Gene: APOE ×
Source: ALL
Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs1081105
rs1081105
APOE
C 0.700 GeneticVariation GWASCAT Genome-wide meta-analysis identifies new loci and functional pathways influencing Alzheimer's disease risk. 30617256

2019
dbSNP: rs1081105
rs1081105
APOE
0.700 GeneticVariation GWASCAT GWAS on family history of Alzheimer's disease. 29777097

2018
dbSNP: rs11542041
rs11542041
APOE
0.010 GeneticVariation BEFREE ApoE single nucleotide polymorphisms (SNPs) Cys112Arg (Epsilon-4), and Arg158Cys (Epsilon-2) have been implicated in cardiovascular and Alzheimer's disease, but their role in colorectal cancer (CRC) has not been extensively studied. 19455140

2009
dbSNP: rs1167428194
rs1167428194
APOE
0.010 GeneticVariation BEFREE Nonetheless, the AD associated intronic haplotype is linked to the 338A variant of known ECE1b promoter variant, 338C>A (rs213045). 22693153

2012
dbSNP: rs1233347077
rs1233347077
APOE
0.020 GeneticVariation BEFREE IL-6 (-174 C/G) polymorphism is not a risk factor for late onset AD in a Polish population. 21225514

2011
dbSNP: rs1233347077
rs1233347077
APOE
0.020 GeneticVariation BEFREE Furthermore, there was no evidence of linkage disequilibrium between the VNTR and -174G/C polymorphisms, not supporting a previous reported additive effect of both IL-6 polymorphisms on AD risk. 19897004

2010
dbSNP: rs1270059098
rs1270059098
APOE
0.010 GeneticVariation BEFREE In conclusion, our meta-analysis demonstrates that 5HT2A C10T, but not 5HTTLPR (L/S), might increase risk for AD. 29599928

2018
dbSNP: rs1424027593
rs1424027593
APOE
0.010 GeneticVariation BEFREE Association between the ABCG2 C421A polymorphism and Alzheimer's disease. 23827224

2013
dbSNP: rs1438607869
rs1438607869
APOE
0.010 GeneticVariation BEFREE These results suggested that PEMT G523A is associated with AD and that the A allele is an APOE ε4-independent risk factor for AD among Han Chinese women. 21881829

2012
dbSNP: rs1440976751
rs1440976751
APOE
0.020 GeneticVariation BEFREE Recent studies have reported a genetic association between the 73 G/A polymorphism within exon 1 of the cystatin C gene and Alzheimer's disease (AD) with conflicting results. 16188386

2006
dbSNP: rs1440976751
rs1440976751
APOE
0.020 GeneticVariation BEFREE The G73A polymorphism of the CST3 genemay be associated with AD development. 18408364

2008
dbSNP: rs199768005
rs199768005
APOE
0.010 GeneticVariation BEFREE ApoE variant p.V236E is associated with markedly reduced risk of Alzheimer's disease. 24607147

2014
dbSNP: rs405509
rs405509
APOE
0.900 GeneticVariation GWASDB Dementia revealed: novel chromosome 6 locus for late-onset Alzheimer disease provides genetic evidence for folate-pathway abnormalities. 20885792

2010
dbSNP: rs405509
rs405509
APOE
0.900 GeneticVariation BEFREE Rs449647 and rs405509 polymorphisms of <i>APOE</i> gene were not associated with an increase of risk of AD. 28900374

2017
dbSNP: rs405509
rs405509
APOE
0.900 GeneticVariation BEFREE Education, sex, and the APOE-rs405509 variant are associated with Alzheimer's disease and cognitive performance. 31100889

2019
dbSNP: rs405509
rs405509
APOE
0.900 GeneticVariation GWASDB Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease. 21460841

2011
dbSNP: rs405509
rs405509
APOE
0.900 GeneticVariation BEFREE This association is biologically plausible as SNP rs405509 was shown to modify protein binding and transcriptional activity of the APOE protein in vitro and is in linkage disequilibrium with key known variants defining the e2, e3, and e4 alleles that modify risk of atherosclerosis, Alzheimer's disease risk, and progression to AIDS. 19808960

2009
dbSNP: rs405509
rs405509
APOE
0.900 GeneticVariation BEFREE In the presented study, we investigated the association between -491 A/T (rs449647), -427C/T, (rs769446) and -219 T/G (rs405509) single nucleotide polymorphisms (SNPs) of APOE gene and AD risk in the Polish population. 29990559

2018
dbSNP: rs405509
rs405509
APOE
0.900 GeneticVariation GWASDB Genome-wide association of familial late-onset Alzheimer's disease replicates BIN1 and CLU and nominates CUGBP2 in interaction with APOE. 21379329

2011
dbSNP: rs405509
rs405509
APOE
T 0.900 GeneticVariation GWASDB Overrepresentation of glutamate signaling in Alzheimer's disease: network-based pathway enrichment using meta-analysis of genome-wide association studies. 24755620

2014
dbSNP: rs405509
rs405509
APOE
0.900 GeneticVariation GWASDB Genome-wide association study of Alzheimer's disease with psychotic symptoms. 22005930

2012
dbSNP: rs405509
rs405509
APOE
0.900 GeneticVariation BEFREE These results demonstrate that the rs405509 T/T allele of APOE causes an age-related cognitive decline in non-demented elderly people, possibly by modulating brain network communication efficiency, which may be beneficial for understanding the neural mechanisms of rs405509-related cognitive aging and AD pathogenesis. 27636845

2017
dbSNP: rs405509
rs405509
APOE
0.900 GeneticVariation GWASDB Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease. 19734903

2009
dbSNP: rs405509
rs405509
APOE
0.900 GeneticVariation BEFREE Evidence demonstrates that the T allele of the single-nucleotide polymorphism rs405509 in the apolipoprotein E (APOE) promoter is a risk factor for Alzheimer's disease. 27259692

2016
dbSNP: rs405509
rs405509
APOE
0.900 GeneticVariation BEFREE The single nucleotide polymorphisms (SNPs) rs449647, rs769446 and rs405509 in the promoter region of the APOE gene have been variously suggested to be epsilon 4-independent risk factors for Alzheimer's disease (AD). 19172988

2009