|
Alzheimer's Disease
|
0.050 |
Biomarker
|
disease |
BEFREE |
<b>Conclusion:</b> VLDLR and TIMP1 had better discriminative abilities between ADs and controls, and might serve as potential blood biomarkers for AD.
|
30671019 |
2018 |
|
Neoplasm Metastasis
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
<i>In vivo</i>, TIMP-1 neutralization or CD90 blockade significantly reduced metastasis.
|
30482778 |
2019 |
|
Keratoconus
|
0.060 |
GeneticVariation
|
disease |
BEFREE |
Keratoconus corneas exhibited a 2.2-fold increase of catalase mRNA level (P < 0.01) and 1.8-fold of enzyme activity (P < 0.03); a 1.5-fold increase of cathepsin V/L2 mRNA (P < 0.03) and abnormal protein distribution; and a 1.8-fold decrease of TIMP-1 mRNA (P < 0.05) and 2.8-fold decrease of protein (P < 0.0001) compared with normal (physiologic) corneas.
|
15728537 |
2005 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.350 |
Biomarker
|
disease |
CTD_human |
Type 2 diabetes is characterised by reduced monocyte TIMP-1 mRNA levels, and a lower plasma MMP-9 to TIMP-1 protein ratio compared to controls, a pattern that would promote coronary plaque instability if reproduced within vascular plaque.
|
16023759 |
2006 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.350 |
AlteredExpression
|
disease |
BEFREE |
Type 2 diabetes is characterised by reduced monocyte TIMP-1 mRNA levels, and a lower plasma MMP-9 to TIMP-1 protein ratio compared to controls, a pattern that would promote coronary plaque instability if reproduced within vascular plaque.
|
16023759 |
2006 |
|
Respiratory Syncytial Virus Infections
|
0.020 |
AlteredExpression
|
group |
BEFREE |
RSV infection can increase the activity of gelatinase while up-regulating its inhibitory factors but increase its protein ratio of MMP-9/TIMP-1 in lung tissues, thereby facilitating fibrosis after structural destruction of the airway.
|
17254480 |
2007 |
|
Helicobacter Infections
|
0.010 |
AlteredExpression
|
group |
BEFREE |
Helicobacter infection is associated with upregulation of specific TIMPs (TIMP-1 and -3) in glandular epithelium and stroma.
|
17412866 |
2008 |
|
Hereditary gingival fibromatosis
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
HGF fibroblasts cocultured with HGF keratinocytes showed an increased expression of type I collagen and TIMP-1.
|
18589399 |
2008 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Tumor tissue inhibitor of metalloproteinases-1 (TIMP-1) in hormone-independent breast cancer might originate in stromal cells, and improves stratification of prognosis together with nodal status.
|
22465225 |
2012 |
|
Malignant Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Cancer metastasis occurs as a result of imbalance between MMPs and TIMPs.
|
28215146 |
2017 |
|
Primary malignant neoplasm
|
0.100 |
Biomarker
|
group |
BEFREE |
Cancer metastasis occurs as a result of imbalance between MMPs and TIMPs.
|
28215146 |
2017 |
|
Periodontal inflammation
|
0.010 |
Biomarker
|
disease |
BEFREE |
Periodontal inflammation appears associated to MMP-8 and TIMP-1 in blood.
|
28919284 |
2019 |
|
Obesity
|
0.020 |
Biomarker
|
disease |
BEFREE |
Obesity and diabetes are characterized by low grade chronic inflammation status and insulin resistance in adipose tissue associated with metalloproteinase inhibitor 1 (TIMP1).
|
29658577 |
2018 |
|
Anemia
|
0.010 |
Biomarker
|
disease |
BEFREE |
Anemia decreased TIMP-1 in rats fed fermented goat milk with Fe overload, whereas there was increased CTGF and MCP-1 in animals fed fermented cow milk with either normal or Fe overload.
|
30014470 |
2019 |
|
Liver carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
HCC with capsular infiltration also tended to have a higher ratio of MMP-9 mRNA expression to TIMP-1 mRNA expression.
|
8690399 |
1996 |
|
Carcinoma
|
0.080 |
AlteredExpression
|
group |
BEFREE |
TIMP-1 and -2 transcript levels were increased in invasive carcinomas correlating with the histological grade.
|
10628798 |
1999 |
|
Tumor Cell Invasion
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
TIMP-1 is thus considered to inhibit carcinoma invasion and metastasis.
|
10854560 |
2000 |
|
Neoplasm Metastasis
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
TIMP-1 is thus considered to inhibit carcinoma invasion and metastasis.
|
10854560 |
2000 |
|
Glioma
|
0.040 |
Biomarker
|
disease |
BEFREE |
TIMP-1 transcripts were constitutively present in almost all glioma tissues and cell lines, whereas TIMP-2 mRNA were weak especially in malignant gliomas.
|
10895974 |
2000 |
|
Tumor Cell Invasion
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
TIMP-1 is thus considered to inhibit carcinoma invasion and metastasis.
|
11058873 |
2000 |
|
Neoplasm Metastasis
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
TIMP-1 is thus considered to inhibit carcinoma invasion and metastasis.
|
11058873 |
2000 |
|
Chronic Obstructive Airway Disease
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
TIMP-1 levels were also increased after stimulation by PMA and fMLP only in healthy subjects and COPD patients.MMP-8 levels were barely detectable.
|
11167375 |
2001 |
|
Leukemogenesis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Tissue inhibitor of metalloproteinases 1 regulation of interleukin-10 in B-cell differentiation and lymphomagenesis.
|
11238122 |
2001 |
|
Lymphoma, Non-Hodgkin
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
TIMP-1 expression in B-cell NHL correlates closely with IL-10 expression and with high histologic grade.
|
11238122 |
2001 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
TIMP-1 and TIMP-2 inhibited T-cell cytotoxicity against autologous cells presenting tumor-associated antigens and in allogeneic mixed lymphocyte cultures.
|
11756180 |
2002 |