|
rs17576
|
|
Renal Cell Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
The present results suggest that MMP9 R279Q polymorphism has influence on the malignant potential of RCC.
|
16466849 |
2006 |
|
rs17576
|
|
Conventional (Clear Cell) Renal Cell Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
The present results suggest that MMP9 R279Q polymorphism has influence on the malignant potential of RCC.
|
16466849 |
2006 |
|
rs17576
|
|
Chlamydia trachomatis infection
|
|
0.010 |
GeneticVariation
|
BEFREE |
The Q279R mutation located in exon 6 of MMP9 was found to be associated with lower risk for severe disease sequelae of ocular Chlamydia trachomatis infection.
|
16643654 |
2006 |
|
rs1430059719
|
|
Fibrosis, Liver
|
|
0.010 |
GeneticVariation
|
BEFREE |
Moreover, adenoviral application of the mutants MMP-9-H401A and -E402Q led to increased apoptosis of activated hepatic stellate cells, thought to be the main promoters of hepatic fibrosis.
|
16507762 |
2006 |
|
rs2250889
|
|
Neoplasm Metastasis
|
|
0.020 |
GeneticVariation
|
BEFREE |
However, after adjustment for age, sex, phenotypic index, moles, and freckles only Q279R, P574R and R668Q had significant associations with intransit metastasis, propensity to tan/sunburn and primary melanoma site.
|
17346338 |
2007 |
|
rs17577
|
|
Neoplasm Metastasis
|
|
0.020 |
GeneticVariation
|
BEFREE |
However, after adjustment for age, sex, phenotypic index, moles, and freckles only Q279R, P574R and R668Q had significant associations with intransit metastasis, propensity to tan/sunburn and primary melanoma site.
|
17346338 |
2007 |
|
rs17577
|
|
melanoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
However, after adjustment for age, sex, phenotypic index, moles, and freckles only Q279R, P574R and R668Q had significant associations with intransit metastasis, propensity to tan/sunburn and primary melanoma site.
|
17346338 |
2007 |
|
rs2664538
|
|
Angle Closure Glaucoma
|
|
0.020 |
GeneticVariation
|
BEFREE |
This study did not find an association between the rs2664538 polymorphism within the MMP-9 gene and PACG in this sample of Chinese subjects.
|
18552608 |
2008 |
|
rs2664538
|
|
Primary angle-closure glaucoma
|
|
0.020 |
GeneticVariation
|
BEFREE |
This study did not find an association between the rs2664538 polymorphism within the MMP-9 gene and PACG in this sample of Chinese subjects.
|
18552608 |
2008 |
|
rs17576
|
|
Prolapsed lumbar disc
|
|
0.020 |
GeneticVariation
|
BEFREE |
Further, a missense SNP in MMP9 (Q279R; rs17576) is also strongly associated with LDH in the Japanese population (p = 0.00049) and shows a combinatorial effect with THBS2 (odds ratio 3.03, 95% confidence interval 1.58-5.77).
|
18455130 |
2008 |
|
rs3918242
|
|
Giant Cell Arteritis
|
|
0.010 |
GeneticVariation
|
BEFREE |
Four SNPs of MMP-9, rs3918242 in the promoter region and 3 nonsynonymous coding SNPs (rs3918252, rs17576, and rs2250889) were genotyped by polymerase chain reaction-restriction fragment length polymorphism analysis in 58 white patients for whom there was a clinical suspicion of GCA.
|
18512818 |
2008 |
|
rs2250889
|
|
Squamous cell carcinoma of esophagus
|
|
0.010 |
GeneticVariation
|
BEFREE |
Our study</span> shows for the first time that MMP-9 gene P574R polymorphism may contribute to a genetic risk factor for ESCC in a Chinese population.
|
18680431 |
2008 |
|
rs2250889
|
|
Giant Cell Arteritis
|
|
0.010 |
GeneticVariation
|
BEFREE |
These data derived from a sample of patients with GCA suggest that the G allele of MMP-9 polymorphism rs2250889 is overrepresented in patients with histologically confirmed GCA.
|
18512818 |
2008 |
|
rs17577
|
|
Squamous cell carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
This study provides evidence for the contribution of the MMP9 Arg668Gln to SCC development.
|
19064570 |
2008 |
|
rs17576
|
|
Squamous cell carcinoma of esophagus
|
|
0.010 |
GeneticVariation
|
BEFREE |
MMP-9 P574R polymorphisms and P574R-R279Q haplotype are significantly associated with the risk of ESCC.
