Source: CURATED

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0005940
Disease: Bone Diseases
Bone Diseases 		0.300 Biomarker CTD_human Aberrant methylation-induced dysfunction of p16 is associated with osteoblast activation caused by fluoride. 30259626

2019
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0016325
Disease: Fluoride Poisoning
Fluoride Poisoning 		0.300 Biomarker CTD_human These results reveal a regulatory role of p16 gene methylation on osteoblasts activation during the development of skeletal fluorosis. 30259626

2019
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C1449861
Disease: Micronuclei, Chromosome-Defective
Micronuclei, Chromosome-Defective 		0.300 Biomarker CTD_human Associations between DNA methylation in DNA damage response-related genes and cytokinesis-block micronucleus cytome index in diesel engine exhaust-exposed workers. 26410583

2016
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C1449862
Disease: Micronuclei, Genotoxicant-Induced
Micronuclei, Genotoxicant-Induced 		0.300 Biomarker CTD_human Associations between DNA methylation in DNA damage response-related genes and cytokinesis-block micronucleus cytome index in diesel engine exhaust-exposed workers. 26410583

2016
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0376407
Disease: Granulomatous Slack Skin
Granulomatous Slack Skin 		0.300 Biomarker CTD_human Genomic landscape of cutaneous T cell lymphoma. 26192916

2015
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0001624
Disease: Adrenal Gland Neoplasms
Adrenal Gland Neoplasms 		0.300 Biomarker CTD_human Recurrent activating mutation in PRKACA in cortisol-producing adrenal tumors. 24747643

2014
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0027626
Disease: Neoplasm Invasiveness
Neoplasm Invasiveness 		0.300 Biomarker CTD_human Loss of CDKN2A expression is a frequent event in primary invasive melanoma and correlates with sensitivity to the CDK4/6 inhibitor PD0332991 in melanoma cell lines. 24495407

2014
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0282313
Disease: Condition, Preneoplastic
Condition, Preneoplastic 		0.300 Biomarker CTD_human Promoter region hypermethylation and mRNA expression of MGMT and p16 genes in tissue and blood samples of human premalignant oral lesions and oral squamous cell carcinoma. 24991542

2014
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0750887
Disease: Adrenal Cancer
Adrenal Cancer 		0.300 Biomarker CTD_human Recurrent activating mutation in PRKACA in cortisol-producing adrenal tumors. 24747643

2014
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0751691
Disease: Perineurioma
Perineurioma 		0.300 Biomarker CTD_human PRC2 is recurrently inactivated through EED or SUZ12 loss in malignant peripheral nerve sheath tumors. 25240281

2014
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression 		0.300 Biomarker PSYGENET We have also quantified the mRNA of six genes previously identified as markers of the biopsychological stress associated with major depression: FOS, DUSP1, OGG1, STMN1, p16(INK4a) and TERT. 23668904

2013
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0677866
Disease: Brain Stem Neoplasms
Brain Stem Neoplasms 		0.300 Biomarker CTD_human PD-0332991, a CDK4/6 inhibitor, significantly prolongs survival in a genetically engineered mouse model of brainstem glioma. 24098593

2013
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0751886
Disease: Brain Stem Neoplasms, Primary
Brain Stem Neoplasms, Primary 		0.300 Biomarker CTD_human PD-0332991, a CDK4/6 inhibitor, significantly prolongs survival in a genetically engineered mouse model of brainstem glioma. 24098593

2013
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0751887
Disease: Medullary Neoplasms
Medullary Neoplasms 		0.300 Biomarker CTD_human PD-0332991, a CDK4/6 inhibitor, significantly prolongs survival in a genetically engineered mouse model of brainstem glioma. 24098593

2013
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0751888
Disease: Mesencephalic Neoplasms
Mesencephalic Neoplasms 		0.300 Biomarker CTD_human PD-0332991, a CDK4/6 inhibitor, significantly prolongs survival in a genetically engineered mouse model of brainstem glioma. 24098593

2013
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0751889
Disease: Pontine Tumors
Pontine Tumors 		0.300 Biomarker CTD_human PD-0332991, a CDK4/6 inhibitor, significantly prolongs survival in a genetically engineered mouse model of brainstem glioma. 24098593

2013
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C4721453
Disease: Peripheral Nervous System Diseases
Peripheral Nervous System Diseases 		0.300 Biomarker CTD_human Epigenetic modifications of DAPK and p16 genes contribute to arsenic-induced skin lesions and nondermatological health effects. 23872714

2013
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression 		0.300 Biomarker PSYGENET Up-regulation of leucocytes genes implicated in telomere dysfunction and cellular senescence correlates with depression and anxiety severity scores. 23185405

2012
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0008628
Disease: Chromosome Deletion
Chromosome Deletion 		0.300 Biomarker CTD_human Losses of both products of the Cdkn2a/Arf locus contribute to asbestos-induced mesothelioma development and cooperate to accelerate tumorigenesis. 21526190

2011
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0040715
Disease: Chromosomal translocation
Chromosomal translocation 		0.300 Biomarker CTD_human Characterization of the unique chromosomal translocation identified loss of p16 and upregulation of MDR-1 at protein level. 21325069

2011
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0040715
Disease: Chromosomal translocation
Chromosomal translocation 		0.300 Biomarker CTD_human Losses of both products of the Cdkn2a/Arf locus contribute to asbestos-induced mesothelioma development and cooperate to accelerate tumorigenesis. 21526190

2011
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0041107
Disease: Trisomy
Trisomy 		0.300 Biomarker CTD_human Losses of both products of the Cdkn2a/Arf locus contribute to asbestos-induced mesothelioma development and cooperate to accelerate tumorigenesis. 21526190

2011
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C1297882
Disease: Partial Trisomy
Partial Trisomy 		0.300 Biomarker CTD_human Losses of both products of the Cdkn2a/Arf locus contribute to asbestos-induced mesothelioma development and cooperate to accelerate tumorigenesis. 21526190

2011
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C2930745
Disease: Partial Monosomy
Partial Monosomy 		0.300 Biomarker CTD_human Losses of both products of the Cdkn2a/Arf locus contribute to asbestos-induced mesothelioma development and cooperate to accelerate tumorigenesis. 21526190

2011
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0023453
Disease: L2 Acute Lymphoblastic Leukemia
L2 Acute Lymphoblastic Leukemia 		0.300 Biomarker CTD_human Variation in CDKN2A at 9p21.3 influences childhood acute lymphoblastic leukemia risk. 20453839

2010