|
rs17576
|
|
Asthma
|
|
0.030 |
GeneticVariation
|
BEFREE |
Published data on the association between <i>MMP-9</i> polymorphisms (-1562 C > T, rs3918242; Gln279Arg, rs17576 Arg668Gln, rs17577) and asthma susceptibility are inconclusive.
|
30931075 |
2019 |
|
rs17576
|
|
Asthma
|
|
0.030 |
GeneticVariation
|
BEFREE |
MMP-9 -1562C>T and 836G>A (Arg279Gln) were not associated with asthma (p> or =0.15) or asthma severity (p> or =0.13), and TIMP-1 434T>C (Phe124Phe) was not associated with asthma in women (p = 0.094) or men (p = 0.207).
|
16061701 |
2005 |
|
rs17576
|
|
Asthma
|
|
0.030 |
GeneticVariation
|
BEFREE |
We were interested in whether the polymorphisms -T1702A, -C1562T, R279Q and +C6T within the matrix metalloproteinase 9 (MMP-9) gene were associated with asthma in a population of 231 asthmatic children.However, we found no association.
|
16026590 |
2005 |
|
rs17576
|
|
Coronary heart disease
|
|
0.030 |
GeneticVariation
|
BEFREE |
This meta-analysis provided evidence that genetic polymorphism of MMP1-1607 1G/2G, MMP3-Gly45lys, MMP3-376 G/C, MMP3-1171 5A/6A, MMP9-1562 C/T and MMP9-R279Q have a small to medium effect on incidence of coronary disease.
|
22226810 |
2012 |
|
rs17576
|
|
Coronary heart disease
|
|
0.030 |
GeneticVariation
|
BEFREE |
The aim of this study was to analyze the occurrence of the -1612 5A/6A, -376C/G, and Glu45Lys polymorphisms of MMP3 and the -1562C/T and R279Q polymorphisms of MMP9 and their relation to the risk of coronary heart disease (CHD; stenosis >/=50% of the diameter in at least one major coronary artery) in a Chinese Han population.
|
19438845 |
2009 |
|
rs17576
|
|
Neoplasm Metastasis
|
|
0.020 |
GeneticVariation
|
BEFREE |
Heritable polymorphisms modulate metastatic efficiency in Cancer Single nucleotide polymorphisms (SNPs) in MMP9 (rs17576) and SIPA1 (rs746429, rs931127) have been associated with nodal metastases in multiple cancers.
|
19906411 |
2010 |
|
rs17576
|
|
Glaucoma, Primary Open Angle
|
|
0.020 |
GeneticVariation
|
BEFREE |
Our data suggest that the MMP1 -1607 1G/2G, MMP2 -1306 C/T, MMP2 -1575 G/A, and MMP9 Q279R polymorphisms themselves are unlikely major risk factors among Caucasian patients with either POAG or XFG.
|
20808730 |
2010 |
|
rs17576
|
|
Behcet Syndrome
|
|
0.020 |
GeneticVariation
|
BEFREE |
The aim of the current case-control study was to investigate the association of four single nucleotide polymorphisms (SNPs) in MMP-9 gene: -1562 C/T, 2003 G/A (R668Q), 836 A/G (Q279R) and 1721 C/G (R574P) with BD risk in the Tunisian population.
|
25639450 |
2015 |
|
rs17576
|
|
Intervertebral Disc Degeneration
|
|
0.020 |
GeneticVariation
|
BEFREE |
Furthermore, the G allele of rs17576 was found to correlate with more severe grades of disc degeneration.
|
30289281 |
2018 |
|
rs17576
|
|
Glaucoma
|
|
0.020 |
GeneticVariation
|
BEFREE |
Our meta-analysis demonstrates that MMP-9 rs17576 G > A polymorphism might be a protective factor against the development of glaucoma in Caucasian population.
|
28431514 |
2017 |
|
rs17576
|
|
Endometriosis
|
|
0.020 |
GeneticVariation
|
BEFREE |
In contrast, for MMP-2 15918 T>C (rs243847), MMP-2 -753 C>T (rs2285053), MMP-7 -181 A>G (rs11568818), MMP-9 -1562 C>T (rs3918242) and MMP-9 R279Q (rs17576) polymorphisms, no association was found in overall comparison, but in subgroup analyses based on source of control, stage of endometriosis, or ethnicity.
|
27620811 |
2016 |
|
rs17576
|
|
Glaucoma
|
|
0.020 |
GeneticVariation
|
BEFREE |
The results suggest that rs17576 was not associated with glaucoma risk based on current publications.
|
26872021 |
2016 |
|
rs17576
|
|
Prolapsed lumbar disc
|
|
0.020 |
GeneticVariation
|
BEFREE |
Our results indicated that the A allele of rs17576 reduced the risk of LDH by ∼23% on average.
