|
Neoplasm Invasiveness
|
0.310 |
Therapeutic
|
phenotype |
CTD_human |
Suppression of invasion by inducible expression of tissue inhibitor of metalloproteinase-1 (TIMP-1) in B16-F10 melanoma cells.
|
1318976 |
1992 |
|
Progeria
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Levels of metalloproteinase and TIMP-1 mRNA expression in progeria and Cockayne syndromes were similar to those of early-passage cell cultures.
|
1322316 |
1992 |
|
Werner Syndrome
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
In Werner syndrome cultures expression of metalloproteinase and TIMP-1 mRNAs was similar to the level of expression observed in late-passage cell cultures.
|
1322316 |
1992 |
|
Squamous cell carcinoma
|
0.090 |
AlteredExpression
|
disease |
BEFREE |
In this study, in situ hybridization techniques were used to determine the location of interstitial collagenase and tissue inhibitor of metalloproteinase (TIMP) gene expression in samples from 11 squamous cell carcinomas of the head and neck (particularly the oral cavity) and from non-neoplastic mucosa of the same region.
|
1323216 |
1992 |
|
Wiskott-Aldrich Syndrome
|
0.040 |
GeneticVariation
|
disease |
BEFREE |
These linkage data narrow the boundaries within which the WAS locus maps to the chromosomal region bracketed by TIMP and DXS146 and support the loci order Xpter-DXS7-TIMP-(OATL1, WAS, DXS255)-DXS146.
|
1346773 |
1992 |
|
Fibrosis, Liver
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
These data indicate that hepatic lipocytes can regulate matrix degradation in the liver, and suggest that expression of TIMP-1 by activated lipocytes may contribute to the progression of liver fibrosis.
|
1634616 |
1992 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
The relative levels of TIMP-1 expression did not correlate with the degree of fibrosis of the tumors.
|
1645604 |
1991 |
|
Hodgkin Disease
|
0.050 |
AlteredExpression
|
disease |
BEFREE |
In the present study we investigated the relationship between the expression of TIMP-1 and the clinical behavior of 28 non-Hodgkin's lymphomas.
|
1645604 |
1991 |
|
Lymphoma
|
0.040 |
AlteredExpression
|
group |
BEFREE |
In contrast, transcripts hybridizing with metalloproteinase gene probes (interstitial collagenase and 72-Kd type IV collagenase) were expressed at very low levels in malignant lymphomas and their expression was not coordinately regulated with that of TIMP-1.
|
1645604 |
1991 |
|
Stromal Neoplasm
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Our data suggest the importance of tumor-stromal interactions in non-Hodgkin's lymphomas, and moreover, our results indicate a possible relationship between high-level, localized expression of TIMP-1 and the malignant phenotype of high-grade advanced-stage lymphomas.
|
1645604 |
1991 |
|
Aggressive reaction
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
Northern blot analysis showed that levels of TIMP-1 mRNAs correlated directly with clinical aggressiveness: tumors in the high-grade category contained the highest levels of TIMP-1 transcripts approaching those found in maximally growth factor-stimulated fibroblasts in vitro.
|
1645604 |
1991 |
|
Colon Carcinoma
|
0.080 |
Biomarker
|
disease |
BEFREE |
In addition, the immunoassays we have developed may be useful in further studies on the role of TIMP-1 in human colon cancer.
|
1933883 |
1991 |
|
Malignant tumor of colon
|
0.070 |
Biomarker
|
disease |
BEFREE |
In addition, the immunoassays we have developed may be useful in further studies on the role of TIMP-1 in human colon cancer.
|
1933883 |
1991 |
|
Colonic Neoplasms
|
0.020 |
AlteredExpression
|
group |
BEFREE |
Elevated levels of TIMP-1 protein were found in 31 human colon tumors, compared to paired samples of adjacent normal mucosa.
|
1933883 |
1991 |
|
Ocular albinism, type II
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
Positive lod scores were found for marker loci at the proximal part of the short arm of the X chromosome, DXS255 and TIMP (Zmax = 3.93 and 3.18 at theta = 0.0), suggesting an assignment of the locus for AIED to this part of the X chromosome.
|
2071141 |
1991 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Increased erythroid potentiating activity/tissue inhibitor of metalloproteinases and jun/fos transcription factor complex characterize tumor promoter-induced megakaryoblastic differentiation of K562 leukemia cells.
|
2159816 |
1990 |
|
Wiskott-Aldrich Syndrome
|
0.040 |
Biomarker
|
disease |
BEFREE |
The results confirm close linkage of WAS to the DXS14, DXS7, TIMP, and DXZ1 loci and are consistent with previous data suggesting that WAS maps to the proximal Xp and is flanked by the DXS14 and DXS7 loci.
|
2328995 |
1990 |
|
Wiskott-Aldrich Syndrome
|
0.040 |
GeneticVariation
|
disease |
BEFREE |
Linkage has been established between WAS and DXZ1 (zeta (theta) = 7.08 at theta = 0.03) and WAS and the TIMP gene locus (zeta (theta) = 5.09 at theta = 0.0).
|
2571560 |
1989 |
|
NIGHT BLINDNESS, CONGENITAL STATIONARY, TYPE 2A
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
Pairwise linkage analysis maps the gene for CSNB1 at Xp11.3 and suggests that the CSNB1 locus is distal to another Xp11 marker, TIMP, and proximal to the OTC locus.
|
2574143 |
1989 |
|
Keratoconus
|
0.060 |
GeneticVariation
|
disease |
BEFREE |
This data suggests that the elevated levels of gelatinolytic activity in these keratoconus keratocyte cultures is not due to a primary alteration of the TIMP-1 molecule.
|
7507419 |
1993 |
|
Cicatrix, Hypertrophic
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Alteration in cell morphology triggers transforming growth factor-beta 1, collagenase, and tissue inhibitor of metalloproteinases-I expression in normal and hypertrophic scar fibroblasts.
|
7528243 |
1995 |
|
Secondary malignant neoplasm of lung
|
0.060 |
Biomarker
|
disease |
BEFREE |
Over-expression of tissue inhibitor of matrix metalloproteinases (TIMP1 and TIMP2) suppresses extravasation of pulmonary metastasis of a rat bladder carcinoma.
|
7591285 |
1995 |
|
Carcinoma of bladder
|
0.030 |
Biomarker
|
disease |
BEFREE |
Over-expression of tissue inhibitor of matrix metalloproteinases (TIMP1 and TIMP2) suppresses extravasation of pulmonary metastasis of a rat bladder carcinoma.
|
7591285 |
1995 |
|
Malignant Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
The concomitant overexpression of gelatinase A, gelatinase B, and occasional matrilysin genes was associated with the malignancy of gliomas and accompanied by overexpression of the TIMP-1 gene.
|
7616276 |
1995 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
To find the cause of that difference in vivo and in vitro, the transcriptional regulations of MMP and TIMP genes by tumor promoter, growth factors, or cytokines were studied in vitro.
|
7616276 |
1995 |