|
Glioblastoma Multiforme
|
0.550 |
PosttranslationalModification
|
disease |
BEFREE |
Moreover, the dimeric bicyclic ligand induced cell detachment and inhibited FAK phosphorylation in U-373 MG glioblastoma cells.
|
31556442 |
2019 |
|
Glioblastoma Multiforme
|
0.550 |
AlteredExpression
|
disease |
BEFREE |
In this report, we found that naringin can specifically inhibit the kinase activity of FAK and suppress the FAK<sup>p-Try397</sup>and its downstream pathway in glioblastoma cells.
|
27125297 |
2017 |
|
Glioblastoma Multiforme
|
0.550 |
Biomarker
|
disease |
BEFREE |
Also, knockdown- or pharmacological agent-based attenuation of EGFR, FAK or Graf (ARHGAP26)/small GTPase-mediated pathways markedly mitigated the aggressiveness of glioblastoma cells.
|
26377974 |
2015 |
|
Glioblastoma Multiforme
|
0.550 |
Biomarker
|
disease |
BEFREE |
Thus, microarray gene expression analysis can be effective in establishing genes affected in response to FAK inhibitor alone and in response to combination of Y15 with temozolomide that is important for glioblastoma therapy.
|
23387973 |
2014 |
|
Glioblastoma Multiforme
|
0.550 |
Biomarker
|
disease |
CTD_human |
Geldanamycin inhibits migration of glioma cells in vitro: a potential role for hypoxia-inducible factor (HIF-1alpha) in glioma cell invasion.
|
12811834 |
2003 |
|
Glioblastoma Multiforme
|
0.550 |
GeneticVariation
|
disease |
UNIPROT |
|
|
|
|
Mammary Neoplasms, Experimental
|
0.500 |
Therapeutic
|
phenotype |
CTD_human |
Mammary gland-specific ablation of focal adhesion kinase reduces the incidence of p53-mediated mammary tumour formation.
|
24809783 |
2014 |
|
Mammary Neoplasms, Experimental
|
0.500 |
Biomarker
|
phenotype |
RGD |
Requirement for focal adhesion kinase in the early phase of mammary adenocarcinoma lung metastasis formation.
|
15930288 |
2005 |
|
Atrial Fibrillation
|
0.400 |
Biomarker
|
disease |
CTD_human |
Multi-ethnic genome-wide association study for atrial fibrillation.
|
29892015 |
2018 |
|
Atrial Fibrillation
|
0.400 |
Biomarker
|
disease |
CTD_human |
Biobank-driven genomic discovery yields new insight into atrial fibrillation biology.
|
30061737 |
2018 |
|
Atrial Fibrillation
|
0.400 |
GeneticVariation
|
disease |
GWASCAT |
Biobank-driven genomic discovery yields new insight into atrial fibrillation biology.
|
30061737 |
2018 |
|
Atrial Fibrillation
|
0.400 |
GeneticVariation
|
disease |
GWASCAT |
Multi-ethnic genome-wide association study for atrial fibrillation.
|
29892015 |
2018 |
|
Glioblastoma
|
0.370 |
PosttranslationalModification
|
disease |
BEFREE |
Moreover, the dimeric bicyclic ligand induced cell detachment and inhibited FAK phosphorylation in U-373 MG glioblastoma cells.
|
31556442 |
2019 |
|
Glioblastoma
|
0.370 |
Biomarker
|
disease |
BEFREE |
A recent study showed that a combination of Y15 (a FAK autophosphorylation inhibitor) with temozolomide (TMZ) treatment was effective in glioblastoma (GBM) therapy.
|
31360198 |
2019 |
|
Glioblastoma
|
0.370 |
AlteredExpression
|
disease |
BEFREE |
In this report, we found that naringin can specifically inhibit the kinase activity of FAK and suppress the FAK<sup>p-Try397</sup>and its downstream pathway in glioblastoma cells.
|
27125297 |
2017 |
|
Glioblastoma
|
0.370 |
Biomarker
|
disease |
BEFREE |
Also, knockdown- or pharmacological agent-based attenuation of EGFR, FAK or Graf (ARHGAP26)/small GTPase-mediated pathways markedly mitigated the aggressiveness of glioblastoma cells.
|
26377974 |
2015 |
|
Glioblastoma
|
0.370 |
Biomarker
|
disease |
BEFREE |
Thus, microarray gene expression analysis can be effective in establishing genes affected in response to FAK inhibitor alone and in response to combination of Y15 with temozolomide that is important for glioblastoma therapy.
|
23387973 |
2014 |
|
Glioblastoma
|
0.370 |
AlteredExpression
|
disease |
LHGDN |
p27Kip1 and cyclin D1 are necessary for focal adhesion kinase regulation of cell cycle progression in glioblastoma cells propagated in vitro and in vivo in the scid mouse brain.
|
15557280 |
2005 |
|
Glioblastoma
|
0.370 |
Biomarker
|
disease |
CTD_human |
Geldanamycin inhibits migration of glioma cells in vitro: a potential role for hypoxia-inducible factor (HIF-1alpha) in glioma cell invasion.
|
12811834 |
2003 |
|
Glioblastoma
|
0.370 |
PosttranslationalModification
|
disease |
LHGDN |
Inhibition of migration of human glioblastoma cells by cerivastatin in association with focal adhesion kinase (FAK).
|
12169389 |
2002 |
|
Squamous cell carcinoma
|
0.350 |
Biomarker
|
disease |
BEFREE |
This inhibitor showed a very potent decrease of autophosphorylation of FAK in squamous cell carcinoma.
|
29897729 |
2018 |
|
Squamous cell carcinoma
|
0.350 |
AlteredExpression
|
disease |
BEFREE |
Tivantinib (ARQ-197) exhibits anti-tumor activity with down-regulation of FAK in oral squamous cell carcinoma.
|
25623532 |
2015 |
|
Squamous cell carcinoma
|
0.350 |
Therapeutic
|
disease |
CTD_human |
Focal adhesion kinase knockdown in carcinoma-associated fibroblasts inhibits oral squamous cell carcinoma metastasis via downregulating MCP-1/CCL2 expression.
|
25199511 |
2015 |
|
Squamous cell carcinoma
|
0.350 |
Biomarker
|
disease |
CTD_human |
Focal adhesion kinase knockdown in carcinoma-associated fibroblasts inhibits oral squamous cell carcinoma metastasis via downregulating MCP-1/CCL2 expression.
|
25199511 |
2015 |
|
Squamous cell carcinoma
|
0.350 |
Biomarker
|
disease |
CTD_human |
Critical role of aquaporin 3 on growth of human esophageal and oral squamous cell carcinoma.
|
21401805 |
2011 |