Gene: APOE ×
Source: ALL
Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs748703149
rs748703149
APOE
0.010 GeneticVariation BEFREE In a whole-exome sequencing study of a family with probable AD-type dementia without pathogenic variants in known autosomal dominant dementia disease genes and negative for the apolipoprotein E (APOE) ε4 allele, we identified an extremely rare TREM2 coding variant, that is, a glycine-to-tryptophan substitution at amino acid position 145 (NM_018965.3:c.433G>T/p.[Gly145Trp]). 31464095

2020
dbSNP: rs440446
rs440446
APOE
0.010 GeneticVariation BEFREE We tested if the ε4 major isoform of the APOE gene and rs405509 and rs440446 promoter and intron-1 polymorphisms predicted risk of any dementia or Alzheimer's disease with diagnoses derived from the Hospital Discharge and Causes of Death Registers in 1453 participants of the Helsinki Birth Cohort Study. 30293724

2019
dbSNP: rs1270059098
rs1270059098
APOE
0.010 GeneticVariation BEFREE In conclusion, our meta-analysis demonstrates that 5HT2A C10T, but not 5HTTLPR (L/S), might increase risk for AD. 29599928

2018
dbSNP: rs759721023
rs759721023
APOE
0.010 GeneticVariation BEFREE This locus harbors a low-frequency coding variant (p.G215S, rs72973581, minor allele frequency = 4.3%) conferring a modest but statistically significant protection against AD (p-value = 0.024, odds ratio = 0.57, 95% confidence interval = 0.41-0.80). 27289440

2016
dbSNP: rs199768005
rs199768005
APOE
0.010 GeneticVariation BEFREE ApoE variant p.V236E is associated with markedly reduced risk of Alzheimer's disease. 24607147

2014
dbSNP: rs981058595
rs981058595
APOE
0.010 GeneticVariation BEFREE There was no difference in the I405V, C629A, and Taq1B polymorphisms between AD and control groups. 24468472

2014
dbSNP: rs1424027593
rs1424027593
APOE
0.010 GeneticVariation BEFREE Association between the ABCG2 C421A polymorphism and Alzheimer's disease. 23827224

2013
dbSNP: rs1167428194
rs1167428194
APOE
0.010 GeneticVariation BEFREE Nonetheless, the AD associated intronic haplotype is linked to the 338A variant of known ECE1b promoter variant, 338C>A (rs213045). 22693153

2012
dbSNP: rs1438607869
rs1438607869
APOE
0.010 GeneticVariation BEFREE These results suggested that PEMT G523A is associated with AD and that the A allele is an APOE ε4-independent risk factor for AD among Han Chinese women. 21881829

2012
dbSNP: rs11542041
rs11542041
APOE
0.010 GeneticVariation BEFREE ApoE single nucleotide polymorphisms (SNPs) Cys112Arg (Epsilon-4), and Arg158Cys (Epsilon-2) have been implicated in cardiovascular and Alzheimer's disease, but their role in colorectal cancer (CRC) has not been extensively studied. 19455140

2009
dbSNP: rs533904656
rs533904656
APOE
0.010 GeneticVariation BEFREE Meta-analyses on AD association with BACE1 exon 5, BACE1 intron 5, FE65 intron 13, CYP46 intron 2, alpha(1)-antichymotrypsine Ala17Thr, bleomycin hydrolase I443V, lectin-like oxidized low-density lipoprotein receptor (OLR1) 3'-UTR (+1071) and (+1073), and very-low-density lipoprotein receptor (VLDLR) 5'-UTR (CGG-repeat) polymorphisms. 17854420

2008
dbSNP: rs752600356
rs752600356
APOE
0.010 GeneticVariation BEFREE To determine whether M129V polymorphism is a risk factor for AD we analyzed a group of early-onset, and late-onset Polish AD patients. 16897605

2006
dbSNP: rs761592007
rs761592007
APOE
0.020 GeneticVariation BEFREE Autosomal dominant Alzheimer's disease with early frontal lobe involvement associated with the Met239Ile mutation of Presenilin 2 gene. 22531416

2012
dbSNP: rs1233347077
rs1233347077
APOE
0.020 GeneticVariation BEFREE IL-6 (-174 C/G) polymorphism is not a risk factor for late onset AD in a Polish population. 21225514

2011
dbSNP: rs1233347077
rs1233347077
APOE
0.020 GeneticVariation BEFREE Furthermore, there was no evidence of linkage disequilibrium between the VNTR and -174G/C polymorphisms, not supporting a previous reported additive effect of both IL-6 polymorphisms on AD risk. 19897004

2010
dbSNP: rs1440976751
rs1440976751
APOE
0.020 GeneticVariation BEFREE The G73A polymorphism of the CST3 genemay be associated with AD development. 18408364

2008
dbSNP: rs1440976751
rs1440976751
APOE
0.020 GeneticVariation BEFREE Recent studies have reported a genetic association between the 73 G/A polymorphism within exon 1 of the cystatin C gene and Alzheimer's disease (AD) with conflicting results. 16188386

2006
dbSNP: rs761592007
rs761592007
APOE
0.020 GeneticVariation BEFREE In a family with autopsy-confirmed Alzheimer disease, the authors found a mutation in the presenilin 2 (PS2) gene (PSEN2) that predicts a methionine-to-isoleucine change at PS2 residue 239 (M239I), at which a change to valine was known in another family. 10822446

2000
dbSNP: rs1081105
rs1081105
APOE
C 0.700 GeneticVariation GWASCAT Genome-wide meta-analysis identifies new loci and functional pathways influencing Alzheimer's disease risk. 30617256

2019
dbSNP: rs769449
rs769449
APOE
0.700 GeneticVariation GWASCAT Genome-wide analysis of genetic predisposition to Alzheimer's disease and related sex disparities. 30636644

2019
dbSNP: rs769450
rs769450
APOE
G 0.700 GeneticVariation GWASCAT Genome-wide analysis of genetic predisposition to Alzheimer's disease and related sex disparities. 30636644

2019
dbSNP: rs769452
rs769452
APOE
C 0.700 GeneticVariation GWASCAT Genome-wide meta-analysis identifies new loci and functional pathways influencing Alzheimer's disease risk. 30617256

2019
dbSNP: rs1081105
rs1081105
APOE
0.700 GeneticVariation GWASCAT GWAS on family history of Alzheimer's disease. 29777097

2018
dbSNP: rs769449
rs769449
APOE
A 0.700 GeneticVariation GWASCAT GWAS of cerebrospinal fluid tau levels identifies risk variants for Alzheimer's disease. 23562540

2013
dbSNP: rs7412
rs7412
APOE
C 0.720 GeneticVariation GWASCAT Genome-wide analysis of genetic predisposition to Alzheimer's disease and related sex disparities. 30636644

2019