|
18680431 |
2008 |
|
rs17576
|
|
Giant Cell Arteritis
|
|
0.010 |
GeneticVariation
|
BEFREE |
Four SNPs of MMP-9, rs3918242 in the promoter region and 3 nonsynonymous coding SNPs (rs3918252, rs17576, and rs2250889) were genotyped by polymerase chain reaction-restriction fragment length polymorphism analysis in 58 white patients for whom there was a clinical suspicion of GCA.
|
18512818 |
2008 |
|
rs17576
|
|
Coronary Artery Disease
|
|
0.060 |
GeneticVariation
|
BEFREE |
The aim of this study was to analyze the occurrence of the -1612 5A/6A, -376C/G, and Glu45Lys polymorphisms of MMP3 and the -1562C/T and R279Q polymorphisms of MMP9 and their relation to the risk of coronary heart disease (CHD; stenosis >/=50% of the diameter in at least one major coronary artery) in a Chinese Han population.
|
19438845 |
2009 |
|
rs17576
|
|
Angle Closure Glaucoma
|
|
0.050 |
GeneticVariation
|
BEFREE |
In contrast, the SNP rs17576 in MMP-9 might not be related to PACG in the same population.
|
19633731 |
2009 |
|
rs17576
|
|
Primary angle-closure glaucoma
|
|
0.050 |
GeneticVariation
|
BEFREE |
In contrast, the SNP rs17576 in MMP-9 might not be related to PACG in the same population.
|
19633731 |
2009 |
|
rs17576
|
|
Coronary heart disease
|
|
0.030 |
GeneticVariation
|
BEFREE |
The aim of this study was to analyze the occurrence of the -1612 5A/6A, -376C/G, and Glu45Lys polymorphisms of MMP3 and the -1562C/T and R279Q polymorphisms of MMP9 and their relation to the risk of coronary heart disease (CHD; stenosis >/=50% of the diameter in at least one major coronary artery) in a Chinese Han population.
|
19438845 |
2009 |
|
rs2250889
|
|
Primary angle-closure glaucoma
|
|
0.020 |
GeneticVariation
|
BEFREE |
The SNP rs2250889 located in MMP-9 might be associated with PACG among southern Chinese people, and people with the G/G genotype are likely more susceptible to PACG.
|
19633731 |
2009 |
|
rs2250889
|
|
Angle Closure Glaucoma
|
|
0.020 |
GeneticVariation
|
BEFREE |
The SNP rs2250889 located in MMP-9 might be associated with PACG among southern Chinese people, and people with the G/G genotype are likely more susceptible to PACG.
|
19633731 |
2009 |
|
rs17576
|
|
Endometriosis
|
|
0.020 |
GeneticVariation
|
BEFREE |
In the two-locus haplotype analyses using the four single nucleotide polymorphisms (SNPs), an increase in the distribution of the R279Q/P574R (2678G>A/4859C>G) (AC haplotype: odds ratio [OR] = 3.180, 95% confidence interval [CI] = 1.956-5.170; GG haplotype: OR = 4.374, 95% CI = 2.376-8.053) and -1562C>T/R668Q (-1562C>T/5546G>A) (CA haplotype: OR = 3.280, 95% CI = 1.406-7.653) haplotypes was significantly associated with endometriosis.
|
18554596 |
2009 |
|
rs3918242
|
|
Osteoarthritis, Knee
|
|
0.010 |
GeneticVariation
|
BEFREE |
The MMP-1 -1,607 1G/2G (rs1799750), MMP-2 -1,306 C/T (rs243865), and MMP-9 -1,562 C/T (rs3918242) polymorphisms were determined by polymerase chain reaction-restriction fragment length polymorphism assay in 157 patients diagnosed with knee osteoarthritis based on the criteria of American College of Rheumatology and in 84 controls in Mersin, Turkey.
|
18802702 |
2009 |
|
rs2250889
|
|
Endometriosis
|
|
0.010 |
GeneticVariation
|
BEFREE |
In the two-locus haplotype analyses using the four single nucleotide polymorphisms (SNPs), an increase in the distribution of the R279Q/P574R (2678G>A/4859C>G) (AC haplotype: odds ratio [OR] = 3.180, 95% confidence interval [CI] = 1.956-5.170; GG haplotype: OR = 4.374, 95% CI = 2.376-8.053) and -1562C>T/R668Q (-1562C>T/5546G>A) (CA haplotype: OR = 3.280, 95% CI = 1.406-7.653) haplotypes was significantly associated with endometriosis.
|
18554596 |
2009 |