Gene: APOE ×
Source: ALL
Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs429358
rs429358
APOE
C 0.890 GeneticVariation CLINVAR

dbSNP: rs761592007
rs761592007
APOE
0.020 GeneticVariation BEFREE In a family with autopsy-confirmed Alzheimer disease, the authors found a mutation in the presenilin 2 (PS2) gene (PSEN2) that predicts a methionine-to-isoleucine change at PS2 residue 239 (M239I), at which a change to valine was known in another family. 10822446

2000
dbSNP: rs429358
rs429358
APOE
0.890 GeneticVariation BEFREE Here, we evaluate whether synthetic RNA/DNA oligonucleotides (chimeraplasts) can convert a dysfunctional gene, APOE4 (C, A and E, T, Cys112Arg), a risk factor for Alzheimer's disease and other neurological disorders, into wild-type APOE3. 15781970

2005
dbSNP: rs1440976751
rs1440976751
APOE
0.020 GeneticVariation BEFREE Recent studies have reported a genetic association between the 73 G/A polymorphism within exon 1 of the cystatin C gene and Alzheimer's disease (AD) with conflicting results. 16188386

2006
dbSNP: rs752600356
rs752600356
APOE
0.010 GeneticVariation BEFREE To determine whether M129V polymorphism is a risk factor for AD we analyzed a group of early-onset, and late-onset Polish AD patients. 16897605

2006
dbSNP: rs1440976751
rs1440976751
APOE
0.020 GeneticVariation BEFREE The G73A polymorphism of the CST3 genemay be associated with AD development. 18408364

2008
dbSNP: rs533904656
rs533904656
APOE
0.010 GeneticVariation BEFREE Meta-analyses on AD association with BACE1 exon 5, BACE1 intron 5, FE65 intron 13, CYP46 intron 2, alpha(1)-antichymotrypsine Ala17Thr, bleomycin hydrolase I443V, lectin-like oxidized low-density lipoprotein receptor (OLR1) 3'-UTR (+1071) and (+1073), and very-low-density lipoprotein receptor (VLDLR) 5'-UTR (CGG-repeat) polymorphisms. 17854420

2008
dbSNP: rs405509
rs405509
APOE
0.900 GeneticVariation BEFREE This association is biologically plausible as SNP rs405509 was shown to modify protein binding and transcriptional activity of the APOE protein in vitro and is in linkage disequilibrium with key known variants defining the e2, e3, and e4 alleles that modify risk of atherosclerosis, Alzheimer's disease risk, and progression to AIDS. 19808960

2009
dbSNP: rs405509
rs405509
APOE
0.900 GeneticVariation GWASDB Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease. 19734903

2009
dbSNP: rs405509
rs405509
APOE
0.900 GeneticVariation BEFREE The single nucleotide polymorphisms (SNPs) rs449647, rs769446 and rs405509 in the promoter region of the APOE gene have been variously suggested to be epsilon 4-independent risk factors for Alzheimer's disease (AD). 19172988

2009
dbSNP: rs405509
rs405509
APOE
0.900 GeneticVariation GWASDB Genetic variation in PCDH11X is associated with susceptibility to late-onset Alzheimer's disease. 19136949

2009
dbSNP: rs429358
rs429358
APOE
0.890 GeneticVariation BEFREE ApoE single nucleotide polymorphisms (SNPs) Cys112Arg (Epsilon-4), and Arg158Cys (Epsilon-2) have been implicated in cardiovascular and Alzheimer's disease, but their role in colorectal cancer (CRC) has not been extensively studied. 19455140

2009
dbSNP: rs769446
rs769446
APOE
0.740 GeneticVariation BEFREE The single nucleotide polymorphisms (SNPs) rs449647, rs769446 and rs405509 in the promoter region of the APOE gene have been variously suggested to be epsilon 4-independent risk factors for Alzheimer's disease (AD). 19172988

2009
dbSNP: rs449647
rs449647
APOE
0.730 GeneticVariation BEFREE Therefore this study confirms the role of the rs449647 A/A genotype as risk factor for AD in Italy and suggests that promoter genotypes and APOE haplotypes might have a complex function in AD-associated genetic risk factors. 19172988

2009
dbSNP: rs11542041
rs11542041
APOE
0.010 GeneticVariation BEFREE ApoE single nucleotide polymorphisms (SNPs) Cys112Arg (Epsilon-4), and Arg158Cys (Epsilon-2) have been implicated in cardiovascular and Alzheimer's disease, but their role in colorectal cancer (CRC) has not been extensively studied. 19455140

2009
dbSNP: rs405509
rs405509
APOE
0.900 GeneticVariation GWASDB Dementia revealed: novel chromosome 6 locus for late-onset Alzheimer disease provides genetic evidence for folate-pathway abnormalities. 20885792

2010
dbSNP: rs1233347077
rs1233347077
APOE
0.020 GeneticVariation BEFREE Furthermore, there was no evidence of linkage disequilibrium between the VNTR and -174G/C polymorphisms, not supporting a previous reported additive effect of both IL-6 polymorphisms on AD risk. 19897004

2010
dbSNP: rs405509
rs405509
APOE
0.900 GeneticVariation GWASDB Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease. 21460841

2011
dbSNP: rs405509
rs405509
APOE
0.900 GeneticVariation GWASDB Genome-wide association of familial late-onset Alzheimer's disease replicates BIN1 and CLU and nominates CUGBP2 in interaction with APOE. 21379329

2011
dbSNP: rs429358
rs429358
APOE
0.890 GeneticVariation GWASCAT Genome-wide association study of CSF biomarkers Abeta1-42, t-tau, and p-tau181p in the ADNI cohort. 21123754

2011
dbSNP: rs429358
rs429358
APOE
0.890 GeneticVariation BEFREE Apolipoprotein E (APOE) genotype (ε2/ε3/ε4: rs429358 ε4 allele; rs7412 ε2 allele) is strongly associated with both lipid levels and Alzheimer's disease. 21215387

2011
dbSNP: rs7412
rs7412
APOE
0.720 GeneticVariation BEFREE Apolipoprotein E (APOE) genotype (ε2/ε3/ε4: rs429358 ε4 allele; rs7412 ε2 allele) is strongly associated with both lipid levels and Alzheimer's disease. 21215387

2011
dbSNP: rs1233347077
rs1233347077
APOE
0.020 GeneticVariation BEFREE IL-6 (-174 C/G) polymorphism is not a risk factor for late onset AD in a Polish population. 21225514

2011
dbSNP: rs405509
rs405509
APOE
0.900 GeneticVariation GWASDB Genome-wide association study of Alzheimer's disease with psychotic symptoms. 22005930

2012
dbSNP: rs405509
rs405509
APOE
0.900 GeneticVariation GWASDB Genome-wide association study of Alzheimer's disease. 22832961

2012