUTANEOUS MALIGNANT, SUSCEPTIBILITY TO, 2 		0.700 GeneticVariation UNIPROT Prevalence of p16 and CDK4 germline mutations in 48 melanoma-prone families in France. The French Familial Melanoma Study Group. 9425228

1998
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C1835044
Disease: MELANOMA, CUTANEOUS MALIGNANT, SUSCEPTIBILITY TO, 2
MELANOMA, CUTANEOUS MALIGNANT, SUSCEPTIBILITY TO, 2 		0.700 GeneticVariation UNIPROT Five novel somatic CDKN2/p16 mutations identified in melanoma, glioma and carcinoma of the pancreas. Mutations in brief no. 170. Online. 10651484

1998