|
Hypertensive disease
|
0.540 |
GeneticVariation
|
group |
BEFREE |
The presence of type 2 diabetes associated with 3.2-fold increased PAI-1 expression (adjusted p=0.033), while the presence of hypertension associated with about 50% reduction of IL-8 and TIMP-1.
|
25496999 |
2015 |
|
Chronic Obstructive Airway Disease
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
PIM3 allele of α(1)AT gene in COPD patients was found to be associated with low levels of α(1)AT (P = 0.001), the effect being more pronounced when PIM3 combined with rs6609533 of TIMP-1 gene (P = 0.0001).
|
21763297 |
2011 |
|
Heart failure
|
0.240 |
GeneticVariation
|
disease |
BEFREE |
Thus, our findings do not support the hypothesis that the 372 T > C (Phe124Phe) polymorphism in the TIMP-1 gene and the -418 G > C polymorphism in the TIMP-2 gene are associated with HF susceptibility and prognosis in Southern Brazilians.
|
29930267 |
2018 |
|
Congestive heart failure
|
0.240 |
GeneticVariation
|
disease |
BEFREE |
Thus, our findings do not support the hypothesis that the 372 T > C (Phe124Phe) polymorphism in the TIMP-1 gene and the -418 G > C polymorphism in the TIMP-2 gene are associated with HF susceptibility and prognosis in Southern Brazilians.
|
29930267 |
2018 |
|
Congestive heart failure
|
0.240 |
GeneticVariation
|
disease |
BEFREE |
The association of total TIMP -1 with risk of congestive heart failure was statistically significant in an age- and sex-adjusted model, but was attenuated upon adjustment for conventional risk factors.
|
30890055 |
2019 |
|
Intracranial Aneurysm
|
0.220 |
GeneticVariation
|
disease |
LHGDN |
A study sample was analyzed that comprised 44 patients with intracranial aneurysms and 44, 41, and 40 controls for the analysis of TIMP-1, -2, and -3, respectively.
|
14605322 |
2003 |
|
Adenocarcinoma
|
0.100 |
GeneticVariation
|
group |
BEFREE |
This study tests whether constitutional genetic variants in matrix metalloproteinases (MMP) and tissue inhibitors of metalloproteinases (TIMP) genes are associated with outcome of GEJ adenocarcinoma.
|
23527119 |
2013 |
|
Rheumatoid Arthritis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Two SNP were associated with RA in the joint analysis of all samples: rs6520278 (TIMP1) was associated with RA in general (p = 0.035) and rs3093457 (IL9R) with anti-CCP-positive RA patients (p = 0.037) and male RA patients (p = 0.010).
|
19723899 |
2009 |
|
Malignant Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
The results showed that the percentages of TT, CT and CC for TIMP-1 rs4898 genotypes were 28.5%, 33.2% and 38.3% in the patient group and 34.5%, 41.2% and 24.3% in the non-cancer control group, respectively (p for trend=1.21×10(-5)).
|
26722039 |
2016 |
|
Malignant neoplasm of stomach
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Clinical impact of MMP and TIMP gene polymorphisms in gastric cancer.
|
20730428 |
2010 |
|
Malignant neoplasm of stomach
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We genotyped ten common functional polymorphisms of MMP/TIMP genes in 4427 individuals aged 35-69 years without a history of GC who were enrolled in the Japan Multi-institutional Collaborative Cohort Study.
|
27053167 |
2017 |
|
Malignant neoplasm of stomach
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Clinical impact of MMP and TIMP gene polymorphisms in gastric cancer.
|
16940985 |
2006 |
|
Neoplasm Metastasis
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
The CPT1A silenced cells showed an up-regulated transcription of pro-apoptotic genes (BAD, CASP9, COL18A1) and down-modulation of invasion and metastasis related-genes (TIMP-1, PDGF-A, SERPINB2).
|
26799588 |
2016 |
|
Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
A broad spectrum of metalloproteinases, controlled by the Timp gene family, influence the tumour microenvironment in human cancers.
|
25150980 |
2014 |
|
Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Affymetrix array analysis of vector control and TIMP-1 MDA-MB-231 xenograft tumors revealed that TIMP-1 altered expression of approximately 600 genes in vivo, including MMP1, MMP13, S100A14, S100P, Rab25 and ID4.
|
18787947 |
2009 |
|
Degenerative polyarthritis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
After genotyping the samples using standard protocols, the association between <i>MMP-3</i> and <i>TIMP-3</i> single nucleotide polymorphisms and risk of OA was assessed by calculating odds ratios (ORs) and 95% confidence intervals (95% CIs) using unconditional logistic regression analysis.
|
29137364 |
2017 |
|
Degenerative polyarthritis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
To profile the expression of all known members of the matrix metalloproteinase (MMP), ADAMTS, and tissue inhibitor of metalloproteinases (TIMP) gene families in normal cartilage and cartilage from patients with osteoarthritis (OA).
|
14730609 |
2004 |
|
Systemic Scleroderma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
A candidate gene for TIMP-1 gene located on the X-chromosome (rs4898) was selected for a control case study to investigate a possible association of this SNP with the susceptibility to systemic sclerosis and its digit ulcer manifestation.
|
22820628 |
2012 |
|
Systemic Scleroderma
|
0.100 |
GeneticVariation
|
disease |
LHGDN |
Analysis of TIMP-1 gene polymorphisms in Italian sclerodermic patients.
|
16960901 |
2006 |
|
Systemic Scleroderma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Thus, the role of TIMP-1 gene in predisposition to SSc remains controversial.
|
16960901 |
2006 |
|
Aortic Aneurysm, Abdominal
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Analyses with one polymorphism per test without interactions showed an association with the two TIMP1 gene polymorphisms (nt+434, P = .0047; rs2070584, P = .015) in male subjects without a family history of AAA.
|
15944607 |
2005 |
|
Aortic Aneurysm, Abdominal
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Case-control studies assessing the association of at least one SNP in a MMP or TIMP gene with AAA were included.
|
23813847 |
2014 |
|
Aortic Aneurysm, Abdominal
|
0.100 |
GeneticVariation
|
disease |
LHGDN |
Analyses with one polymorphism per test without interactions showed an association with the two TIMP1 gene polymorphisms (nt+434, P = .0047; rs2070584, P = .015) in male subjects without a family history of AAA.
|
15944607 |
2005 |
|
Aortic Aneurysm, Abdominal
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Specific deletion of Timp-1 in GFs abolished the beneficial effect of cell therapy in both AAA mouse models.
|
28582477 |
2017 |
|
Aortic Aneurysm, Abdominal
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
TIMP-1 single nucleotide polymorphisms (SNPs) were analyzed in a primary study sample of 50 patients with AAA and 44 controls.
|
17899257 |
2007 |