Gene: APOE ×
Source: ALL
Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs429358
rs429358
APOE
C 0.890 GeneticVariation CLINVAR

dbSNP: rs449647
rs449647
APOE
0.730 GeneticVariation BEFREE A total of 23 publications (19 for rs449647, ten for rs769446 and ten for rs405509) were retrieved that included 5,703 patients with AD and 5,692 controls. 28900374

2017
dbSNP: rs405509
rs405509
APOE
0.900 GeneticVariation BEFREE Among ε4/ε4 individuals, AD risk</span> increased substantially in a dose-dependent manner with the number of <i>APOE</i> promoter SNP rs405509 <i>T</i> alleles in EastAs <i>(TT</i>: OR (odds ratio) = 27.02, <i>p</i> = 8.80 × 10<sup>-94</sup>; <i>GT</i>: OR = 15.87, <i>p</i> = 2.62 × 10<sup>-9</sup>) and EuroAs (<i>TT</i>: OR = 18.13, <i>p</i> = 2.69 × 10<sup>-108</sup>; <i>GT</i>: OR = 12.63, <i>p</i> = 3.44 × 10<sup>-64</sup>), and rs405509-<i>T</i> homozygotes had a younger onset and more severe cortical atrophy than those with <i>G</i>-allele. 31426376

2019
dbSNP: rs429358
rs429358
APOE
C 0.890 GeneticVariation GWASCAT APOE and BCHE as modulators of cerebral amyloid deposition: a florbetapir PET genome-wide association study. 23419831

2014
dbSNP: rs429358
rs429358
APOE
0.890 GeneticVariation BEFREE APOE gene comprises of three alleles determined by two single nucleotide polymorphisms (rs429358 and rs7412) resulting in the protein isoforms, among which ApoE4 is a confirmed risk factor for Alzheimer's Disease. 29776682

2018
dbSNP: rs7412
rs7412
APOE
0.720 GeneticVariation BEFREE APOE gene comprises of three alleles determined by two single nucleotide polymorphisms (rs429358 and rs7412) resulting in the protein isoforms, among which ApoE4 is a confirmed risk factor for Alzheimer's Disease. 29776682

2018
dbSNP: rs429358
rs429358
APOE
0.890 GeneticVariation BEFREE ApoE single nucleotide polymorphisms (SNPs) Cys112Arg (Epsilon-4), and Arg158Cys (Epsilon-2) have been implicated in cardiovascular and Alzheimer's disease, but their role in colorectal cancer (CRC) has not been extensively studied. 19455140

2009
dbSNP: rs11542041
rs11542041
APOE
0.010 GeneticVariation BEFREE ApoE single nucleotide polymorphisms (SNPs) Cys112Arg (Epsilon-4), and Arg158Cys (Epsilon-2) have been implicated in cardiovascular and Alzheimer's disease, but their role in colorectal cancer (CRC) has not been extensively studied. 19455140

2009
dbSNP: rs199768005
rs199768005
APOE
0.010 GeneticVariation BEFREE ApoE variant p.V236E is associated with markedly reduced risk of Alzheimer's disease. 24607147

2014
dbSNP: rs429358
rs429358
APOE
0.890 GeneticVariation BEFREE Apolipoprotein E (APOE) genotype (ε2/ε3/ε4: rs429358 ε4 allele; rs7412 ε2 allele) is strongly associated with both lipid levels and Alzheimer's disease. 21215387

2011
dbSNP: rs7412
rs7412
APOE
0.720 GeneticVariation BEFREE Apolipoprotein E (APOE) genotype (ε2/ε3/ε4: rs429358 ε4 allele; rs7412 ε2 allele) is strongly associated with both lipid levels and Alzheimer's disease. 21215387

2011
dbSNP: rs1424027593
rs1424027593
APOE
0.010 GeneticVariation BEFREE Association between the ABCG2 C421A polymorphism and Alzheimer's disease. 23827224

2013
dbSNP: rs761592007
rs761592007
APOE
0.020 GeneticVariation BEFREE Autosomal dominant Alzheimer's disease with early frontal lobe involvement associated with the Met239Ile mutation of Presenilin 2 gene. 22531416

2012
dbSNP: rs405509
rs405509
APOE
0.900 GeneticVariation GWASDB Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease. 21460841

2011
dbSNP: rs405509
rs405509
APOE
0.900 GeneticVariation GWASDB Dementia revealed: novel chromosome 6 locus for late-onset Alzheimer disease provides genetic evidence for folate-pathway abnormalities. 20885792

2010
dbSNP: rs405509
rs405509
APOE
0.900 GeneticVariation BEFREE Education, sex, and the APOE-rs405509 variant are associated with Alzheimer's disease and cognitive performance. 31100889

2019
dbSNP: rs405509
rs405509
APOE
0.900 GeneticVariation BEFREE Evidence demonstrates that the T allele of the single-nucleotide polymorphism rs405509 as the apolipoprotein E (APOE) promoter is a risk factor for Alzheimer's disease (AD). 26825091

2016
dbSNP: rs405509
rs405509
APOE
0.900 GeneticVariation BEFREE Evidence demonstrates that the T allele of the single-nucleotide polymorphism rs405509 in the apolipoprotein E (APOE) promoter is a risk factor for Alzheimer's disease. 27259692

2016
dbSNP: rs1233347077
rs1233347077
APOE
0.020 GeneticVariation BEFREE Furthermore, there was no evidence of linkage disequilibrium between the VNTR and -174G/C polymorphisms, not supporting a previous reported additive effect of both IL-6 polymorphisms on AD risk. 19897004

2010
dbSNP: rs429358
rs429358
APOE
0.890 GeneticVariation GWASCAT Genetic heterogeneity of Alzheimer's disease in subjects with and without hypertension. 31055733

2019
dbSNP: rs405509
rs405509
APOE
0.900 GeneticVariation GWASDB Genetic variation in PCDH11X is associated with susceptibility to late-onset Alzheimer's disease. 19136949

2009
dbSNP: rs405509
rs405509
APOE
T 0.900 GeneticVariation GWASCAT Genome-wide analysis of genetic predisposition to Alzheimer's disease and related sex disparities. 30636644

2019
dbSNP: rs429358
rs429358
APOE
0.890 GeneticVariation GWASCAT Genome-wide analysis of genetic predisposition to Alzheimer's disease and related sex disparities. 30636644

2019
dbSNP: rs7259620
rs7259620
APOE
G 0.800 GeneticVariation GWASCAT Genome-wide analysis of genetic predisposition to Alzheimer's disease and related sex disparities. 30636644

2019
dbSNP: rs7412
rs7412
APOE
C 0.720 GeneticVariation GWASCAT Genome-wide analysis of genetic predisposition to Alzheimer's disease and related sex disparities. 30636644

2019