|
30289281 |
2018 |
|
rs17576
|
|
Endometriosis
|
|
0.020 |
GeneticVariation
|
BEFREE |
In the two-locus haplotype analyses using the four single nucleotide polymorphisms (SNPs), an increase in the distribution of the R279Q/P574R (2678G>A/4859C>G) (AC haplotype: odds ratio [OR] = 3.180, 95% confidence interval [CI] = 1.956-5.170; GG haplotype: OR = 4.374, 95% CI = 2.376-8.053) and -1562C>T/R668Q (-1562C>T/5546G>A) (CA haplotype: OR = 3.280, 95% CI = 1.406-7.653) haplotypes was significantly associated with endometriosis.
|
18554596 |
2009 |
|
rs17576
|
|
Prolapsed lumbar disc
|
|
0.020 |
GeneticVariation
|
BEFREE |
Further, a missense SNP in MMP9 (Q279R; rs17576) is also strongly associated with LDH in the Japanese population (p = 0.00049) and shows a combinatorial effect with THBS2 (odds ratio 3.03, 95% confidence interval 1.58-5.77).
|
18455130 |
2008 |
|
rs17576
|
|
Myocardial Infarction
|
|
0.020 |
GeneticVariation
|
BEFREE |
C1562T and R279Q polymorphisms are associated with the susceptibility to premature MI, but cannot predict long-term cardiac events in these patients.
|
28453874 |
2018 |
|
rs17576
|
|
Intervertebral Disc Degeneration
|
|
0.020 |
GeneticVariation
|
BEFREE |
Two alleles were significantly associated with disc degeneration: IL-6 rs1800797 and MMP-9 rs17576 and one proved to be protective: IL-6 rs1800795.
|
28551829 |
2017 |
|
rs17576
|
|
Primary malignant neoplasm
|
|
0.020 |
GeneticVariation
|
BEFREE |
Heritable polymorphisms modulate metastatic efficiency in Cancer Single nucleotide polymorphisms (SNPs) in MMP9 (rs17576) and SIPA1 (rs746429, rs931127) have been associated with nodal metastases in multiple cancers.
|
19906411 |
2010 |
|
rs17576
|
|
Glaucoma, Primary Open Angle
|
|
0.020 |
GeneticVariation
|
BEFREE |
Our data suggest that the MMP1 rs1799750 (-1607 1G/2G) and MMP9 rs17576 polymorphisms might be of value for further study as potential gender-dependent risk factors for developing POAG and PACG, respectively, in Pakistan.
|
23441116 |
2013 |
|
rs17576
|
|
Keratoconus
|
|
0.020 |
GeneticVariation
|
BEFREE |
<b>Conclusions</b>: This study supports the hypothesis of a functional role for <i>COL4A3</i> (rs55703767, G/T), <i>MMP-9</i> (rs17576, A/G) and <i>TIMP-1</i> (rs6609533, A/G) SNPs in the pathogenesis of keratoconus.
|
31397194 |
2020 |
|
rs17576
|
|
Behcet Syndrome
|
|
0.020 |
GeneticVariation
|
BEFREE |
our study suggests a significant association of the MMP-9 rs17576 A/G polymorphism with increased risk of BD development in Egyptian patients.
|
28388268 |
2017 |
|
rs17576
|
|
Malignant Neoplasms
|
|
0.020 |
GeneticVariation
|
BEFREE |
Heritable polymorphisms modulate metastatic efficiency in Cancer Single nucleotide polymorphisms (SNPs) in MMP9 (rs17576) and SIPA1 (rs746429, rs931127) have been associated with nodal metastases in multiple cancers.
|
19906411 |
2010 |
|
rs17576
|
|
Myocardial Infarction
|
|
0.020 |
GeneticVariation
|
BEFREE |
The -1562C>T or R2</span>79Q polymorphism of MMP-9 gene and smoking have a synergistic effect and are significantly associated with the risk of MI in Chinese Uighur population, respectively.
|
21733941 |
2012 |
|
rs17576
|
|
Neoplasm Metastasis
|
|
0.020 |
GeneticVariation
|
BEFREE |
These findings indicate that the potentially functional polymorphisms, MMP-9 P574R and R279Q, may confer the biomarker in the occurrence and metastasis of primary lung cancer.
|
16061858 |
2005 |
|
rs17576
|
|
Keratoconus
|
|
0.020 |
GeneticVariation
|
BEFREE |
Our findings showed that the rs55703767G/T polymorphism decreased the risk of KC (OR = 0.26, 95% CI = 0.08-0.82, P = 0.022). rs17576A/G, associated with KC and the A allele, was significantly overrepresented in healthy individuals. rs6609533A/G (X-chromosome) increased the risk of KC in females (OR = 2.27, 95% CI = 1.06-4.76, P = 0.036).
|
28197741 |
2017 |